Paclitaxel

ATP binding cassette subfamily B member 1 ; Homo sapiens







527 Article(s)
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451 11159798 A flow cell assay for evaluation of whole cell drug efflux kinetics: analysis of paclitaxel efflux in CCRF-CEM leukemia cells overexpressing P-glycoprotein. 2001 Feb 1
452 11288109 P-glycoprotein efflux pump expression and activity in Calu-3 cells. 2001 May 2
453 11329060 The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. 2001 May 2
454 11392446 Determinants of paclitaxel uptake, accumulation and retention in solid tumors. 2001 May 1
455 11410497 The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel. 2001 Jun 1
456 11465412 P-glycoprotein inhibition leads to enhanced disruptive effects by anti-microtubule cytostatics at the in vitro blood-brain barrier. 2001 May 2
457 11496948 Mdr1 transfection causes enhanced apoptosis by paclitaxel: an effect independent of drug efflux function of P-glycoprotein. 2001 Jul 5
458 11504769 Effects of orally active taxanes on P-glycoprotein modulation and colon and breast carcinoma drug resistance. 2001 Aug 15 6
459 11504826 Kinetics of P-glycoprotein-mediated efflux of paclitaxel. 2001 Sep 7
460 11552225 Pharmacokinetic profiles of doxorubicin in combination with taxanes. 2001 Aug 2
461 11564553 The relationship between Taxol and (+)-discodermolide: synthetic analogs and modeling studies. 2001 Sep 1
462 11605182 Predicting response to paclitaxel/carboplatin-based therapy in non-small cell lung cancer. 2001 Aug 1
463 11606389 The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein. 2001 Oct 15 2
464 11606393 Cross-resistance to the synthetic retinoid CD437 in a paclitaxel-resistant human ovarian carcinoma cell line is independent of the overexpression of retinoic acid receptor-gamma. 2001 Oct 15 2
465 11668581 Abundant expression of the microtubule-associated protein, ensconsin (E-MAP-115), alters the cellular response to Taxol. 2001 Jul 1
466 11710832 Cross-talk between signalling pathways and the multidrug resistant protein MDR-1. 2001 Oct 19 2
467 11780384 Reversing drug resistance in the ovarian carcinoma cell line SKOV3/mdr1 in vitro by antisense oligodeoxynucleotides. 2001 Sep 4
468 11891611 Technetium-99m tetrofosmin chest imaging related to p-glycoprotein expression for predicting the response with paclitaxel-based chemotherapy for non-small cell lung cancer. 2001 2
469 11925927 Analyses by comparative genomic hybridization of genes relating with cisplatin-resistance in ovarian cancer. 2001 Dec 2
470 10601617 Clofazimine and B4121 sensitize an intrinsically resistant human colon cancer cell line to P-glycoprotein substrates. 2000 Jan-Feb 3
471 10741911 Modulation of cisplatin sensitivity by taxol in cisplatin-sensitive and -resistant human ovarian carcinoma cell lines. 2000 Mar 1
472 10745175 Strength and specificity of different gene promoters in oral cancer cells. 2000 Mar 1
473 10755318 N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. 2000 1
474 10803921 Increase in tumor GADD153 mRNA level following treatment correlates with response to paclitaxel. 2000 1
475 10872505 Detection of recombinant P-glycoprotein in multidrug resistant cultured cells. 2000 Feb 2
476 10912951 Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6. 2000 Jun 2
477 10918072 MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping. 2000 Aug 4 2
478 11036469 Multidrug resistance phenotype and paclitaxel (Taxol) sensitivity in human renal carcinoma cell lines of different histologic types. 2000 5
479 11052631 Multiple factors other than p53 influence colon cancer sensitivity to paclitaxel. 2000 1
480 11104578 Antitumour activity of novel taxanes that act at the same time as cytotoxic agents and P-glycoprotein inhibitors. 2000 Dec 1
481 11106232 Phase I trial of paclitaxel plus megestrol acetate in patients with paclitaxel-refractory ovarian cancer. 2000 Nov 2
482 11205313 PSC 833 induces apoptosis in drug-sensitive human leukemia cell line and modulates resistance to paclitaxel in its multidrug-resistant variant. 2000 Nov-Dec 5
483 11218898 [Study of mdr1 antisense oligodeoxynucleotides on reversal of multidrug resistance in ovarian carcinoma cell line SKOV3]. 2000 Nov 1
484 11809106 [The expression of multiple drug resistance associated genes in ovarian cancer]. 2000 Feb 1
485 11876985 [Exploration of factors increasing transfer efficiency of retroviral mediated multidrug resistance gene (mdr1) into human CD(34)(+) cells]. 2000 May 2
486 9864431 The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. 1999 Jan-Feb 3
487 10100591 The bisindolylmaleimide protein kinase C inhibitor, Ro 32-2241, reverses multidrug resistance in KB tumour cells. 1999 1
488 10193934 Effects of paclitaxel on the growth of normal, polyposis, and cancerous human colonic epithelial cells. 1999 Apr 1 2
489 10430060 Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients. 1999 Jul 5
490 10453729 A phase II/pharmacokinetic trial of high-dose progesterone in combination with paclitaxel. 1999 1
491 10576649 The acridonecarboxamide GF120918 potently reverses P-glycoprotein-mediated resistance in human sarcoma MES-Dx5 cells. 1999 Nov 3
492 10602425 Drug-resistance enables selective killing of resistant leukemia cells: exploiting of drug resistance instead of reversal. 1999 Dec 1
493 11498350 Molecular mechanisms of resistance to taxanes and therapeutic implications. 1999 Dec 1
494 11550305 Characterization of paclitaxel (Taxol) sensitivity in human glioma- and medulloblastoma-derived cell lines. 1999 Apr 1
495 9510502 Reversal of multidrug resistance by novel verapamil analogs in cancer cells. 1998 Feb 2
496 9516927 Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast cancer correlate with in vitro resistance to taxol and doxorubicin. 1998 Feb 6
497 9531522 Taxol transport by human intestinal epithelial Caco-2 cells. 1998 Apr 1
498 9572489 Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol. 1998 Apr 23 3
499 9625436 The bisbenzylisoquinoline alkaloids, tetrandine and fangchinoline, enhance the cytotoxicity of multidrug resistance-related drugs via modulation of P-glycoprotein. 1998 Mar 1
500 9738565 Phase I and pharmacokinetic study of paclitaxel in combination with biricodar, a novel agent that reverses multidrug resistance conferred by overexpression of both MDR1 and MRP. 1998 Sep 1