Tretinoin

PML nuclear body scaffold ; Homo sapiens







275 Article(s)
Download
PMID
Title
Pub. Year
#Total Relationships
51 27888400 Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block in acute promyelocytic leukemia. 2016 Dec 1
52 28959333 Analysis of Promyelocytic Leukemia in Human Embryonic Carcinoma Stem Cells During Retinoic Acid-Induced Neural Differentiation. 2016 Sep 4
53 25514379 Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells. 2015 Jan 20 2
54 25692052 High-Risk Microgranular Acute Promyelocytic Leukemia with a Five-Way Complex Translocation Involving PML-RARA. 2015 1
55 25759405 A novel clonal t(1;4)(p36.1;q31) translocation in acute promyelocytic leukaemia. 2015 May 1
56 25795919 Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells. 2015 May 28 2
57 25800051 Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells. 2015 May 28 1
58 25849135 Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. 2015 May 1
59 25973309 Reactive oxygen species regulate the differentiation of acute promyelocytic leukemia cells through HMGB1-mediated autophagy. 2015 5
60 26058416 Synergistic targeted therapy for acute promyelocytic leukaemia: a model of translational research in human cancer. 2015 Dec 2
61 26637766 Acute myeloid leukemia in children and adolescents: identification of new molecular targets brings promise of new therapies. 2015 2
62 26775483 [Significance of PLSCR1 in Matrine Induced Differentiation of ATRA Resistant APL Cells]. 2015 Nov 2
63 26862315 Central nervous system haemorrhage causing early death in acute promyelocytic leukaemia. 2015 2
64 23770850 Coordinated regulation of the immunoproteasome subunits by PML/RARα and PU.1 in acute promyelocytic leukemia. 2014 May 22 2
65 24566867 Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392. 2014 Apr 15 3
66 24592821 Incorporation of arsenic trioxide in induction therapy improves survival of patients with newly diagnosed acute promyelocytic leukaemia. 2014 Jul 2
67 24596215 PML nuclear bodies mediate the therapeutic response of APL cells. 2014 Mar 3
68 24907012 Understanding the molecular pathogenesis of acute promyelocytic leukemia. 2014 Mar 2
69 25126724 MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia. 2014 Oct 1 1
70 25258343 Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation. 2014 Dec 11 1
71 22964640 miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia. 2013 Aug 1 1
72 23159843 Rapid detection of PML-RARA fusion gene by novel high-speed droplet-reverse transcriptase-polymerase chain reaction: possibility for molecular diagnosis without lagging behind the morphological analyses. 2013 Jan 16 1
73 23627671 The short isoform of the long-type PML-RARA fusion gene in acute promyelocytic leukaemia lacks sensitivity to all-trans-retinoic acid. 2013 Jul 1
74 23670176 Mechanisms of action and resistance to all-trans retinoic acid (ATRA) and arsenic trioxide (As2O 3) in acute promyelocytic leukemia. 2013 Jun 2
75 23998577 Expression of PML-RARα is up-regulated during ATRA and arsenics combined induction without influence on long-term prognosis of acute promyelocytic leukemia. 2013 Aug 2
76 24344243 Synergy against PML-RARa: targeting transcription, proteolysis, differentiation, and self-renewal in acute promyelocytic leukemia. 2013 Dec 16 2
77 22406747 Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. 2012 Mar 11 2
78 22845560 DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling. 2012 Nov 1 1
79 22969967 Interferon-γ enhances promyelocytic leukemia protein expression in acute promyelocytic cells and cooperates with all-trans-retinoic acid to induce maturation of NB4 and NB4-R1 cells. 2012 May 1
80 23049403 Molecular basis for the diagnosis and treatment of acute promyelocytic leukemia. 2012 1
81 23098119 All-trans retinoic acid in the treatment of pediatric acute promyelocytic leukemia. 2012 Sep 2
82 23155234 DNA methylation in ATRA-treated leukemia cell lines lacking a PML-RAR chromosome translocation. 2012 Nov 1
83 23300507 Anti-PML-RARα shRNA sensitises promyelocytic leukaemia cells to all-trans retinoic acid. 2012 2
84 21187718 Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein. 2011 Apr 3
85 21360626 Promyelocytic leukemia protein in retinoic acid-induced chromatin remodeling of Oct4 gene promoter. 2011 Apr 2
86 21422471 From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia. 2011 Jun 16 1
87 21790894 Advances in therapies for acute promyelocytic leukemia. 2011 Nov 2
88 21859732 Clinical impact of FLT3 mutation load in acute promyelocytic leukemia with t(15;17)/PML-RARA. 2011 Dec 1
89 22040992 [PML-RARα and p21 are key factors for maintaining acute promyelocytic leukemia stem cells survival]. 2011 Oct 2
90 22586354 The drug-induced degradation of oncoproteins: an unexpected Achilles' heel of cancer cells? 2011 Jul 1
91 20084480 Antiproliferative effect of 13-cis-retinoic acid is associated with granulocyte differentiation and decrease in cyclin B1 and Bcl-2 protein levels in G0/G1 arrested HL-60 cells. 2010 Sep 2
92 20224268 Isochromosome der(17)(q10)t(15;17) in acute promyelocytic leukemia resulting in an additional copy of the RARA-PML fusion gene: report of 4 cases and review of the literature. 2010 1
93 20455087 Eradication of acute promyelocytic leukemia-initiating cells by PML/RARA-targeting. 2010 Jun 2
94 20528759 The impact of molecularly targeted therapies upon the understanding of leukemogenesis and the role of hematopoietic stem cell transplantation in acute promyelocytic leukemia. 2010 Dec 2
95 20574048 Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein. 2010 Sep 30 2
96 20615082 Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells. 2010 Sep 4
97 20935222 Blockade of the ubiquitin protease UBP43 destabilizes transcription factor PML/RARα and inhibits the growth of acute promyelocytic leukemia. 2010 Dec 1 4
98 19155306 Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha. 2009 Feb 1 1
99 19204783 HDAC3 as a molecular chaperone for shuttling phosphorylated TR2 to PML: a novel deacetylase activity-independent function of HDAC3. 2009 2
100 19273155 PML nuclear bodies in the pathogenesis of acute promyelocytic leukemia: active players or innocent bystanders? 2009 Jan 1 4