hydroxyethylene

beta-secretase 1 ; Homo sapiens







10 Article(s)
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Pub. Year
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1 23585822 Design and Synthesis of Hydroxyethylene-Based BACE-1 Inhibitors Incorporating Extended P1 Substituents. 2013 2
2 19995674 P2'-truncated BACE-1 inhibitors with a novel hydroxethylene-like core. 2010 Feb 1
3 20122837 Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) scaffold: exploration of P1' alkoxy residues and an aminoethylene (AE) central core. 2010 Feb 15 4
4 20128595 Design and synthesis of potent and selective BACE-1 inhibitors. 2010 Feb 25 2
5 19169270 Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids. 2009 Feb 2
6 16510290 Design, synthesis, and evaluation of Leu*Ala hydroxyethylene-based non-peptide beta-secretase (BACE) inhibitors. 2006 Jul 1 2
7 14695829 Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase. 2004 Jan 1 5
8 15341936 Modeling the binding affinities of beta-secretase inhibitors: application to subsite specificity. 2004 Oct 4 2
9 12458195 Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism. 2003 Feb 14 2
10 12206667 Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3. 2002 Sep 10 1