Imatinib Mesylate

KIT proto-oncogene, receptor tyrosine kinase ; Homo sapiens







1113 Article(s)
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51 32099073 Novel pathogenic alterations in pediatric and adult desmoid-type fibromatosis - A systematic analysis of 204 cases. 2020 Feb 25 1
52 32116712 Clonal Selection of a Novel Deleterious TP53 Somatic Mutation Discovered in ctDNA of a KIT/PDGFRA Wild-Type Gastrointestinal Stromal Tumor Resistant to Imatinib. 2020 1
53 32198455 Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells. 2020 Mar 20 2
54 32291709 Spectrum of activity of dasatinib against mutant KIT kinases associated with drug-sensitive and drug-resistant gastrointestinal stromal tumors. 2020 Sep 2
55 32350132 Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors. 2020 Apr 29 2
56 32371592 Preclinical Activity of PI3K Inhibitor Copanlisib in Gastrointestinal Stromal Tumor. 2020 Jun 3
57 32457834 Talimogene Laherparepvec in Advanced Mucosal Melanoma of the Urethra Upon Primary Resistance on Immune Checkpoint Inhibition: A Case Report. 2020 1
58 32560620 Encapsulation of Imatinib in Targeted KIT-5 Nanoparticles for Reducing its Cardiotoxicity and Hepatotoxicity. 2020 1
59 32615108 Avapritinib in advanced PDGFRA D842V-mutant gastrointestinal stromal tumour (NAVIGATOR): a multicentre, open-label, phase 1 trial. 2020 Jul 1
60 32619820 Prognostic Indicators for Gastrointestinal Stromal Tumors: A Review. 2020 Oct 1
61 32640452 An Unexpected Response to Imatinib in a "Wild-Type" Gastrointestinal Stromal Tumor. 2020 1
62 32697050 Exon 11 homozygous mutations and intron 10/exon 11 junction deletions in the KIT gene are associated with poor prognosis of patients with gastrointestinal stromal tumors. 2020 Sep 3
63 32753885 Chloroquine Combined with Imatinib Overcomes Imatinib Resistance in Gastrointestinal Stromal Tumors by Inhibiting Autophagy via the MAPK/ERK Pathway. 2020 1
64 32836055 BRAF mutations in KIT/PDGFRA positive gastrointestinal stromal tumours (GISTs): Is their frequency underestimated? 2020 Nov 1
65 32843387 Chronic mast cell leukaemia with exon 9 KIT mutation A502_Y503dup: a rare imatinib responsive variant. 2020 Aug 24 1
66 32999756 Expression differences of miR-142-5p between treatment-naïve chronic myeloid leukemia patients responding and non-responding to imatinib therapy suggest a link to oncogenic ABL2, SRI, cKIT and MCL1 signaling pathways critical for development of therapy resistance. 2020 1
67 33024275 The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor. 2020 Dec 2
68 33116851 Abnormal MGMT Promoter Methylation in Gastrointestinal Stromal Tumors: Genetic Susceptibility and Association with Clinical Outcome. 2020 1
69 33195674 Gastrointestinal stromal tumor metastasis at the site of a totally implantable venous access port insertion: A rare case report. 2020 Oct 26 1
70 33212994 A Novel Kindred with Familial Gastrointestinal Stromal Tumors Caused by a Rare KIT Germline Mutation (N655K): Clinico-Pathological Presentation and TKI Sensitivity. 2020 Nov 17 2
71 33468755 [A Case of a Huge Gastrointestinal Stromal Tumor with Extraluminal Growth Arising in the Small Intestine Diagnosed as an Ovarian Tumor]. 2020 Dec 1
72 28777148 New Mechanisms of mTOR Pathway Activation in KIT-mutant Malignant GISTs. 2019 Jan 1
73 30075827 Efficacy Evaluation of Imatinib for the Treatment of Melanoma: Evidence From a Retrospective Study. 2019 Mar 29 2
74 30079802 Hepatitis B virus reactivation following imatinib therapy: A comparative review of 9 cases. 2019 Sep 1
75 30126859 Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib. 2019 May 1
76 30199578 Successful treatment of metastatic mucosal melanoma with a Del579 c-KIT mutation by imatinib after treatment of anti-PD-1 antibody. 2019 Mar 1
77 30523507 PLX9486 shows anti-tumor efficacy in patient-derived, tyrosine kinase inhibitor-resistant KIT-mutant xenograft models of gastrointestinal stromal tumors. 2019 May 1
78 30530703 Anagrelide for Gastrointestinal Stromal Tumor. 2019 Mar 1 1
79 30536695 Systemic mastocytosis in adults: 2019 update on diagnosis, risk stratification and management. 2019 Mar 1
80 30569109 Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress. 2019 Mar 1
81 30612056 Molecular response to imatinib in KIT F522C-mutated systemic mastocytosis. 2019 Feb 1
82 30614559 Response to imatinib in vaginal melanoma with KIT p.Val559Gly mutation previously treated with nivolumab, pembrolizumab and ipilimumab. 2019 Jun 1
83 30684595 Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models. 2019 Apr 10 3
84 30697609 Neoadjuvant and adjuvant therapy for gastrointestinal stromal tumors. 2019 Jan 2
85 30707374 KIT as an Oncogenic Driver in Melanoma: An Update on Clinical Development. 2019 Jun 1
86 30792533 Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours. 2019 Mar 4
87 30864679 [Corrigendum] Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression. 2019 May 1
88 30880826 Female Adnexal Tumour of Probable Wolffian Origin (FATWO): Review of the Literature. 2019 Mar 1
89 30902661 Expanding spectrum of anticancer drug, imatinib, in the disorders affecting brain and spinal cord. 2019 May 1
90 30984366 Survival in advanced GIST has improved over time and correlates with increased access to post-imatinib tyrosine kinase inhibitors: results from Life Raft Group Registry. 2019 1
91 31037149 Repurposing Ponatinib as a Potent Agent against KIT Mutant Melanomas. 2019 3
92 31043947 Lack of Response to Imatinib in Melanoma Carrying Rare KIT Mutation p.T632I. 2019 Jan-Apr 3
93 31046271 Discovery of ( E)- N1-(3-Fluorophenyl)- N3-(3-(2-(pyridin-2-yl)vinyl)-1 H-indazol-6-yl)malonamide (CHMFL-KIT-033) as a Novel c-KIT T670I Mutant Selective Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs). 2019 May 23 1
94 31083182 Relationship between efficacy of sunitinib and KIT mutation of patients with advanced gastrointestinal stromal tumors after failure of imatinib: A systematic review. 2019 May 1
95 31138788 A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer. 2019 May 28 1
96 31205499 New frontiers in the medical management of gastrointestinal stromal tumours. 2019 1
97 31205508 Axitinib overcomes multiple imatinib resistant cKIT mutations including the gatekeeper mutation T670I in gastrointestinal stromal tumors. 2019 2
98 31236647 Basic Knowledge in Soft Tissue Sarcoma. 2019 Sep 1
99 31308690 Targeted therapy and personalized medicine in gastrointestinal stromal tumors: drug resistance, mechanisms, and treatment strategies. 2019 2
100 31363162 Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors. 2019 Sep 6