| 1 |
35427566 | Cinobufagin restrains the growth and triggers DNA damage of human hepatocellular carcinoma cells via proteasome-dependent degradation of thymidylate synthase. | 2022 Jun 1 |
2 |
| 2 |
33486616 | Backbone and ILVM methyl resonance assignments of human thymidylate synthase in apo and substrate bound forms. | 2021 Apr |
2 |
| 3 |
33829766 | Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog. | 2021 Apr 27 |
6 |
| 4 |
32715203 | dUMP/F-dUMP Binding to Thymidylate Synthase: Human Versus Mycobacterium tuberculosis. | 2020 Jul 21 |
3 |
| 5 |
30180988 | Polymorphism rs3819102 in thymidylate synthase and environmental factors: effects on lung cancer in Chinese population. | 2019 Feb |
2 |
| 6 |
30574873 | Disparate effects of cytotoxic chemotherapy on the antiviral activity of antiretroviral therapy: implications for treatments of HIV-infected cancer patients. | 2019 |
1 |
| 7 |
30935102 | Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities. | 2019 Mar 31 |
1 |
| 8 |
31500803 | Positive Cooperativity in Substrate Binding by Human Thymidylate Synthase. | 2019 Sep 17 |
2 |
| 9 |
29735940 | New Insight into the Octamer of TYMS Stabilized by Intermolecular Cys43-Disulfide. | 2018 May 7 |
3 |
| 10 |
28796306 | Enzyme Activation with a Synthetic Catalytic Co-enzyme Intermediate: Nucleotide Methylation by Flavoenzymes. | 2017 Oct 2 |
1 |
| 11 |
27026843 | Non-covalent interactions involving halogenated derivatives of capecitabine and thymidylate synthase: a computational approach. | 2016 |
1 |
| 12 |
27214228 | Deprotonations in the Reaction of Flavin-Dependent Thymidylate Synthase. | 2016 Jun 14 |
2 |
| 13 |
27936107 | Structural Analysis of Thymidylate Synthase from Kaposi's Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed. | 2016 |
2 |
| 14 |
25562513 | Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine. | 2015 Mar |
1 |
| 15 |
25581782 | Targeting the de novo biosynthesis of thymidylate for the development of a PET probe for pancreatic cancer imaging. | 2015 Feb 10 |
2 |
| 16 |
25912171 | The general base in the thymidylate synthase catalyzed proton abstraction. | 2015 Dec 14 |
2 |
| 17 |
25997777 | Thymidylate synthase inspired biomodel reagent for the conversion of uracil to thymine. | 2015 Jun 21 |
1 |
| 18 |
26443810 | Oxidative Stress and Response to Thymidylate Synthase-Targeted Antimetabolites. | 2015 Dec |
4 |
| 19 |
26745074 | Thymidylate Synthase Polymorphisms and Risk of Lung Cancer among the Jordanian Population: a Case Control Study. | 2015 |
1 |
| 20 |
23239172 | Computational study of the effects of protein tyrosine nitrations on the catalytic activity of human thymidylate synthase. | 2013 Jan |
1 |
| 21 |
23314484 | Pharmacodynamic assay of thymidylate synthase activity in peripheral blood mononuclear cells. | 2013 Mar |
2 |
| 22 |
23404871 | Thymidylate synthase polymorphisms and risks of human orofacial clefts. | 2013 Feb |
2 |
| 23 |
23705822 | Effect of halogen substitutions on dUMP to stability of thymidylate synthase/dUMP/mTHF ternary complex using molecular dynamics simulation. | 2013 Jun 24 |
2 |
| 24 |
23726796 | Overexpression of thymidylate synthetase confers an independent prognostic indicator in nasopharyngeal carcinoma. | 2013 Aug |
1 |
| 25 |
24147825 | 2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives. | 2013 Nov 27 |
1 |
| 26 |
24460328 | A novel approach to cloning and expression of human thymidylate synthase. | 2013 |
1 |
| 27 |
24563811 | Flavin-Dependent Thymidylate Synthase as a Drug Target for Deadly Microbes: Mutational Study and a Strategy for Inhibitor Design. | 2013 Apr 20 |
1 |
| 28 |
22307944 | The association between two polymorphisms in the TS gene and risk of cancer: a systematic review and pooled analysis. | 2012 Nov 1 |
2 |
| 29 |
23019356 | Folate binding site of flavin-dependent thymidylate synthase. | 2012 Sep 25 |
1 |
| 30 |
21188629 | The association between two polymorphisms in the TYMS gene and breast cancer risk: a meta-analysis. | 2011 Jul |
2 |
| 31 |
21206062 | Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. | 2011 Jan |
1 |
| 32 |
21222484 | Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA. | 2011 Feb 8 |
1 |
| 33 |
21742238 | [A brief overview of a lung cancer biomarker: thymidylate synthase]. | 2011 Jun |
2 |
| 34 |
21832075 | Novel positron emission tomography tracer distinguishes normal from cancerous cells. | 2011 Sep 30 |
1 |
| 35 |
21876188 | Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria. | 2011 Sep 13 |
2 |
| 36 |
20580582 | Influence of thymidylate synthase gene polymorphisms on total plasma homocysteine concentrations. | 2010 Sep |
2 |
| 37 |
20651387 | Polymorphisms of thymidylate synthase gene 5'- and 3'-untranslated region and risk of gastric cancer in Koreans. | 2010 Jun |
2 |
| 38 |
20725619 | Analysis of the thymidylate synthase gene structure in colorectal cancer patients and its possible relation with the 5-Fluorouracil drug response. | 2010 Jan 26 |
1 |
| 39 |
21131780 | Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase. | 2010 Dec 15 |
1 |
| 40 |
19370033 | An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene. | 2009 Apr 16 |
1 |
| 41 |
19374805 | [Polymorphisms of thymidylate synthase gene detected by RT-PCR-denaturing gradient gel electrophoresis in children with acute leukemia]. | 2009 Apr |
2 |
| 42 |
19797058 | The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway. | 2009 Nov 13 |
2 |
| 43 |
18362071 | A molecular modeling study of the interaction of 2'-fluoro-substituted analogues of dUMP/FdUMP with thymidylate synthase. | 2008 Apr 15 |
2 |
| 44 |
18589584 | [Frequency of TS1494del6 polymorphism in colorectal patients from west of Mexico]. | 2008 Jan-Feb |
2 |
| 45 |
18790783 | Novel opportunities for thymidylate metabolism as a therapeutic target. | 2008 Sep |
1 |
| 46 |
21479480 | 5' and 3' UTR thymidylate synthase polymorphisms modulate the risk of colorectal cancer independently of the intake of methyl group donors. | 2008 Sep-Oct |
1 |
| 47 |
17275316 | The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR. | 2007 Mar 15 |
1 |
| 48 |
17692822 | Interactions of 2'-fluoro-substituted dUMP analogues with thymidylate synthase. | 2007 Oct 12 |
2 |
| 49 |
16259621 | Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase. | 2006 Feb 15 |
2 |
| 50 |
16489621 | Significance of thymidylate synthase gene expression level in patients with adenocarcinoma of the lung. | 2006 Apr 1 |
4 |