Amidines

beta-secretase 1 ; Homo sapiens







10 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
1 34920170 Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study. 2022 Jan 15 1
2 30709653 New evolutions in the BACE1 inhibitor field from 2014 to 2018. 2019 Mar 15 1
3 31413800 Evaluation of a Series of β-Secretase 1 Inhibitors Containing Novel Heteroaryl-Fused-Piperazine Amidine Warheads. 2019 Aug 8 1
4 29809004 Optimization of 1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors Toward a Clinical Candidate. 2018 Jun 28 1
5 28710924 Identification of new BACE1 inhibitors using Pharmacophore and Molecular dynamics simulations approach. 2017 Sep 2
6 26140617 A Versatile Approach to CF3 -Containing 2-Pyrrolidones by Tandem Michael Addition-Cyclization: Exemplification in the Synthesis of Amidine Class BACE1 Inhibitors. 2015 Aug 10 1
7 24704031 The evolution of amidine-based brain penetrant BACE1 inhibitors. 2014 May 1 2
8 23683349 Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story. 2013 Jun 2
9 22998419 Conformational restriction approach to β-secretase (BACE1) inhibitors: effect of a cyclopropane ring to induce an alternative binding mode. 2012 Oct 25 1
10 20043696 Discovery of cyclic acylguanidines as highly potent and selective beta-site amyloid cleaving enzyme (BACE) inhibitors: Part I--inhibitor design and validation. 2010 Feb 11 1