S-Adenosylmethionine

⇄

methylenetetrahydrofolate reductase ; Homo sapiens







40 Article(s)
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1 33476699 Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain. 2021 Apr 4
2 31968288 Mutational landscape screening of methylene tetrahydrofolate reductase to predict homocystinuria associated variants: An integrative computational approach. 2020 Jan - Apr 2
3 32334045 Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype. 2020 Jun 4
4 33168819 MiR-22, regulated by MeCP2, suppresses gastric cancer cell proliferation by inducing a deficiency in endogenous S-adenosylmethionine. 2020 Nov 10 1
5 30606816 MTHFR C677T polymorphism increases MTX sensitivity via the inhibition of S-adenosylmethionine and de novo purine synthesis. 2019 Jan 31 1
6 30646578 Epigenetic Factors in Late-Onset Alzheimer's Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Transsulfuration and Methylation Pathways, and B Vitamins. 2019 Jan 14 2
7 30862944 Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase. 2019 Mar 12 2
8 29891918 Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition. 2018 Jun 11 1
9 27707701 Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. 2016 Nov 2
10 25887881 The active site of oxidative phosphorylation and the origin of hyperhomocysteinemia in aging and dementia. 2015 Spring 1
11 24286468 The maize brown midrib2 (bm2) gene encodes a methylenetetrahydrofolate reductase that contributes to lignin accumulation. 2014 Feb 1
12 24412677 Genetic variants of homocysteine metabolism and multiple sclerosis: a case-control study. 2014 Mar 6 2
13 24101362 Effects of methionine synthase and methylenetetrahydrofolate reductase gene polymorphisms on markers of one-carbon metabolism. 2013 Nov 4
14 24385849 The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells. 2013 Dec 4
15 21304959 Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. 2011 Jan 31 4
16 21858212 Properties and crystal structure of methylenetetrahydrofolate reductase from Thermus thermophilus HB8. 2011 1
17 20444942 Strain-specific defects in testicular development and sperm epigenetic patterns in 5,10-methylenetetrahydrofolate reductase-deficient mice. 2010 Jul 2
18 19082889 MTHFR 677T carrier influences the methylation status of H. pylori-infected gastric mucosa in older subjects. 2009 Nov 1
19 21475826 Effect of the methylenetetrahydrofolate reductase gene C677T polymorphism on C-erbB-2 methylation status and its association with cancer. 2009 Mar-Apr 2
20 18317335 C677T methylene-H4-folate-reductase variant decreases binocular accommodation. 2008 Mar 4
21 17301815 Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts. 2007 Apr 1
22 17457696 Intermediate hyperhomocysteinaemia and compound heterozygosity for the common variant c.677C>T and a MTHFR gene mutation. 2007 Jun 2
23 16988141 A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. 2006 Oct 3
24 15548731 Infertility in 5,10-methylenetetrahydrofolate reductase (MTHFR)-deficient male mice is partially alleviated by lifetime dietary betaine supplementation. 2005 Mar 2
25 15973722 Pharmacogenetic association with adverse drug reactions to azathioprine immunosuppressive therapy following liver transplantation. 2005 Jul 2
26 16024724 Regulation of human methylenetetrahydrofolate reductase by phosphorylation. 2005 Jul 26 2
27 16047261 Homocysteine: overview of biochemistry, molecular biology, and role in disease processes. 2005 May 1
28 12801808 [Hyperhomocysteinemia: an independent risk factor or a simple marker of vascular disease?. 1. Basic data]. 2003 Mar 2
29 11929966 A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. 2002 Apr 16 2
30 11406421 Polymorphic methyl group metabolism genes in patients with transitional cell carcinoma of the urinary bladder. 2001 Jun 4
31 11742092 Effects of common polymorphisms on the properties of recombinant human methylenetetrahydrofolate reductase. 2001 Dec 18 1
32 10952104 Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. 2000 Aug 2
33 11074524 Methyl group metabolism gene polymorphisms and susceptibility to prostatic carcinoma. 2000 Nov 1 2
34 11508552 Hydrocephalus internus in two patients with 5,10-methylenetetrahydrofolate reductase deficiency. 2000 Dec 2
35 10448523 Homocysteine metabolism. 1999 1
36 10593891 Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants. 1999 Dec 17 1
37 3818603 Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium. 1987 Feb 25 1
38 3754872 Photoaffinity labeling of methylenetetrahydrofolate reductase with 8-azido-S-adenosylmethionine. 1986 Jun 15 2
39 3927946 Vitamin B12-folate interrelationships. 1985 1
40 7051769 Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues. 1982 3