Desoxycorticosterone

cytochrome P450 family 11 subfamily B member 2 ; Homo sapiens







25 Article(s)
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Pub. Year
#Total Relationships
1 34485929 Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis. 2021 3
2 27439492 Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II. 2016 Oct 1
3 25528333 Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase. 2015 Jan 27 2
4 25785110 Associations between human aldosterone synthase CYP11B2 (-344T/C) gene polymorphism and antihypertensive response to valsartan in Chinese patients with essential hypertension. 2015 1
5 24959941 Development of a high-throughput assay for aldosterone synthase inhibitors using high-performance liquid chromatography-tandem mass spectrometry. 2014 Oct 1 1
6 23045428 Aldosterone synthase inhibition in humans. 2013 Jan 1
7 23322723 Structural insights into aldosterone synthase substrate specificity and targeted inhibition. 2013 Feb 2
8 22446688 Human aldosterone synthase: recombinant expression in E. coli and purification enables a detailed biochemical analysis of the protein on the molecular level. 2012 Oct 3
9 21598279 Application of a ligand-based theoretical approach to derive conversion paths and ligand conformations in CYP11B2-mediated aldosterone formation. 2011 Aug 1
10 20494601 Five novel mutations in CYP11B2 gene detected in patients with aldosterone synthase deficiency type I: Functional characterization and structural analyses. 2010 Aug 1
11 19622340 Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors. 2009 Nov 1 1
12 18292466 A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function. 2008 Apr 2
13 15134803 The regulation of aldosterone synthase expression. 2004 Mar 31 1
14 11856349 The effect of amino-acid substitutions I112P, D147E and K152N in CYP11B2 on the catalytic activities of the enzyme. 2002 Feb 1
15 11549669 Effects of 18-hydroxylated steroids on corticosteroid production by human aldosterone synthase and 11beta-hydroxylase. 2001 Sep 1
16 10720073 Amino acid residue 147 of human aldosterone synthase and 11beta-hydroxylase plays a key role in 11beta-hydroxylation. 2000 Mar 3
17 10559665 Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies. 1999 1
18 9809191 Structure-function relationships of aldosterone synthase and 11 beta-hydroxylase enzymes: implications for human hypertension. 1998 Nov 3
19 9814482 Recombinant CYP11B genes encode enzymes that can catalyze conversion of 11-deoxycortisol to cortisol, 18-hydroxycortisol, and 18-oxocortisol. 1998 Nov 1
20 9003023 Ca(2+)-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases. 1997 Feb 2
21 9139807 Angiotensin II and potassium regulate human CYP11B2 transcription through common cis-elements. 1997 May 1
22 8768832 Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin. 1996 Aug 1
23 7852500 Amino acid substitution R384P in aldosterone synthase causes corticosterone methyloxidase type I deficiency. 1995 Feb 2
24 1775135 The product of the CYP11B2 gene is required for aldosterone biosynthesis in the human adrenal cortex. 1991 Oct 1
25 2256920 Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism. 1990 Nov 30 1