Arsenic Trioxide

PML nuclear body scaffold ; Homo sapiens







135 Article(s)
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101 15160934 The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia. 2004 Apr 4
102 15461930 Arsenic trioxide liposomes: encapsulation efficiency and in vitro stability. 2004 2
103 12667397 Nuclear matrix associated protein PML: an arsenic trioxide apoptosis therapeutic target protein in HepG2 cells. 2003 Jan 1
104 12795834 [Mechanism of arsenic trioxide-induced apoptosis in hepatic blastoma cells HepG2]. 2003 Mar 4
105 12895391 Monitoring PML-RARalpha in acute promyelocytic leukemia. 2003 Sep 1
106 12915590 Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization. 2003 Oct 1 1
107 14534537 Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis. 2003 Oct 9 5
108 14668793 Arsenic enhances the activation of Stat1 by interferon gamma leading to synergistic expression of IRF-1. 2003 Dec 11 2
109 14706140 [Improved RT-PCR for detection of PML/RARalpha fusion gene in rapid diagnosis of acute promyelocytic leukemia]. 2003 Dec 1
110 11890109 Mechanism of action of all-trans retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia. 2002 Feb 1
111 12429934 Arsenic trioxide arrests cells early in mitosis leading to apoptosis. 2002 May-Jun 1
112 11133770 Combined effect of all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia cells in vitro and in vivo. 2001 Jan 1 2
113 11172537 Treatment of acute promyelocytic leukemia with arsenic compounds: in vitro and in vivo studies. 2001 Jan 3
114 11413191 Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation. 2001 Jun 18 10
115 11704843 Arsenic trioxide, a therapeutic agent for APL. 2001 Oct 29 1
116 11704854 Pathways of retinoic acid- or arsenic trioxide-induced PML/RARalpha catabolism, role of oncogene degradation in disease remission. 2001 Oct 29 1
117 11779431 Effect of all-trans retinoic acid and arsenic trioxide on tissue factor expression in acute promyelocytic leukemia cells. 2001 Jan 1
118 10830735 Arsenic trioxide therapy for relapsed acute promyelocytic leukemia: an useful salvage therapy. 2000 Jul 2
119 10910048 BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity. 2000 Jul 1 2
120 11798775 [Effects of arsenic trioxide on K562 cells stably expressing two promyelocytic leukemia-specific fusion proteins]. 2000 Apr 2
121 10023688 Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. 1999 Jan 28 1
122 10328107 Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. 1999 May 5 2
123 10373566 PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. 1999 Jul 3
124 11721366 [Effects of As2O3 on the BCR/ABL protein tyrosine phosphorylation in K562 cells]. 1999 Dec 1
125 9427741 Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus. 1998 Jan 2 2
126 9450572 Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. 1998 Jan 21 1
127 9596679 Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic-resistant NB4 cells. 1998 Jun 1 4
128 9716575 Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner. 1998 Sep 1 11
129 9834237 Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells. 1998 Dec 1 2
130 9129042 Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. 1997 May 1 4
131 9535176 Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis. 1997 Oct-Dec 2
132 9772451 [Double effects of arsenic trioxide (As2O3) on acute promyelocytic leukemic cell line]. 1997 Jul 4
133 15622748 [Effects of arsenic trioxide on the subcellular localization of PML/PML-RARalpha protein in leukemic cells]. 1997 Jan 6
134 8704214 In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins. 1996 Aug 1 8
135 8986606 The PML and PML/RARalpha domains: from autoimmunity to molecular oncology and from retinoic acid to arsenic. 1996 Dec 15 1