Paclitaxel

ATP binding cassette subfamily B member 1 ; Homo sapiens







527 Article(s)
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51 32275773 P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer. 2020 Sep 5
52 32353410 FNDC5 promotes paclitaxel sensitivity of non-small cell lung cancers via inhibiting MDR1. 2020 Aug 2
53 32401925 Treatment with β-elemene combined with paclitaxel inhibits growth, migration, and invasion and induces apoptosis of ovarian cancer cells by activation of STAT-NF-κB pathway. 2020 1
54 32457290 Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1. 2020 May 26 1
55 32489129 Hyaluronic acid reduction-sensitive polymeric micelles achieving co-delivery of tumor-targeting paclitaxel/apatinib effectively reverse cancer multidrug resistance. 2020 Dec 1
56 32497533 The SMAC mimetic LCL161 is a direct ABCB1/MDR1-ATPase activity modulator and BIRC5/Survivin expression down-regulator in cancer cells. 2020 Aug 15 2
57 32536602 Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome. 2020 Jul 15 2
58 32564116 ABCB1 and ERCC1 gene polymorphisms are associated with nephro- and hepatotoxicity to carboplatin/paclitaxel-based chemotherapy in patients with gynecologic cancers. 2020 Oct 3
59 32569926 Synthesis and biological evaluation of thiophenylbenzofuran derivatives as potential P-glycoprotein inhibitors. 2020 Sep 1 2
60 32643224 Carrier-Free Delivery of Precise Drug-Chemogene Conjugates for Synergistic Treatment of Drug-Resistant Cancer. 2020 Oct 5 2
61 32707710 The Multidrug Resistance-Reversing Activity of a Novel Antimicrobial Peptide. 2020 Jul 19 4
62 32872293 Metformin Derivative HL156A Reverses Multidrug Resistance by Inhibiting HOXC6/ERK1/2 Signaling in Multidrug-Resistant Human Cancer Cells. 2020 Aug 28 1
63 32887626 Dual drug-loaded nano-platform for targeted cancer therapy: toward clinical therapeutic efficacy of multifunctionality. 2020 Sep 4 2
64 32903706 Antimicrobial Peptide Reverses ABCB1-Mediated Chemotherapeutic Drug Resistance. 2020 1
65 32984343 Bruton's Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells. 2020 2
66 33050126 Homotype-Targeted Biogenic Nanoparticles to Kill Multidrug-Resistant Cancer Cells. 2020 Oct 9 2
67 33163405 Sapitinib Reverses Anticancer Drug Resistance in Colon Cancer Cells Overexpressing the ABCB1 Transporter. 2020 1
68 33207738 Combination of Inhibitors of USP7 and PLK1 has a Strong Synergism against Paclitaxel Resistance. 2020 Nov 16 2
69 33280384 Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5-a]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators. 2020 Dec 24 2
70 29956630 Formulation, Pharmacokinetic Evaluation and Cytotoxicity of an Enhanced- penetration Paclitaxel Nanosuspension. 2019 2
71 30230544 Chloride channel-3 mediates multidrug resistance of cancer by upregulating P-glycoprotein expression. 2019 May 1
72 30317630 Androgen receptor transcriptional activity and chromatin modifications on the ABCB1/MDR gene are critical for taxol resistance in ovarian cancer cells. 2019 Jun 6
73 30367323 Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters. 2019 Oct 4
74 30391357 Immuno-oncology agent IPI-549 is a modulator of P-glycoprotein (P-gp, MDR1, ABCB1)-mediated multidrug resistance (MDR) in cancer: In vitro and in vivo. 2019 Feb 1 2
75 30711936 AS602801 Sensitizes Ovarian Cancer Stem Cells to Paclitaxel by Down-regulating MDR1. 2019 Feb 3
76 30765569 Structural insight into substrate and inhibitor discrimination by human P-glycoprotein. 2019 Feb 15 2
77 30790579 Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: Food/herb-drug interactions and structure-activity relationships. 2019 Apr 15 2
78 30894541 Multiple ABCB1 transcriptional fusions in drug resistant high-grade serous ovarian and breast cancer. 2019 Mar 20 1
79 30911326 Combination of shikonin with paclitaxel overcomes multidrug resistance in human ovarian carcinoma cells in a P-gp-independent manner through enhanced ROS generation. 2019 2
80 31103263 Intracellular Doppler Spectroscopy detects altered drug response in SKOV3 tumor spheroids with silenced or inhibited P-glycoprotein. 2019 Jul 5 3
81 31106148 Glesatinib, a c-MET/SMO Dual Inhibitor, Antagonizes P-glycoprotein Mediated Multidrug Resistance in Cancer Cells. 2019 1
82 31123858 Impact of gene polymorphisms on the systemic toxicity to paclitaxel/carboplatin chemotherapy for treatment of gynecologic cancers. 2019 Aug 1
83 31127007 Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1). 2019 Aug 2
84 31156720 Cotargeting Plk1 and androgen receptor enhances the therapeutic sensitivity of paclitaxel-resistant prostate cancer. 2019 1
85 31190887 Mitochondria P-glycoprotein confers paclitaxel resistance on ovarian cancer cells. 2019 2
86 31196356 Nano-Porous Silica Aerogels as Promising Biomaterials for Oral Drug Delivery of Paclitaxel. 2019 Jul 1 4
87 31248184 A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor. 2019 Jun 19 1
88 31336860 Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in Paclitaxel-Resistant Ovarian Cancer Cells. 2019 Jul 12 1
89 31350703 Involvement of the MDR1 gene and glycolipids in anticancer drug-resistance of human ovarian carcinoma-derived cells. 2019 Oct 4
90 31404980 Deciphering Hydrodynamic and Drug-Resistant Behaviors of Metastatic EMT Breast Cancer Cells Moving in a Constricted Microcapillary. 2019 Aug 9 1
91 31467112 Breast Cancer Risk-Associated SNPs in the mTOR Promoter Form De Novo KLF5- and ZEB1-Binding Sites that Influence the Cellular Response to Paclitaxel. 2019 Nov 3
92 31476282 Derivative of 5-cyano-6-phenylpyrimidin antagonizes ABCB1- and ABCG2-mediated multidrug resistance. 2019 Nov 15 1
93 31536779 In vitro cytotoxicity of cabazitaxel in adrenocortical carcinoma cell lines and human adrenocortical carcinoma primary cell cultures. 2019 Dec 1 1
94 31570440 Apatinib Reverses Paclitaxel-resistant Lung Cancer Cells (A549) Through Blocking the Function of ABCB1 Transporter. 2019 Oct 4
95 31571407 ABCB1 polymorphism predicts the toxicity and clinical outcome of lung cancer patients with taxane-based chemotherapy. 2019 Nov 1
96 31801248 Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression. 2019 Nov 30 1
97 31867270 Targeting of the Eukaryotic Translation Initiation Factor 4A Against Breast Cancer Stemness. 2019 1
98 28771725 TLR4 and NFκB signaling is critical for taxol resistance in ovarian carcinoma cells. 2018 Mar 6
99 29208281 Overcoming STC2 mediated drug resistance through drug and gene co-delivery by PHB-PDMAEMA cationic polyester in liver cancer cells. 2018 Feb 1 2
100 29251928 Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein. 2018 Feb 8 2