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21301589 | Cancer chemotherapy: targeting folic acid synthesis. | 2010 Nov 19 |
1 |
| 52 |
21472308 | Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase in squamous cell carcinoma and basal cell carcinoma of the skin. | 2010 Sep-Oct |
2 |
| 53 |
18851711 | Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis. | 2009 Feb 1 |
1 |
| 54 |
19174154 | Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs. | 2009 Apr 1 |
1 |
| 55 |
19374805 | [Polymorphisms of thymidylate synthase gene detected by RT-PCR-denaturing gradient gel electrophoresis in children with acute leukemia]. | 2009 Apr |
1 |
| 56 |
18406541 | Folate pathway genetic polymorphisms and susceptibility of central nervous system tumors in Thai children. | 2008 |
1 |
| 57 |
18458991 | Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behçet's disease. | 2008 Oct |
1 |
| 58 |
18669903 | Green tea intake, MTHFR/TYMS genotype and breast cancer risk: the Singapore Chinese Health Study. | 2008 Oct |
2 |
| 59 |
17113224 | Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase 1, and colorectal adenoma risk: a Dutch case-control study. | 2007 May 18 |
1 |
| 60 |
17290389 | Thymidylate synthase polymorphisms and colon cancer: associations with tumor stage, tumor characteristics and survival. | 2007 May 15 |
2 |
| 61 |
17308042 | Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications. | 2007 Feb |
1 |
| 62 |
17439323 | Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis risk. | 2007 |
2 |
| 63 |
17446168 | Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway. | 2007 Jun 15 |
1 |
| 64 |
17684410 | Genetic polymorphisms in folate- metabolizing enzymes and risk of gastroesophageal cancers: a potential nutrient-gene interaction in cancer development. | 2007 |
2 |
| 65 |
16010590 | Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells. | 2006 Jan |
2 |
| 66 |
16723031 | Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis. | 2006 May 25 |
2 |
| 67 |
17201138 | Polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR C677T) and thymidylate synthase enhancer region (TSER) as a risk factor of cholangiocarcinoma in a Korean population. | 2006 Nov-Dec |
1 |
| 68 |
15579479 | Case-control analysis of thymidylate synthase polymorphisms and risk of lung cancer. | 2005 Mar |
2 |
| 69 |
15755837 | Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery. | 2005 Mar |
1 |
| 70 |
15817609 | Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status. | 2005 Aug |
1 |
| 71 |
15930032 | Polymorphisms of thymidylate synthase in the 5'- and 3'-untranslated regions associated with risk of gastric cancer in South China: a case-control analysis. | 2005 Oct |
2 |
| 72 |
16010439 | Increased anticancer activity of the thymidylate synthase inhibitor BGC9331 combined with the topoisomerase I inhibitor SN-38 in human colorectal and breast cancer cells: induction of apoptosis and ROCK cleavage through caspase-3-dependent and -independent mechanisms. | 2005 Aug |
1 |
| 73 |
16045580 | Association of methylenetetrahydrofolate reductase and thymidylate synthase promoter polymorphisms with genetic susceptibility to esophageal and cardia cancer in a Chinese high-risk population. | 2005 |
1 |
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16178783 | Thymidylate synthase structure, function and implication in drug discovery. | 2005 |
1 |
| 75 |
16207145 | Pharmacogenetics of folate-related drug targets in cancer treatment. | 2005 Oct |
1 |
| 76 |
15198953 | Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma. | 2004 Oct 1 |
1 |
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15225321 | The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. | 2004 Jul |
4 |
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15244514 | Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking. | 2004 Apr-Jun |
1 |
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15339053 | New investigative regimens and cytotoxic agents in thoracic cancers: gemcitabine and pemetrexed. | 2004 Jul |
1 |
| 80 |
15510613 | Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype. | 2004 Sep-Oct |
1 |
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15585623 | Thymidylate synthase 5'- and 3'-untranslated region polymorphisms associated with risk and progression of squamous cell carcinoma of the head and neck. | 2004 Dec 1 |
2 |
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12684658 | Chromosomal imbalance maps of human 5FU-resistant colorectal cancer cell lines: implications in the analysis of 5FU-acquired resistance mechanisms. | 2003 May |
3 |
| 83 |
12684695 | Polymorphisms in the thymidylate synthase and methylenetetrahydrofolate reductase genes and sensitivity to the low-dose methotrexate therapy in patients with rheumatoid arthritis. | 2003 May |
1 |
| 84 |
12839949 | Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor. | 2003 Jul 1 |
1 |
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14529544 | Anticancer antifolates: current status and future directions. | 2003 |
1 |
| 86 |
14578129 | Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. | 2003 Oct |
3 |
| 87 |
14676127 | Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. | 2003 Dec 1 |
1 |
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14745930 | Associations between polymorphisms within the thymidylate synthase gene and spina bifida. | 2003 Nov |
2 |
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12023790 | Pemetrexed for diffuse malignant pleural mesothelioma. | 2002 Apr |
1 |
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12052139 | Pharmacogenetics and folate metabolism -- a promising direction. | 2002 May |
1 |
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12067974 | Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. | 2002 Jun 15 |
2 |
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12084459 | Thymidylate synthase as a translational regulator of cellular gene expression. | 2002 Jul 18 |
2 |
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12084461 | Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. | 2002 Jul 18 |
1 |
| 94 |
12167486 | Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase. | 2002 Aug 15 |
2 |
| 95 |
12215845 | Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. | 2002 Sep |
5 |
| 96 |
12449732 | Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil. | 2002 |
2 |
| 97 |
11325838 | Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. | 2001 May 1 |
1 |
| 98 |
11509884 | Murine cytomegalovirus infection induces cellular folylpolyglutamate synthetase activity in quiescent cells. | 2001 |
3 |
| 99 |
11524555 | Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. | 2001 |
1 |
| 100 |
11774738 | Antifolate resistance and its circumvention by new analogues. | 2001 Sep |
1 |