Tretinoin

PML nuclear body scaffold ; Homo sapiens







275 Article(s)
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101 19451220 The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. 2009 May 15 1
102 19702568 Beneficial and adverse effects of molecularly targeted therapies for acute promyelocytic leukemia in central nervous system. 2009 Nov 2
103 19749800 A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes. 2009 Nov 12 1
104 17986232 Promyelocytic leukemia-nuclear body formation is an early event leading to retinoic acid-induced differentiation of neuroblastoma cells. 2008 Jan 2
105 17991421 Coiled-coil domain of PML is essential for the aberrant dynamics of PML-RARalpha, resulting in sequestration and decreased mobility of SMRT. 2008 Jan 11 1
106 18025157 Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RARalpha. 2008 Feb 1 1
107 18039708 Retinoic acid modulates chromatin to potentiate tumor necrosis factor alpha signaling on the DIF2 promoter. 2008 Feb 1
108 18413804 UBE1L represses PML/RAR{alpha} by targeting the PML domain for ISG15ylation. 2008 Apr 3
109 18445086 MEK inhibition induces caspases activation, differentiation blockade and PML/RARalpha degradation in acute promyelocytic leukaemia. 2008 Jul 2
110 18534676 Nuclear organization of PML bodies in leukaemic and multiple myeloma cells. 2008 Dec 3
111 18636162 G0S2 is an all-trans-retinoic acid target gene. 2008 Aug 2
112 18682553 Retinoic acid-stimulated sequential phosphorylation, PML recruitment, and SUMOylation of nuclear receptor TR2 to suppress Oct4 expression. 2008 Aug 12 1
113 18716620 The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. 2008 Oct 9 1
114 19041605 What is the role of arsenic in newly diagnosed APL? 2008 Dec 2
115 16740359 Retinoic acid attenuates promyelocytic leukemia protein-induced cell death in breast cancer cells by activation of the ubiquitin-proteasome pathway. 2007 Mar 18 8
116 17202112 Lysosomes and trivalent arsenic treatment in acute promyelocytic leukemia. 2007 Jan 3 1
117 17317642 Treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide: a paradigm of synergistic molecular targeting therapy. 2007 Jun 29 1
118 17468032 Acute promyelocytic leukemia: new issues on pathogenesis and treatment response. 2007 2
119 17475621 Aberrant association of promyelocytic leukemia protein-retinoic acid receptor-alpha with coactivators contributes to its ability to regulate gene expression. 2007 Jun 22 1
120 17929112 PML-RARalpha inhibitors (ATRA, tamibaroten, arsenic troxide) for acute promyelocytic leukemia. 2007 Oct 1
121 16331271 Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha. 2006 Mar 23 2
122 16405439 A unique case of acute promyelocytic leukemia showing monocytic differentiation after ATRA (all-trans retinoic acid) therapy. 2006 Feb 1
123 16434964 Pro-proliferative function of the long isoform of PML-RARalpha involved in acute promyelocytic leukemia. 2006 Jun 8 5
124 16437139 Relapse of acute promyelocytic leukemia with PML-RARalpha mutant subclones independent of proximate all-trans retinoic acid selection pressure. 2006 Apr 4
125 16501610 The promyelocytic leukemia protein stimulates SUMO conjugation in yeast. 2006 May 18 1
126 16540467 Cytoplasmic function of mutant promyelocytic leukemia (PML) and PML-retinoic acid receptor-alpha. 2006 May 19 2
127 16636064 The estrogen-responsive B box protein is a novel regulator of the retinoid signal. 2006 Jun 30 1
128 16832676 PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter. 2006 Oct 1
129 16835227 Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation. 2006 Sep 8 4
130 16935935 Retinoic acid induces leukemia cell G1 arrest and transition into differentiation by inhibiting cyclin-dependent kinase-activating kinase binding and phosphorylation of PML/RARalpha. 2006 Oct 4
131 17001604 Proteomic analysis of acute promyelocytic leukemia: PML-RARalpha leads to decreased phosphorylation of OP18 at serine 63. 2006 Nov 1
132 17124055 The biology of acute promyelocytic leukemia and its impact on diagnosis and treatment. 2006 1
133 15529177 Promyelocytic leukemia protein-induced growth suppression and cell death in liver cancer cells. 2005 Jan 4
134 15746941 Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells. 2005 May 2
135 15748426 [Basic and clinical studies of the gene product-targeting therapy based on leukemogenesis--editorial]. 2005 Feb 1
136 15894607 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. 2005 May 24 1
137 16112651 Leukomogenic factors downregulate heparanase expression in acute myeloid leukemia cells. 2005 Oct 7 1
138 16187701 Treatment of acute promyelocytic leukemia: a single institution experience. 2005 May-Jun 4
139 16375665 Nuclear proteins: promising targets for cancer drugs. 2005 Dec 2
140 14630830 Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia. 2004 Mar 15 3
141 14871822 Restoration of promyelocytic leukemia protein-nuclear bodies in neuroblastoma cells enhances retinoic acid responsiveness. 2004 Feb 1 2
142 14976209 Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. 2004 Apr 30 1
143 14976428 A new role for C/EBPbeta in acute promyelocytic leukemia. 2004 Apr 1
144 15103387 Acute promyelocytic leukemia: PML/RARalpha and the leukemic stem cell. 2004 Jul 2
145 15116119 Acute promyelocytic leukemia cell line AP-1060 established as a cytokine-dependent culture from a patient clinically resistant to all-trans retinoic acid and arsenic trioxide. 2004 Jul 2
146 15124139 Update in acute leukemia 2003: a risk adapted approach to acute myeloblastic leukemia in adults. 2004 Apr 1
147 15160908 Clinico-biological features and prognostic significance of PML/RARalpha isoforms in adult patients with acute promyelocytic leukemia treated with all trans retinoic acid (ATRA) and chemotherapy. 2004 Mar 2
148 15160934 The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia. 2004 Apr 4
149 15179005 Pathogenesis, diagnosis and monitoring of residual disease in acute promyelocytic leukaemia. 2004 1
150 15218975 Tetraploid acute promyelocytic leukemia with double PML/RARA gene rearrangements successfully treated with all-trans retinoic acid. 2004 May 1