Leukotrienes

arachidonate 5-lipoxygenase ; Mus musculus







109 Article(s)
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51 21067431 Accelerated fracture healing in mice lacking the 5-lipoxygenase gene. 2010 Dec 1
52 18804760 Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. 2009 Apr 2
53 19573621 Lipid bodies in oxidized LDL-induced foam cells are leukotriene-synthesizing organelles: a MCP-1/CCL2 regulated phenomenon. 2009 Nov 1
54 19776641 Polyunsaturated fatty acids and cardiovascular disease: implications for nutrigenetics. 2009 1
55 20091263 (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. 2009 Nov 2
56 17998412 5-Lipoxygenase gene disruption reduces amyloid-beta pathology in a mouse model of Alzheimer's disease. 2008 Apr 1
57 18004232 Leukotriene B4/leukotriene B4 receptor pathway is involved in hepatic microcirculatory dysfunction elicited by endotoxin. 2008 Jul 4
58 18048478 5-Lipoxygenase-derived lipid mediators are not required for the development of NSAID-induced inflammatory bowel disease in IL-10-/- mice. 2008 Feb 1
59 18059327 Effects of zileuton and montelukast in mouse experimental spinal cord injury. 2008 Feb 1
60 18336255 Mast cells and inflammatory heart disease: potential drug targets. 2008 Mar 1
61 17334599 The role of 5-lipoxygenase and leukotrienes in shock and ischemia-reperfusion injury. 2007 Jan 22 2
62 17347013 Inhibition of leukotriene biosynthesis abrogates the host control of Mycobacterium tuberculosis. 2007 Apr 1
63 17392829 Selective 5-lipoxygenase expression in Langerhans cells and impaired dendritic cell migration in 5-LO-deficient mice reveal leukotriene action in skin. 2007 Jul 3
64 17397875 Cysteinyl-leukotriene 1 receptor antagonist attenuates bleomycin-induced pulmonary fibrosis in mice. 2007 Apr 24 1
65 17586489 Role of 5-lipoxygenase in myocardial ischemia-reperfusion injury in mice. 2007 Sep 24 1
66 16489117 Involvement of GATA-3-dependent Th2 lymphocyte activation in airway hyperresponsiveness. 2006 Jun 1
67 16506957 Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice. 2006 Mar 1
68 16624488 Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. 2006 Jul 1
69 17182931 Is there a role for the macrophage 5-lipoxygenase pathway in aortic aneurysm development in apolipoprotein E-deficient mice? 2006 Nov 1
70 20477620 Lipoxygenase and prostaglandin G/H synthase cascades in cardiovascular disease. 2006 Jul 3
71 15661924 Opposing and hierarchical roles of leukotrienes in local innate immune versus vascular responses in a model of sepsis. 2005 Feb 1 2
72 15821759 5-Lipoxygenase modulates colitis through the regulation of adhesion molecule expression and neutrophil migration. 2005 Jun 1
73 15894604 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. 2005 Aug 1 1
74 16046553 Up-regulation of prostaglandin biosynthesis by leukotriene C4 in elicited mice peritoneal macrophages activated with lipopolysaccharide/interferon-{gamma}. 2005 Oct 1
75 16081317 The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis. 2005 Sep 5 2
76 15223810 Endotoxin-induced uveitis in cyclooxygenase-2-deficient mice. 2004 Jul 1
77 15322539 The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. 2004 Sep 1
78 15328042 Experimental allergic encephalomyelitis is exacerbated in mice deficient for 12/15-lipoxygenase or 5-lipoxygenase. 2004 Sep 17 2
79 15353362 Non-prostaglandin eicosanoids in fever and anapyrexia. 2004 Sep 1 1
80 15361791 Mechanisms of leukocyte recruitment to atherosclerotic lesions: future prospects. 2004 Oct 1
81 12730086 Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog. 2003 Jun 1 1
82 11919084 Cloning and functional analysis of the mouse 5-lipoxygenase promoter. 2002 Apr 2
83 12021253 Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo. 2002 May 1
84 12142344 Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. 2002 Jul 26 1
85 12237493 5-lipoxygenase (5LOX)-deficient mice express reduced anxiety-like behavior. 2002 2
86 11160610 Synthesis of 5-oxo-6,8,11,14-eicosatetraenoic acid and identification of novel omega-oxidized metabolites in the mouse macrophage. 2001 Feb 1
87 11254552 Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. 2001 Apr 1
88 11451994 Modulation of cell-substrate adhesion by arachidonic acid: lipoxygenase regulates cell spreading and ERK1/2-inducible cyclooxygenase regulates cell migration in NIH-3T3 fibroblasts. 2001 Jul 1
89 11518028 Effects of furocoumarins from Cachrys trifida on some macrophage functions. 2001 Aug 1
90 11714834 Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. 2001 Dec 1 1
91 10779800 Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 2000 May 1 1
92 11082424 Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97). 2000 Dec 1
93 10384136 Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. 1999 Jul 1 1
94 10514459 Identification of a bipartite nuclear localization sequence necessary for nuclear import of 5-lipoxygenase. 1999 Oct 15 3
95 10586081 Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. 1999 Dec 15 1
96 9744535 Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents. 1998 Aug 1
97 9091580 Role of the 5-lipoxygenase-activating protein (FLAP) in murine acute inflammatory responses. 1997 Mar 17 1
98 8915769 Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo. 1996 Nov 1
99 8955165 Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. 1996 Dec 15 2
100 7969451 Role of leukotrienes revealed by targeted disruption of the 5-lipoxygenase gene. 1994 Nov 10 1