| 1 |
34502300 | MTHFR Knockdown Assists Cell Defense against Folate Depletion Induced Chromosome Segregation and Uracil Misincorporation in DNA. | 2021 Aug 30 |
1 |
| 2 |
31807868 | In vitro apoptotic effect on human lymphatic filarial parasite by piperidine derivatives and thymidine reversal study. | 2020 Jan |
1 |
| 3 |
30142195 | Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer. | 2018 |
2 |
| 4 |
27655645 | Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging. | 2017 Apr 11 |
2 |
| 5 |
28927061 | 5FU resistance caused by reduced fluoro-deoxyuridine monophosphate and its reversal using deoxyuridine. | 2017 Sep |
1 |
| 6 |
29137296 | Early detection of thymidylate synthase resistance in non-small cell lung cancer with FLT-PET imaging. | 2017 Oct 10 |
1 |
| 7 |
29324220 | 5-fluorouracil Toxicity Mechanism Determination in Human Keratinocytes: in vitro Study on HaCaT Cell Line. | 2017 |
1 |
| 8 |
27391433 | Dasatinib modulates sensitivity to pemetrexed in malignant pleural mesothelioma cell lines. | 2016 Nov 22 |
2 |
| 9 |
26242737 | Dihydrofolate Reductase and Thymidylate Synthase Transgenes Resistant to Methotrexate Interact to Permit Novel Transgene Regulation. | 2015 Sep 18 |
2 |
| 10 |
25423174 | Analysis of mRNA recognition by human thymidylate synthase. | 2014 Dec 23 |
1 |
| 11 |
23449220 | Development of modified siRNA molecules incorporating 5-fluoro-2'-deoxyuridine residues to enhance cytotoxicity. | 2013 Apr |
3 |
| 12 |
23611499 | Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site. | 2013 May 22 |
2 |
| 13 |
23143777 | Targeting a regulatory element in human thymidylate synthase mRNA. | 2012 Dec 21 |
2 |
| 14 |
21222488 | Transition state analysis of the arsenolytic depyrimidination of thymidine by human thymidine phosphorylase. | 2011 Mar 1 |
2 |
| 15 |
21247442 | Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors. | 2011 Jan 19 |
2 |
| 16 |
21269855 | Thymidylate synthase gene polymorphisms and markers of DNA methylation capacity. | 2011 Apr |
2 |
| 17 |
21498882 | Analysis of coevolving gene families using mutually exclusive orthologous modules. | 2011 |
1 |
| 18 |
21673071 | Combining small interfering RNAs targeting thymidylate synthase and thymidine kinase 1 or 2 sensitizes human tumor cells to 5-fluorodeoxyuridine and pemetrexed. | 2011 Sep |
1 |
| 19 |
19839928 | Predictive markers for haematological toxicity of pemetrexed. | 2010 Jan |
1 |
| 20 |
20628382 | Identification of thymidylate synthase as a potential therapeutic target for lung cancer. | 2010 Jul 27 |
2 |
| 21 |
18442042 | Thymidylate synthase in situ protein expression and survival in stage I nonsmall-cell lung cancer. | 2008 Jun 15 |
2 |
| 22 |
19006382 | Activation of p16 gene silenced by DNA methylation in cancer cells by phosphoramidate derivatives of 2'-deoxyzebularine. | 2008 Dec 11 |
2 |
| 23 |
16721548 | An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed. | 2007 Feb |
3 |
| 24 |
16568206 | Elevation of radiolabelled thymidine uptake in RIF-1 fibrosarcoma and HT29 colon adenocarcinoma cells after treatment with thymidylate synthase inhibitors. | 2006 Sep |
1 |
| 25 |
15711180 | Determinants of trifluorothymidine sensitivity and metabolism in colon and lung cancer cells. | 2005 Mar |
1 |
| 26 |
15207728 | The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdR. | 2004 Jul 16 |
1 |
| 27 |
15342418 | P21Cip1 is a critical mediator of the cytotoxic action of thymidylate synthase inhibitors in colorectal carcinoma cells. | 2004 Sep 1 |
1 |
| 28 |
11862424 | Synergistic cytotoxic effect between serine-threonine phosphatase inhibitors and 5-fluorouracil: a novel concept for modulation of cytotoxic effect. | 2002 Feb |
2 |
| 29 |
12102601 | The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger. | 2002 Aug |
2 |
| 30 |
11216535 | Preclinical evaluation of locoregional delivery of radiolabeled iododeoxyuridine and thymidylate synthase inhibitor in a hepatoma model. | 2001 Feb |
1 |
| 31 |
11325838 | Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors. | 2001 May 1 |
1 |
| 32 |
11727827 | Interaction of thymidylate synthase with the 5'-thiophosphates, 5'-dithiophosphates, 5'-H-phosphonates and 5'-S-thiosulfates of 2'-deoxyuridine, thymidine and 5-fluoro-2'-deoxyuridine. | 2001 Oct |
1 |
| 33 |
12467230 | Combination of thymidine phosphorylase gene transfer and deoxyinosine treatment greatly enhances 5-fluorouracil antitumor activity in vitro and in vivo. | 2001 Dec |
1 |
| 34 |
10663629 | Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy. | 2000 |
1 |
| 35 |
10473074 | Suicide prodrugs activated by thymidylate synthase: rationale for treatment and noninvasive imaging of tumors with deoxyuridine analogues. | 1999 Aug |
1 |
| 36 |
10482907 | Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. | 1999 Aug |
2 |
| 37 |
10509749 | Genetic complementation and resistance to 5-fluoro-2'-deoxyuridine in thymidine auxotrophs expressing a highly defective mutant of human thymidylate synthase. | 1999 Sep 15 |
6 |
| 38 |
10535743 | Isolation and characterization of a thymidylate synthase-deficient human colon tumor cell line. | 1999 Nov 15 |
1 |
| 39 |
10598557 | Prevention of thymidine and hypoxanthine rescue from MTA (LY231514) growth inhibition by dipyridamole in human lung cancer cell lines. | 1999 Apr |
1 |
| 40 |
9661884 | Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro. | 1998 Jul 1 |
2 |
| 41 |
7575641 | Studies on the antitumor effects of analogues of 5,8-dideazaisofolic acid and 5,8-dideazaisoaminopterin. | 1995 Sep 7 |
1 |
| 42 |
7605345 | Biochemical modulation of iododeoxyuridine by N6-[4-(morpholinosulfonyl)benzyl]-N6-methyl-2,6-diaminobenz[cd]indole glucuronate (AG-331) leading to enhanced cytotoxicity. | 1995 Jun 29 |
2 |
| 43 |
7942285 | Modulation of target enzyme associated with the action of antifolates. | 1994 |
1 |
| 44 |
8203840 | Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase. | 1994 Mar |
1 |
| 45 |
8246876 | [Thymidine kinase and thymidylate synthetase activities in human gastric cancer]. | 1993 Sep |
1 |
| 46 |
8325888 | The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme. | 1993 Jul 15 |
1 |
| 47 |
8385896 | Inhibitors of thymidylate synthase and dihydrofolate reductase potentiate the antiviral effect of acyclovir. | 1993 Mar |
1 |
| 48 |
8398696 | In vitro antitumour activity of cis- and trans-5-fluoro-5,6-dihydro-6-alkoxy-uracils; effects on thymidylate synthesis. | 1993 Oct |
2 |
| 49 |
8428362 | Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. | 1993 Feb 15 |
1 |
| 50 |
1390771 | Structural basis for recognition of polyglutamyl folates by thymidylate synthase. | 1992 Oct 20 |
2 |