Imatinib Mesylate

ATP binding cassette subfamily B member 1 ; Homo sapiens







123 Article(s)
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101 17180388 The effect of hydroxyurea on P-glycoprotein/BCRP-mediated transport and CYP3A metabolism of imatinib mesylate. 2007 May 6
102 17429432 Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels. 2007 Jul 1
103 17495881 Imatinib disposition and ABCB1 (MDR1, P-glycoprotein) genotype. 2007 Jul 1
104 16890580 Association of enzyme and transporter genotypes with the pharmacokinetics of imatinib. 2006 Aug 2
105 15805252 The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients. 2005 Apr 1 1
106 15902298 Synergistic activity of imatinib and 17-AAG in imatinib-resistant CML cells overexpressing BCR-ABL--Inhibition of P-glycoprotein function by 17-AAG. 2005 Jul 6
107 15918555 [Anticancer drugs and ABC transporters]. 2005 May 1
108 15963852 RNAi-mediated knockdown of P-glycoprotein using a transposon-based vector system durably restores imatinib sensitivity in imatinib-resistant CML cell lines. 2005 Jul 5
109 15970668 Chronic imatinib mesylate exposure leads to reduced intracellular drug accumulation by induction of the ABCG2 (BCRP) and ABCB1 (MDR1) drug transport pumps. 2005 Jul 8
110 16157201 Quantitative molecular monitoring of BCR-ABL and MDR1 transcripts in patients with chronic myeloid leukemia during Imatinib treatment. 2005 Oct 1 3
111 16620554 [Study on the mechanisms of imatinib-resistance of cancer stem-like cells in K562/Vp16 cell line]. 2005 Nov 2
112 14724652 P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate. 2004 Mar 8
113 15250677 Use and limitations of imatinib mesylate (Glivec), a selective inhibitor of the tyrosine kinase Abl transcript in the treatment of chronic myeloid leukaemia. 2004 1
114 15251980 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. 2004 Nov 1 2
115 15308010 [Establishment of an imatinib resistant cell line K562/G01 and its characterization]. 2004 Jun 1
116 15315971 Active transport of imatinib into and out of cells: implications for drug resistance. 2004 Dec 1 1
117 15611623 Pharmacokinetic resistance to imatinib mesylate: role of the ABC drug pumps ABCG2 (BCRP) and ABCB1 (MDR1) in the oral bioavailability of imatinib. 2004 Dec 2
118 12609962 MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. 2003 Mar 15 2
119 12824882 Reversal of the resistance to STI571 in human chronic myelogenous leukemia K562 cells. 2003 Jun 7
120 12869489 Functional consequence of MDR1 expression on imatinib intracellular concentrations. 2003 Aug 1 1
121 12963124 Anti-proliferative effect of the abl tyrosine kinase inhibitor STI571 on the P-glycoprotein positive K562/ADM cell line. 2003 Sep 10 4
122 12975485 Interaction of imatinib mesilate with human P-glycoprotein. 2003 Nov 10
123 14706143 [The reverse effect on drug-resistance against tyrosine kinase inhibitor STI571 in mdr1 and bcr-abl positive leukemic cells]. 2003 Dec 3