| 1 |
33188383 | Systemic delivery of aptamer-drug conjugates for cancer therapy using enzymatically generated self-assembled DNA nanoparticles. | 2020 Nov 26 |
1 |
| 2 |
29117941 | Loss of Uracil DNA Glycosylase Selectively Resensitizes p53-Mutant and -Deficient Cells to 5-FdU. | 2018 Feb |
1 |
| 3 |
27517750 | Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage. | 2016 Sep 13 |
3 |
| 4 |
21222484 | Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA. | 2011 Feb 8 |
2 |
| 5 |
21247442 | Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors. | 2011 Jan 19 |
2 |
| 6 |
21673071 | Combining small interfering RNAs targeting thymidylate synthase and thymidine kinase 1 or 2 sensitizes human tumor cells to 5-fluorodeoxyuridine and pemetrexed. | 2011 Sep |
4 |
| 7 |
19694534 | Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells. | 2009 Dec |
6 |
| 8 |
17605297 | Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs. | 2007 |
2 |
| 9 |
15322254 | Small interfering RNA-mediated suppression of dUTPase sensitizes cancer cell lines to thymidylate synthase inhibition. | 2004 Sep |
1 |
| 10 |
12679800 | A "combination oligonucleotide" antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance. | 2003 Apr |
1 |
| 11 |
12027413 | Thymidylate Synthase expression as a predictor of clinical response to fluoropyrimidine-based chemotherapy in advanced colorectal cancer. | 2002 Feb |
2 |
| 12 |
12102601 | The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger. | 2002 Aug |
6 |
| 13 |
12147691 | Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. | 2002 Sep 27 |
3 |
| 14 |
11212266 | Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase. | 2001 Jan 15 |
1 |
| 15 |
11435585 | Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. | 2001 Aug |
1 |
| 16 |
11724749 | Antisense-induced down-regulation of thymidylate synthase and enhanced cytotoxicity of 5-FUdR in 5-FUdR-resistant HeLa cells. | 2001 Dec |
2 |
| 17 |
12450432 | Thymidylate synthase pharmacogenetics in colorectal cancer. | 2001 Nov |
4 |
| 18 |
10847455 | Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors. | 2000 Apr |
1 |
| 19 |
10975679 | Escherichia coli thymidylate synthase expression protects human cells from the cytotoxic effects of 5-fluorodeoxyuridine more effectively than human thymidylate synthase overexpression. | 2000 Aug |
2 |
| 20 |
10037181 | Colorectal liver metastasis thymidylate synthase staining correlates with response to hepatic arterial floxuridine. | 1999 Feb |
2 |
| 21 |
10482907 | Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. | 1999 Aug |
1 |
| 22 |
10545786 | Thymidylate synthase: a target for combination therapy and determinant of chemotherapeutic response in colorectal cancer. | 1999 Oct |
1 |
| 23 |
9113088 | Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in HCT-8 human ileocecal carcinoma cells. | 1997 Mar 7 |
1 |
| 24 |
7987994 | Phase I study of 5-day continuous infusion fluorodeoxyuridine and high-dose folinic acid with oral hydroxyurea. | 1994 |
2 |
| 25 |
8324744 | bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. | 1993 Jul 15 |
1 |
| 26 |
8502227 | Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine. | 1993 May |
1 |
| 27 |
1532343 | Radiosensitization by fluorodeoxyuridine: effects of thymidylate synthase inhibition and cell synchronization. | 1992 Apr 1 |
2 |
| 28 |
1828191 | Five-day infusion of fluorodeoxyuridine with high-dose oral leucovorin: a phase I study. | 1991 |
2 |
| 29 |
2947954 | Comparison of the inhibitory effects of hydroxyurea, 5-fluorodeoxyuridine, 3,4-dihydroxybenzylamine, and methotrexate on human squamous cell carcinoma. | 1987 Jan |
2 |
| 30 |
2931977 | Fragile (X) expression induced by FUdR is transient and inversely related to levels of thymidylate synthase activity. | 1985 Sep |
4 |
| 31 |
2932632 | Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. | 1985 Nov |
1 |
| 32 |
6213845 | Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells. | 1982 May |
2 |