| 1 |
35253073 | Dihydrofolate reductase, thymidylate synthase, and serine hydroxy methyltransferase: successful targets against some infectious diseases. | 2022 Mar 7 |
1 |
| 2 |
33391382 | Variants of Genes Involved in Metabolism of Folate Among Patients with Breast Cancer: Association of TYMS 3R Allele with Susceptibility to Breast Cancer and Metastasis. | 2021 Winter |
1 |
| 3 |
33710891 | Folic Acid-Peptide Conjugates Combine Selective Cancer Cell Internalization with Thymidylate Synthase Dimer Interface Targeting. | 2021 Mar 25 |
2 |
| 4 |
33809325 | The 3'-UTR Polymorphisms in the Thymidylate Synthase (TS) Gene Associated with the Risk of Ischemic Stroke and Silent Brain Infarction. | 2021 Mar 12 |
1 |
| 5 |
31739736 | Acceleration of interstitial lung disease induced by raltitrexed. | 2020 Jul |
1 |
| 6 |
30572970 | Thymidylate synthase gene variation is associated with the risk for conotruncal heart defects in Chinese population. | 2019 Mar |
1 |
| 7 |
31542479 | DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide. | 2019 Nov 15 |
3 |
| 8 |
31873125 | Structural basis of methotrexate and pemetrexed action on serine hydroxymethyltransferases revealed using plant models. | 2019 Dec 23 |
1 |
| 9 |
29162511 | The thymidylate synthase enhancer region (TSER) polymorphism increases the risk of thymic lymphoid hyperplasia in patients with Myasthenia Gravis. | 2018 Feb 5 |
2 |
| 10 |
29360079 | [4pp Mucocutaneous manifestations of methotrexate toxicity]. | 2018 |
1 |
| 11 |
29922516 | A novel thymidylate synthase from the Vibrionales, Alteromonadales, Aeromonadales, and Pasteurellales (VAAP) clade with altered nucleotide and folate binding sites. | 2018 |
1 |
| 12 |
28043790 | Thymidylate synthase gene polymorphisms as important contributors affecting hepatocellular carcinoma prognosis. | 2017 Jun |
2 |
| 13 |
28338744 | Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR. | 2017 Mar 1 |
2 |
| 14 |
28685068 | Protein and mRNA expression of folic acid-associated enzymes as biomarkers for the cytotoxicity of the thymidylate synthase-targeted drugs, pemetrexed and S-1, in non-small cell lung cancer. | 2017 Jul |
3 |
| 15 |
28939595 | Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants. | 2017 Nov |
2 |
| 16 |
29321350 | Neuro-fuzzy model of homocysteine metabolism. | 2017 Dec |
1 |
| 17 |
26096018 | Substrate channeling between the human dihydrofolate reductase and thymidylate synthase. | 2016 Jan |
1 |
| 18 |
26438060 | Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults. | 2016 Mar |
6 |
| 19 |
27637357 | Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action. | 2016 Oct |
2 |
| 20 |
24166930 | Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ≤ 55 years. | 2015 Apr |
2 |
| 21 |
24756984 | Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer. | 2015 Sep |
2 |
| 22 |
25245820 | Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. | 2015 Jan |
1 |
| 23 |
25668494 | Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidines as potential nonclassical antifolates targeting both thymidylate and purine nucleotide biosynthesis. | 2015 Mar 26 |
1 |
| 24 |
24771227 | Reduced folate carrier-1 G80a gene polymorphism is associated with neuroblastoma's development. | 2014 Aug |
1 |
| 25 |
25066213 | Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk. | 2014 Oct |
1 |
| 26 |
25341694 | Tyms double (2R) and triple repeat (3R) confers risk for human oral squamous cell carcinoma. | 2014 Dec |
1 |
| 27 |
22147344 | Oxidative stress is associated with genetic polymorphisms in one-carbon metabolism in coronary artery disease. | 2013 Nov |
1 |
| 28 |
23336575 | Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia. | 2013 Feb |
2 |
| 29 |
23449276 | Reduced folate carrier and folylpolyglutamate synthetase, but not thymidylate synthase predict survival in pemetrexed-treated patients suffering from malignant pleural mesothelioma. | 2013 May |
1 |
| 30 |
23611499 | Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. | 2013 May 22 |
1 |
| 31 |
23726796 | Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma. | 2013 Aug |
1 |
| 32 |
23893618 | Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study. | 2013 Oct |
1 |
| 33 |
24053355 | First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling. | 2013 Oct 15 |
2 |
| 34 |
21848426 | Polymorphisms of folate pathway enzymes (methylenetetrahydrofolate reductase and thymidylate synthase) and their relationship with thymidylate synthase expression in human astrocytic tumors. | 2012 Jan |
2 |
| 35 |
22307944 | The association between two polymorphisms in the TS gene and risk of cancer: a systematic review and pooled analysis. | 2012 Nov 1 |
2 |
| 36 |
22484375 | Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. | 2012 Jun 10 |
1 |
| 37 |
22537194 | Molecular mechanism implicated in Pemetrexed-induced apoptosis in human melanoma cells. | 2012 Apr 26 |
1 |
| 38 |
22576918 | Thymidylate synthase enhancer region polymorphism not related to susceptibility to acute lymphoblastic leukemia in the Kashmir population. | 2012 Apr 10 |
2 |
| 39 |
23019356 | Folate binding site of flavin-dependent thymidylate synthase. | 2012 Sep 25 |
1 |
| 40 |
20177420 | Prediction of irinotecan and 5-fluorouracil toxicity and response in patients with advanced colorectal cancer. | 2011 Feb |
2 |
| 41 |
21748308 | Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia. | 2011 Sep |
1 |
| 42 |
22023442 | Folate metabolic pathways in Leishmania. | 2011 |
2 |
| 43 |
19360465 | BRCA1-associated breast and ovarian cancer risks in Poland: no association with commonly studied polymorphisms. | 2010 Jan |
1 |
| 44 |
19839928 | Predictive markers for haematological toxicity of pemetrexed. | 2010 Jan |
1 |
| 45 |
19839929 | The role of pemetrexed in advanced non small-cell lung cancer: special focus on pharmacology and mechanism of action. | 2010 Jan |
3 |
| 46 |
19998340 | Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma. | 2010 Aug 15 |
2 |
| 47 |
20544798 | Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women. | 2010 Aug |
2 |
| 48 |
20571234 | Thymidylate synthase gene polymorphisms effecting 5-FU response in breast cancer patients. | 2010 |
2 |
| 49 |
21159649 | Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. | 2010 Dec 15 |
1 |
| 50 |
21209714 | CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy. | 2010 |
1 |