| 51 |
16685161 | [Thymidylate synthase and dihydropyrimidine dehydrogenase expression and histological effects of preoperative UFT in gastric cancer patients]. | 2006 May |
1 |
| 52 |
16723031 | Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis. | 2006 May 25 |
2 |
| 53 |
17004711 | Antibacterial agent discovery using thymidylate synthase biolibrary screening. | 2006 Oct 5 |
1 |
| 54 |
15817609 | Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status. | 2005 Aug |
2 |
| 55 |
14967037 | Structural determinants for the intracellular degradation of human thymidylate synthase. | 2004 Feb 24 |
1 |
| 56 |
15598787 | Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas. | 2004 Dec |
2 |
| 57 |
12488549 | Detection of thymidylate synthase modulators by a novel screening assay. | 2003 Jan |
2 |
| 58 |
12536082 | Expression of thymidylate synthase and thymidine phosphorylase in human breast carcinoma: implication for method to detect expression of these molecules in clinic. | 2003 Feb 10 |
2 |
| 59 |
12565992 | Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition. | 2003 Feb |
2 |
| 60 |
12616366 | Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in thymoma. | 2003 |
2 |
| 61 |
12684419 | Significance of thymidylate synthase activity in renal cell carcinoma. | 2003 Apr |
1 |
| 62 |
12791246 | Complementing thymidylate synthase. | 2003 Jun |
1 |
| 63 |
12819937 | Thymidylate synthase inhibitors as anticancer agents: from bench to bedside. | 2003 Jul |
2 |
| 64 |
12859954 | Kinetic properties of human thymidylate synthase, an anticancer drug target. | 2003 Jul 25 |
1 |
| 65 |
12948860 | Methionine restriction selectively targets thymidylate synthase in prostate cancer cells. | 2003 Sep 1 |
2 |
| 66 |
14578129 | Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer. | 2003 Oct |
2 |
| 67 |
11914638 | Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011. | 2002 Jan |
1 |
| 68 |
12084461 | Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism. | 2002 Jul 18 |
4 |
| 69 |
12147691 | Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. | 2002 Sep 27 |
2 |
| 70 |
12215845 | Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels. | 2002 Sep |
2 |
| 71 |
11212266 | Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase. | 2001 Jan 15 |
1 |
| 72 |
11278511 | Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors. | 2001 Apr 27 |
1 |
| 73 |
11316879 | Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. | 2001 May |
3 |
| 74 |
11329255 | Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug. | 2001 Feb 20 |
1 |
| 75 |
11487279 | The ability to accumulate deoxyuridine triphosphate and cellular response to thymidylate synthase (TS) inhibition. | 2001 Aug 3 |
2 |
| 76 |
11505394 | Prognostic significance of thymidylate synthase activity in bladder carcinoma. | 2001 Aug 1 |
2 |
| 77 |
11605654 | Pyrrolo[2,3-d]pyrimidine thymidylate synthase inhibitors: design and synthesis of one-carbon bridge derivatives. | 2001 Oct |
2 |
| 78 |
11913730 | Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. | 2001 |
2 |
| 79 |
12374095 | The role of dUTPase and uracil-DNA repair in cancer chemotherapy. | 2001 Dec |
2 |
| 80 |
10653645 | Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of "effective charge balance". | 2000 Feb 8 |
1 |
| 81 |
10915553 | Different Activities of 5-Hydroxy-dUMP and 5-Hydroxymethyl-dUMP in Thymidylate Synthase-Catalyzed Reaction in View of Molecular Modeling and Structural Studies. | 2000 Jun |
3 |
| 82 |
10509749 | Genetic complementation and resistance to 5-fluoro-2'-deoxyuridine in thymidine auxotrophs expressing a highly defective mutant of human thymidylate synthase. | 1999 Sep 15 |
3 |
| 83 |
9463483 | Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma. | 1998 Feb |
1 |
| 84 |
9540799 | Crystal structures of 5-fluoro-dUrd and its 2 and/or 4-thio analogues: models of substituted dUMP pyrimidine ring interacting with thymidylate synthase. | 1998 Feb 17 |
1 |
| 85 |
9668195 | Nonpolyglutamatable antifolates as inhibitors of thymidylate synthase (TS) and potential antitumour agents. | 1998 Aug |
2 |
| 86 |
9748254 | Random sequence mutagenesis and resistance to 5-fluorouridine in human thymidylate synthases. | 1998 Oct 2 |
1 |
| 87 |
9821803 | Cloning and characterization of the promoter region of monkey thymidylate synthase gene. | 1998 Oct |
2 |
| 88 |
9048572 | Active site general catalysts are not necessary for some proton transfer reactions of thymidylate synthase. | 1997 Feb 18 |
2 |
| 89 |
9256160 | Cross-resistance to antifolates in multidrug resistant cell lines with P-glycoprotein or multidrug resistance protein expression. | 1997 Jun 15 |
2 |
| 90 |
9535167 | Thymidylate synthase: structure, inhibition, and strained conformations during catalysis. | 1997 Oct-Dec |
2 |
| 91 |
8611496 | Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. | 1996 Apr 23 |
1 |
| 92 |
8672425 | Asparagine 229 mutants of thymidylate synthase catalyze the methylation of 3-methyl-2'-deoxyuridine 5'-monophosphate. | 1996 Apr 2 |
2 |
| 93 |
8787551 | Resistance to tomudex (ZD1694): multifactorial in human breast and colon carcinoma cell lines. | 1996 May 17 |
2 |
| 94 |
8790719 | Molecular mechanism of thymidylate synthase-catalyzed reaction and interaction of the enzyme with 2- and/or 4-substituted analogues of dUMP and 5-fluoro-dUMP. | 1996 |
2 |
| 95 |
7574499 | The catalytic mechanism and structure of thymidylate synthase. | 1995 |
2 |
| 96 |
7623777 | Biphasic binding of 5-fluoro-2'-deoxyuridylate to human thymidylate synthase. | 1995 Jul |
1 |
| 97 |
7647337 | Difference in thymidylate synthetase activity in involved nodes compared with primary tumor in breast cancer patients. | 1995 Aug |
1 |
| 98 |
7779704 | Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells. | 1995 Jun |
2 |
| 99 |
8086425 | Phosphorus-31 nuclear magnetic resonance studies of complexes of thymidylate synthase. | 1994 Sep 21 |
2 |
| 100 |
8294436 | Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites. | 1994 Jan 21 |
1 |