2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one

ATM serine/threonine kinase ; Homo sapiens







102 Article(s)
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1 33742560 Phenformin and ataxia-telangiectasia mutated inhibitors synergistically co-suppress liver cancer cell growth by damaging mitochondria. 2021 May 4
2 33743824 Cooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing's sarcoma cells. 2021 Mar 20 1
3 33845224 Mechanism of thorium-nitrate and thorium-dioxide induced cytotoxicity in normal human lung epithelial cells (WI26): Role of oxidative stress, HSPs and DNA damage. 2021 Jul 15 1
4 34068585 Downregulation of ATM and BRCA1 Predicts Poor Outcome in Head and Neck Cancer: Implications for ATM-Targeted Therapy. 2021 May 10 1
5 34556870 Molecular basis of human ATM kinase inhibition. 2021 Oct 1
6 34784199 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Histone Acetylation via α7nAChR-Mediated PI3K/Akt Activation and Its Impact on γ-H2AX Generation. 2021 Dec 20 1
7 32517809 A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastrophe. 2020 Jun 9 2
8 32743653 Decreased activation of ataxia telangiectasia mutated (ATM) in monocytes from patients with systemic sclerosis. 2020 Dec 1 2
9 33338048 ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines. 2020 1
10 30964658 Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. 2019 Jun 17 1
11 31299316 ATM in DNA repair in cancer. 2019 Nov 1
12 31362335 Co-Inhibition of the DNA Damage Response and CHK1 Enhances Apoptosis of Neuroblastoma Cells. 2019 Jul 29 1
13 29186352 ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage. 2018 Feb 1 2
14 29235570 Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeutic strategy in cutaneous melanoma. 2018 Feb 20 2
15 29396516 RAP80 is an independent prognosis biomarker for the outcome of patients with esophageal squamous cell carcinoma. 2018 Feb 2 2
16 29845714 miRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation. 2018 Aug 1
17 29849127 Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway. 2018 Oct 1
18 30265735 Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage. 2018 1
19 28182994 ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib. 2017 Apr 1
20 28202068 The DNA damage response promotes polyomavirus JC infection by nucleus to cytoplasm NF- kappaB activation. 2017 Feb 15 1
21 28341201 The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D. 2017 Jun 1
22 28387728 Microvesicles Contribute to the Bystander Effect of DNA Damage. 2017 Apr 7 1
23 28418119 Endoplasmic reticulum stress pathway PERK-eIF2α confers radioresistance in oropharyngeal carcinoma by activating NF-κB. 2017 Jul 1
24 28544661 Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity. 2017 Jun 1
25 28638267 Synergistic Antitumor Effect of Sorafenib in Combination with ATM Inhibitor in Hepatocellular Carcinoma Cells. 2017 1
26 29111814 Sarsaparilla (Smilax Glabra Rhizome) Extract Activates Redox-Dependent ATM/ATR Pathway to Inhibit Cancer Cell Growth by S Phase Arrest, Apoptosis, and Autophagy. 2017 Nov-Dec 1
27 29241579 Punicalagin from pomegranate promotes human papillary thyroid carcinoma BCPAP cell death by triggering ATM-mediated DNA damage response. 2017 Nov 2
28 26442630 Induction of ROS-independent DNA damage by curcumin leads to G2/M cell cycle arrest and apoptosis in human papillary thyroid carcinoma BCPAP cells. 2016 Jan 1
29 26636375 Tetraploidization or autophagy: The ultimate fate of senescent human endometrial stem cells under ATM or p53 inhibition. 2016 1
30 26851027 ER-Dependent Ca++-mediated Cytosolic ROS as an Effector for Induction of Mitochondrial Apoptotic and ATM-JNK Signal Pathways in Gallic Acid-treated Human Oral Cancer Cells. 2016 Feb 1
31 27047993 Chloroquine increases phosphorylation of AMPK and Akt in myotubes. 2016 Mar 1
32 27087371 [Jaridonin, a new diterpenoid from Isodon rubescens, induces cell cycle arrest in gastric cancer cells through activating ataxia telangiectasia mutated kinase]. 2016 Apr 1
33 27089984 ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. 2016 Apr 19 1
34 27108928 Linking loss of sodium-iodide symporter expression to DNA damage. 2016 May 15 1
35 27551505 Induction and inhibition of the pan-nuclear gamma-H2AX response in resting human peripheral blood lymphocytes after X-ray irradiation. 2016 2
36 27829214 PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway. 2016 Dec 13 2
37 25205037 Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase. 2015 Jan 1
38 25585815 The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect. 2015 Apr 4
39 25598069 Role of ataxia-telangiectasia mutated (ATM) in porcine oocyte in vitro maturation. 2015 Jun 1
40 25766900 Late-responding normal tissue cells benefit from high-precision radiotherapy with prolonged fraction delivery times via enhanced autophagy. 2015 Mar 13 1
41 25801233 Changes in the response of MCF-7 cells to ionizing radiation after the combination of ATM and DNA-PK inhibition. 2015 May 1
42 24370835 Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis. 2014 Feb 3 1
43 24464432 Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors. 2014 Apr 2
44 24480460 Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair networks. 2014 May 2
45 24568192 cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells. 2014 Feb 24 1
46 24622963 DNA double-strand break repair and induction of apoptosis in ex vivo irradiated blood lymphocytes in relation to late normal tissue reactions following breast radiotherapy. 2014 May 2
47 24821553 Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-1α transactivation. 2014 Jul 3
48 24841718 Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. 2014 1
49 24966912 Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase. 2014 1
50 25486524 DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation. 2014 Dec 8 2