| 1 |
34485929 | Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. | 2021 |
3 |
| 2 |
27439492 | Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II. | 2016 Oct |
1 |
| 3 |
25528333 | Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase. | 2015 Jan 27 |
2 |
| 4 |
25785110 | Associations between human aldosterone synthase CYP11B2 (-344T/C) gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension. | 2015 |
1 |
| 5 |
24959941 | Development of a high-throughput assay for aldosterone synthase inhibitors using high-performance liquid chromatography-tandem mass spectrometry. | 2014 Oct 1 |
1 |
| 6 |
23045428 | Aldosterone synthase inhibition in humans. | 2013 Jan |
1 |
| 7 |
23322723 | Structural insights into aldosterone synthase substrate specificity and targeted inhibition. | 2013 Feb |
2 |
| 8 |
22446688 | Human aldosterone synthase: recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level. | 2012 Oct |
3 |
| 9 |
21598279 | Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation. | 2011 Aug |
1 |
| 10 |
20494601 | Five novel mutations in CYP11B2 gene detected in patients with aldosterone synthase deficiency type I: Functional characterization and structural analyses. | 2010 Aug |
1 |
| 11 |
19622340 | Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. | 2009 Nov 1 |
1 |
| 12 |
18292466 | A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. | 2008 Apr |
2 |
| 13 |
15134803 | The regulation of aldosterone synthase expression. | 2004 Mar 31 |
1 |
| 14 |
11856349 | The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme. | 2002 Feb |
1 |
| 15 |
11549669 | Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase. | 2001 Sep |
1 |
| 16 |
10720073 | Amino acid residue 147 of human aldosterone synthase and 11beta-hydroxylase plays a key role in 11beta-hydroxylation. | 2000 Mar |
3 |
| 17 |
10559665 | Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies. | 1999 |
1 |
| 18 |
9809191 | Structure-function relationships of aldosterone synthase and 11 beta-hydroxylase enzymes: implications for human hypertension. | 1998 Nov |
3 |
| 19 |
9814482 | Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. | 1998 Nov |
1 |
| 20 |
9003023 | Ca(2+)-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases. | 1997 Feb |
2 |
| 21 |
9139807 | Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements. | 1997 May |
1 |
| 22 |
8768832 | Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin. | 1996 Aug |
1 |
| 23 |
7852500 | Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency. | 1995 Feb |
2 |
| 24 |
1775135 | The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. | 1991 Oct |
1 |
| 25 |
2256920 | Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism. | 1990 Nov 30 |
1 |