| 1 |
34895068 | Design of a protein-targeted DNA aptamer using atomistic simulation. | 2021 Dec 11 |
1 |
| 2 |
29634247 | Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin. | 2018 May 8 |
1 |
| 3 |
27435675 | Structural Architecture of Prothrombin in Solution Revealed by Single Molecule Spectroscopy. | 2016 Aug 26 |
1 |
| 4 |
20211924 | Replacement of Phe274 with conserved residue Tyr274 for reactive center loop expulsion in antithrombin. | 2011 Jun |
1 |
| 5 |
20404340 | Engineering thrombin for selective specificity toward protein C and PAR1. | 2010 Jun 18 |
2 |
| 6 |
18585267 | Tryptophan-contained peptide-functional nanomaterials as general spectrofluorometric reagents for enzyme. | 2008 Jun 30 |
3 |
| 7 |
17284929 | Lys, pro and trp are critical core amino acid residues recognized by FUM20, a monoclonal antibody against serine protease pan-fungal allergens. | 2007 |
2 |
| 8 |
16641485 | 3-Nitrotyrosine as a spectroscopic probe for investigating protein protein interactions. | 2006 May |
1 |
| 9 |
17001711 | Mapping the fluorophilicity of a hydrophobic pocket: synthesis and biological evaluation of tricyclic thrombin inhibitors directing fluorinated alkyl groups into the p pocket. | 2006 Nov |
1 |
| 10 |
17074754 | Rapid kinetics of Na+ binding to thrombin. | 2006 Dec 29 |
6 |
| 11 |
15771442 | In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. | 2005 Mar 24 |
3 |
| 12 |
12794066 | Roles of low specificity and cofactor interaction sites on thrombin during factor XIII activation. Competition for cofactor sites on thrombin determines its fate. | 2003 Aug 22 |
1 |
| 13 |
14750503 | A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX. | 2003 Dec |
1 |
| 14 |
11297729 | Intrinsic fluorescence changes and rapid kinetics of proteinase deformation during serpin inhibition. | 2001 Apr 6 |
1 |
| 15 |
10739244 | The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors. | 2000 Jan |
1 |
| 16 |
10739383 | Oxidation of human alpha-thrombin by the myeloperoxidase-H2O2-chloride system: structural and functional effects. | 2000 Feb |
1 |
| 17 |
10831587 | Fluorescence properties and functional roles of tryptophan residues 60d, 96, 148, 207, and 215 of thrombin. | 2000 Sep 22 |
2 |
| 18 |
9790668 | Allosteric effects of a monoclonal antibody against thrombin exosite II. | 1998 Oct 27 |
1 |
| 19 |
9351523 | Molecular analysis of a compound heterozygote for hypoprothrombinemia and dysprothrombinemia (-G 7248/7249 and ARG 340 TRP). | 1997 Sep |
2 |
| 20 |
9361370 | Impact of mutations at the P4 and P5 positions on the reaction of antithrombin with thrombin and elastase. | 1997 Oct 15 |
1 |
| 21 |
7510689 | Thrombin and thrombin receptor agonist peptide induce early events of T cell activation and synergize with TCR cross-linking for CD69 expression and interleukin 2 production. | 1994 Mar 18 |
2 |
| 22 |
7526841 | Thrombin-receptor agonist peptides, in contrast to thrombin itself, are not full agonists for activation and signal transduction in human platelets in the absence of platelet-derived secondary mediators. | 1994 Oct 15 |
4 |
| 23 |
8383967 | The N-terminal thrombin receptor fragment SFLLRN, but not catalytically inactive thrombin-derived agonists, activate U937 human monocytic cells: evidence for receptor hydrolysis in thrombin-dependent signalling. | 1993 Mar 1 |
4 |
| 24 |
1354985 | Prothrombin Salakta: substitution of glutamic acid-466 by alanine reduces the fibrinogen clotting activity and the esterase activity. | 1992 Aug 25 |
2 |
| 25 |
1751488 | Reconstitution of catalytically competent human zeta-thrombin by combination of zeta-thrombin residues A1-36 and B1-148 and an Escherichia coli expressed polypeptide corresponding to zeta-thrombin residues B149-259. | 1991 Dec 17 |
4 |
| 26 |
1939071 | Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors. | 1991 Oct 25 |
1 |
| 27 |
2847349 | Modification of human thrombin: effect on thrombomodulin binding. | 1988 Jun 16 |
2 |
| 28 |
3196339 | A hydrophobic site in human prothrombin present in a calcium-stabilized conformer. | 1988 Nov 30 |
1 |
| 29 |
3567158 | Prothrombin Tokushima, a replacement of arginine-418 by tryptophan that impairs the fibrinogen clotting activity of derived thrombin Tokushima. | 1987 Feb 24 |
2 |
| 30 |
3584126 | Antithrombin conformation and the catalytic role of heparin. I. Does cleavage by thrombin induce structural changes in the heparin-binding region of antithrombin? | 1987 Jun 5 |
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| 31 |
6693405 | The heparin-binding site of antithrombin III. Identification of a critical tryptophan in the amino acid sequence. | 1984 Jan 25 |
2 |
| 32 |
6865262 | [Tryptophan loading test as a function parameter in liver diseases]. | 1983 Mar 15 |
1 |
| 33 |
7126590 | Radiation-induced changes in purified prothrombin and thrombin. | 1982 Aug 23 |
1 |
| 34 |
7306521 | Conformational differences between high clotting human alpha-thrombin and nonclotting gamma-thrombin. | 1981 Nov 10 |
9 |
| 35 |
101250 | Functional consequences of tryptophan modification in human fibrinogen. | 1978 Sep 26 |
1 |
| 36 |
409714 | Structure-function relationships in the interaction of alpha-thrombin with blood platelets. | 1977 Oct 25 |
1 |
| 37 |
5534304 | Tyrosine and tryptophan residues and amino groups in thrombin related to enzymic activities. | 1970 Sep 29 |
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