Losartan

transforming growth factor, beta 1 ; Rattus norvegicus







61 Article(s)
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1 34622460 Clitoria ternatea (Linn.) flower extract attenuates vascular dysfunction and cardiac hypertrophy via modulation of Ang II/AT1 R/TGF-β1 cascade in hypertensive rats. 2022 Apr 1
2 33606304 Losartan prevents bladder fibrosis and protects renal function in rat with neurogenic paralysis bladder. 2021 Jan 1
3 33771655 trans-Anethole attenuated renal injury and reduced expressions of angiotensin II receptor (AT1R) and TGF-β in streptozotocin-induced diabetic rats. 2021 Jun 2
4 34522623 Angiotensin II type 1 receptor is involved in hypertension and vascular alterations caused by environmental toxicant hexachlorobenzene. 2021 1
5 30021416 Losartan Prevents Maladaptive Auditory-Somatosensory Plasticity After Hearing Loss via Transforming Growth Factor-β Signaling Suppression. 2019 Feb 1
6 30360036 Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment. 2019 Mar 3
7 29436789 Evaluation of Chronic Losartan Treatment Effect on Cardiac Chronotropic Dysfunction in Biliary Cirrhotic Rats. 2018 Jan 3
8 29849726 Renoprotective Effect of a Chinese Herbal Formula, Qidan Dihuang Decoction, on Streptozotocin-Induced Diabetes in Rat. 2018 1
9 30116202 Klotho and PPAR Gamma Activation Mediate the Renoprotective Effect of Losartan in the 5/6 Nephrectomy Model. 2018 1
10 29056916 Inhibition of (pro)renin Receptor Contributes to Renoprotective Effects of Angiotensin II Type 1 Receptor Blockade in Diabetic Nephropathy. 2017 1
11 29404501 Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis. 2017 Nov 1
12 27176484 Losartan Attenuates Myocardial Endothelial-To-Mesenchymal Transition in Spontaneous Hypertensive Rats via Inhibiting TGF-β/Smad Signaling. 2016 4
13 24591528 Inhibition of cellular transdifferentiation by losartan minimizes but does not reverse type 2 diabetes-induced renal fibrosis. 2015 Sep 1
14 25755735 Losartan reduces myocardial interstitial fibrosis in diabetic cardiomyopathy rats by inhibiting JAK/STAT signaling pathway. 2015 2
15 25882007 Beta-casomorphin-7 prevents epithelial-mesenchymal transdifferentiation of NRK-52E cells at high glucose level: Involvement of AngII-TGF-β1 pathway. 2015 Aug 1
16 26175230 Antifibrotic effect of AT-1 blocker and statin in rats with hepatic fibrosis. 2015 Sep 1
17 22483258 Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling. 2013 Aug 20 3
18 22989552 Two drugs with paradoxical effects on liver regeneration through antiangiogenesis and antifibrosis: Losartan and Spironolactone: a pharmacologic dilemma on hepatocyte proliferation. 2013 Jan 2
19 23600142 [Effect of losartan on the protection of the kidney and PRCP-kallikrein axis of the two-kidney, one-clipped renovascular hypertensive rats]. 2013 Jan 2
20 22288068 Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats. 2012 Jan 2
21 22587908 Salt-induced downregulation of renal aquaporins is prevented by losartan. 2012 Aug 20 1
22 23243430 Salvianolic Acid B Attenuates Rat Hepatic Fibrosis via Downregulating Angiotensin II Signaling. 2012 1
23 21868333 [Effect of losartan on renal expression of monocyte chemoattractant protein-1 and transforming growth factor-β(1) in rats after unilateral ureteral obstruction]. 2011 Aug 3
24 20590668 Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells. 2010 Sep 1
25 19597528 Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells. 2009 Aug 1
26 19652382 Effects of angiotensin receptor blocker on oxidative stress and cardio-renal function in streptozotocin-induced diabetic rats. 2009 Aug 1
27 18457832 Comparison of vasculoprotective effects of benidipine and losartan in a rat model of metabolic syndrome. 2008 Jun 10 1
28 18583228 [Perindopril and losartan attenuate bleomycin A5-induced pulmonary fibrosis in rats]. 2008 Jun 2
29 18631342 Do drugs that block transforming growth factor beta reduce posthaemorrhagic ventricular dilatation in a neonatal rat model? 2008 Sep 1
30 18812657 Effect of losartan on cyclooxygenase-2 expression in normal human mesangial cells and kidneys of rats with diabetic nephropathy. 2008 Sep 2
31 18812664 [The effect of losartan on glomerular sclerosis in rats with diabetic nephropathy]. 2008 Sep 2
32 17206447 Angiotensin type 1 (AT1) and type 2 (AT2) receptors mediate the increase in TGF-beta1 in thyroid hormone-induced cardiac hypertrophy. 2007 Apr 1
33 17784886 Angiotension II receptor 1 blocker modifies the expression of apoptosis-related proteins and transforming growth factor-beta1 in prostate tissue of spontaneously hypertensive rats. 2007 Nov 3
34 18182718 [Effect of losartan on the expressions of TGF-beta1, p-Smad2/3, and Smad7 in the remnant renal tissues of 5/6 nephrectomized rats]. 2007 Dec 6
35 16310163 Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. 2006 Jan 13 1
36 16330873 Losartan attenuates bleomycin-induced pulmonary fibrosis in rats. 2006 2
37 15637465 Blockade of angiotensin II with losartan attenuates transforming growth factor-beta1 inducible gene-h3 (betaig-h3) expression in a model of chronic cyclosporine nephrotoxicity. 2005 1
38 16191423 Protective effects of blocking renin-angiotensin system on the progression of renal injury in glomerulosclerosis. 2005 Apr 1
39 16309579 Angiotensin II type I antagonist on oxidative stress and heat shock protein 70 (HSP 70) expression in obstructive nephropathy. 2005 Nov 8 1
40 15149322 Losartan modulation on NOS isoforms and COX-2 expression in early renal fibrogenesis in unilateral obstruction. 2004 Jun 1
41 15573910 Effect of losartan, an angiotensin II antagonist, on hepatic fibrosis induced by CCl4 in rats. 2004 Oct 2
42 12592643 Effect of enalapril and losartan on the events that precede diabetic nephropathy in rats. 2003 Jan-Feb 3
43 12846751 Effects of the combination of an angiotensin II antagonist with an HMG-CoA reductase inhibitor in experimental diabetes. 2003 Aug 1
44 12895325 [Losartan downregulates the expression of transforming growth factor beta type I and type II receptors in kidney of diabetic rat]. 2003 Jun 2
45 12930639 [Effect of ACE-I and AT-1 receptor blocker on the progression of CCl(4)-inducing rat hepatic fibrogenesis]. 2003 Jul 25 1
46 14599716 Expression and localization of AT1 receptors in hepatic Kupffer cells: its potential role in regulating a fibrogenic response. 2003 Nov 15 1
47 11518857 Blood pressure-independent effect of angiotensin AT1 receptor blockade on renal endothelin-1 production in hypertensive uremic rats. 2001 Aug 1
48 11025760 Interaction of nitric oxide and transforming growth factor-beta1 induced by angiotensin II and mechanical stretch in rat renal tubular epithelial cells. 2000 Nov 1
49 11087260 Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. 2000 Dec 1
50 10505424 Ventricular remodeling and transforming growth factor-beta 1 mRNA expression after nontransmural myocardial infarction in rats: effects of angiotensin converting enzyme inhibition and angiotensin II type 1 receptor blockade. 1999 Aug 1