Arsenic Trioxide

PML nuclear body scaffold ; Homo sapiens







135 Article(s)
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1 35622143 PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARα. 2022 May 27 3
2 32854112 A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia. 2021 Mar 18 1
3 34310740 RBCK1-TRIB3 decelerated the progression of acute promyelocytic leukemia. 2021 Oct 1
4 32163072 Therapeutic strategy of arsenic trioxide in the fight against cancers and other diseases. 2020 Mar 1 1
5 32223133 Interplay of Ubiquitin-Like Modifiers Following Arsenic Trioxide Treatment. 2020 May 1 5
6 32240679 Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs. 2020 Jun 15 6
7 32328411 ATO (Arsenic Trioxide) Effects on Promyelocytic Leukemia Nuclear Bodies Reveals Antiviral Intervention Capacity. 2020 Apr 2
8 32435915 Biotransformation of arsenic and toxicological implication of arsenic metabolites. 2020 Aug 2
9 32882258 Arsenic induced epigenetic changes and relevance to treatment of acute promyelocytic leukemia and beyond. 2020 Nov 1 2
10 33091440 Balance between the toxicity and anticancer activity of arsenic trioxide in treatment of acute promyelocytic leukemia. 2020 Dec 15 1
11 30763586 Homoharringtonine potentiates the antileukemic activity of arsenic trioxide against acute myeloid leukemia cells. 2019 Mar 15 2
12 30824184 Identification of a point mutation PMLS214L-RARα that alters PML body organization, dynamics and SUMOylation. 2019 Apr 9 4
13 31214877 Realgar transforming solution-induced differentiation of NB4 cell by the degradation of PML/RARα partially through the ubiquitin-proteasome pathway. 2019 Aug 1
14 31670356 Irreversibility of arsenic trioxide induced PML/RARα fusion protein solubility changes. 2019 Dec 11 3
15 28521962 The functional roles of PML nuclear bodies in genome maintenance. 2018 May 1
16 29387217 Effects of lapatinib on cell proliferation and apoptosis in NB4 cells. 2018 Jan 2
17 29596829 Influence of acute promyelocytic leukemia therapeutic drugs on nuclear pore complex density and integrity. 2018 May 15 2
18 29973452 [Acute promyelocytic leukemia: state-of-the-art management]. 2018 2
19 30026570 Molecular remission as a therapeutic objective in acute promyelocytic leukemia. 2018 Aug 2
20 30259936 Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug. 2018 Nov 14 3
21 30662778 An Unusual Coexistence of Primary Central Nervous System Non-Hodgkin's Lymphoma and Acute Promyelocytic Leukemia. 2018 1
22 30693698 [Involvement of PML proteins in treatment of acute promyelocytic leukemia with arsenic trioxide]. 2018 May 25 13
23 27903803 The Human Cytomegalovirus IE1 Protein Antagonizes PML Nuclear Body-Mediated Intrinsic Immunity via the Inhibition of PML De Novo SUMOylation. 2017 Feb 15 1
24 28028657 PML-RARA mutations confer varying arsenic trioxide resistance. 2017 Apr 1
25 28125064 Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes. 2017 Jan 25 2
26 28129653 RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner. 2017 Feb 14 1
27 28239645 PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes. 2017 Feb 23 3
28 28486108 TRIB3 Promotes APL Progression through Stabilization of the Oncoprotein PML-RARα and Inhibition of p53-Mediated Senescence. 2017 May 8 2
29 28492552 All-trans retinoic acid and arsenic trioxide fail to derepress the monocytic differentiation driver Irf8 in acute promyelocytic leukemia cells. 2017 May 11 4
30 28525371 Arsenic trioxide and angiotensin II have inhibitory effects on HERG protein expression: Evidence for the role of PML SUMOylation. 2017 Jul 11 5
31 28656178 Gene Knockout Shows That PML (TRIM19) Does Not Restrict the Early Stages of HIV-1 Infection in Human Cell Lines. 2017 May-Jun 1
32 28695742 Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. 2017 Sep 1 2
33 28712407 [Detection and clinical significance of PML protein expression of acute promyelocytic leukemia cells]. 2017 Jul 2
34 26537301 Varying responses of PML-RARA with different genetic mutations to arsenic trioxide. 2016 Jan 14 2
35 26728337 Mutations affecting both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia. 2016 Mar 3
36 27030546 PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. 2016 Jul 7
37 27133819 PML-RARα kinetics and impact of FLT3-ITD mutations in newly diagnosed acute promyelocytic leukaemia treated with ATRA and ATO or ATRA and chemotherapy. 2016 Oct 1
38 25759405 A novel clonal t(1;4)(p36.1;q31) translocation in acute promyelocytic leukaemia. 2015 May 1
39 25795919 Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells. 2015 May 28 3
40 26058416 Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer. 2015 Dec 2
41 26060329 SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML. 2015 Jun 9 2
42 26118777 Promyelocytic leukemia protein induces arsenic trioxide resistance through regulation of aldehyde dehydrogenase 3 family member A1 in hepatocellular carcinoma. 2015 Sep 28 9
43 26213848 Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation. 2015 Sep 22 4
44 26294332 Evaluating frequency of PML-RARA mutations and conferring resistance to arsenic trioxide-based therapy in relapsed acute promyelocytic leukemia patients. 2015 Nov 2
45 26517826 Sumoylation of the Tumor Suppressor Promyelocytic Leukemia Protein Regulates Arsenic Trioxide-Induced Collagen Synthesis in Osteoblasts. 2015 2
46 27182481 Molecular Monitoring as a Path to Cure Acute Promyelocytic Leukemia. 2015 2
47 24907012 Understanding the molecular pathogenesis of acute promyelocytic leukemia. 2014 Mar 4
48 25319615 Molecular mechanisms of the antileukemia activities of retinoid and arsenic. 2014 4
49 23208507 The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability. 2013 Oct 24 1
50 23430110 Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human. 2013 Apr 18 2