Tyrphostins

epidermal growth factor receptor ; Homo sapiens







92 Article(s)
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1 31139331 Constitutive activation of EGFR is associated with tumor progression and plays a prominent role in malignant phenotype of chondrosarcoma. 2019 May 7 3
2 31613219 Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. 2019 Oct 15 1
3 29447132 Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II). 2018 May 1
4 27266882 Luteolin Impacts on the DNA Damage Pathway in Oral Squamous Cell Carcinoma. 2016 Jul 1
5 27480860 Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. 2016 Oct 2
6 27806094 EGF-Induced VEGF Exerts a PI3K-Dependent Positive Feedback on ERK and AKT through VEGFR2 in Hematological In Vitro Models. 2016 2
7 23010081 Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR. 2013 Jan 1 1
8 23496660 EGFR tyrosine kinase regulates human small-conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK-293 cells. 2013 May 15 1
9 21952748 EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells. 2012 Feb 1
10 22763976 The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. 2012 Jul 5 2
11 21087080 Calcium-induced apoptosis is delayed by HER1 receptor signalling through the Akt and PLCγ pathways in bladder cancer cells. 2011 Feb 1
12 21171079 The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target. 2011 Feb 2
13 21659924 ErbB expression, activation, and inhibition with lapatinib and tyrphostin (AG825) in human vestibular schwannomas. 2011 Jul 1
14 21697238 Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation. 2011 Oct 1
15 21864510 The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms. 2011 Dec 1 1
16 21887406 Growth factor/growth factor receptor loops in autocrine growth regulation of human prostate cancer DU145 cells. 2011 1
17 20008468 Dihydrotestosterone activates the MAPK pathway and modulates maximum isometric force through the EGF receptor in isolated intact mouse skeletal muscle fibres. 2010 Feb 1 1
18 20149940 (Arene)Ru(II) complexes of epidermal growth factor receptor inhibiting tyrphostins with enhanced selectivity and cytotoxicity in cancer cells. 2010 May 3
19 20202741 Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. 2010 Aug 28 1
20 20351270 Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation. 2010 Apr 13 1
21 20395290 HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia. 2010 Jul 2
22 20538600 Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity. 2010 Aug 6 3
23 19056766 Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions. 2009 Feb 1
24 19058300 Aberrant expression of proteinase-activated receptor 4 promotes colon cancer cell proliferation through a persistent signaling that involves Src and ErbB-2 kinase. 2009 Apr 1 1
25 19947936 Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells. 2009 Dec 16 2
26 17717322 Secretion of IL-13 by airway epithelial cells enhances epithelial repair via HB-EGF. 2008 Feb 1
27 18695891 Tyrphostin AG1478 suppresses proliferation and invasion of human breast cancer cells. 2008 Sep 2
28 18754049 Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478. 2008 Sep 2
29 18855573 A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490. 2008 Oct 1
30 17295209 Radiation-induced PARP activation is enhanced through EGFR-ERK signaling. 2007 Aug 15 1
31 17440440 A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis. 2007 Jul 1
32 16886596 Concomitant cell growth and differentiation are dependent on erbB1 and integrin activation in an autonomously surviving colon adenocarcinoma: involvement of autocrine amphiregulin secretion. 2006 Jul-Aug 2
33 15389641 Transactivation of the epidermal growth factor receptor mediates muscarinic stimulation of focal adhesion kinase in intestinal epithelial cells. 2005 Apr 1
34 15494464 Epidermal growth factor receptor inhibition by tyrphostin 51 induces apoptosis in luteinized granulosa cells. 2005 Jan 3
35 15585324 Epidermal growth factor enhances TNF-alpha-induced priming of human neutrophils. 2005 Jan 31 1
36 15675968 Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes. 2005 Feb 1
37 15710429 Transactivation of the EGF receptor and a PI3 kinase-ATF-1 pathway is involved in the upregulation of NOX1, a catalytic subunit of NADPH oxidase. 2005 Feb 14 1
38 16230389 Down-regulation of integrin alpha2 surface expression by mutant epidermal growth factor receptor (EGFRvIII) induces aberrant cell spreading and focal adhesion formation. 2005 Oct 15 1
39 12829451 Mechanical stretch induces fetal type II cell differentiation via an epidermal growth factor receptor-extracellular-regulated protein kinase signaling pathway. 2004 Jan 1
40 14660604 Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses. 2004 Feb 20 3
41 15213840 The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells. 2004 Jul 1
42 15271882 Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells. 2004 Nov 2
43 15279711 Induction of membrane-type-1 matrix metalloproteinase by epidermal growth factor-mediated signaling in gliomas. 2004 Jul 1
44 15291751 Requirement for G proteins in insulin-like growth factor-I-induced growth of prostate cells. 2004 Aug 1
45 15355899 Ionizing radiation causes a dose-dependent release of transforming growth factor alpha in vitro from irradiated xenografts and during palliative treatment of hormone-refractory prostate carcinoma. 2004 Sep 1 1
46 12388102 p38 mitogen-activated protein kinase inhibits calcium-dependent chloride secretion in T84 colonic epithelial cells. 2003 Feb 1
47 12421825 Proximal events in signaling by plasma membrane estrogen receptors. 2003 Jan 24 1
48 12643788 Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling. 2003 Apr 1
49 12733059 TPA-induced signal transduction: a link between PKC and EGFR signaling modulates the assembly of intercellular junctions in Caco-2 cells. 2003 Jun 1
50 12767057 Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer. 2003 Jul 20 1