Folic Acid

folylpolyglutamate synthase ; Homo sapiens







79 Article(s)
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51 9291820 Relevance of tumoral folylpolyglutamate synthetase and reduced folates for optimal 5-fluorouracil efficacy: experimental data. 1997 May 1
52 9479873 Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance. 1997 Dec 1
53 9815719 Decreased folylpolyglutamate synthetase activity in tumors resistant to fluorouracil-folinic acid treatment: clinical data. 1997 Apr 2
54 8662720 Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene. 1996 May 31 3
55 8740793 Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy. 1996 Mar 2
56 8764125 In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase. 1996 Jul 15 2
57 8869756 The role of dietary folate in modulation of folate receptor expression, folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol. 1996 1
58 8958187 Exploitation of folate and antifolate polyglutamylation to achieve selective anticancer chemotherapy. 1996 2
59 7721888 Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. 1995 Apr 21 3
60 7890662 Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation. 1995 Mar 10 1
61 8521387 Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus. 1995 Dec 15 1
62 7517720 Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. 1994 Jul 15 4
63 8114682 A strategy for the design of membrane-permeable folypoly-gamma-glutamate synthetase inhibitors: "bay-region"-substituted 2-desamino-2-methyl-5,8-dideazafolate analogs. 1994 Feb 6
64 8408018 Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity. 1993 Oct 15 8
65 8408019 Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism. 1993 Oct 15 5
66 1435744 Determinants of antifolate cytotoxicity: folylpolyglutamate synthetase activity during cellular proliferation and development. 1992 Oct 3
67 2007575 Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. 1991 Apr 5 2
68 2168155 Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate. 1990 Sep 2
69 2906805 Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates. 1988 Dec 13 1
70 3190739 Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs. 1988 Oct 15 4
71 2448651 Structural requirements for the activity of antifolates as substrates for mammalian folylpolyglutamate synthetase. 1987 1
72 2448652 Folate analog nonsubstrates and inhibitors of folylpolyglutamate synthetase as potential cancer chemotherapy drugs. 1987 1
73 3619447 Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists. 1987 Aug 1 3
74 3807889 Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs. 1987 Jan 4
75 3466358 Characterization of human folylpolyglutamate synthetase expressed in Chinese hamster ovary cells. 1986 Nov 1
76 3756000 Biosynthesis of polyglutamates of folates. 1986 Jul 2
77 3812977 In situ autoradiographic detection of folylpolyglutamate synthetase activity. 1986 Nov 1 3
78 3873989 Folate analogues as substrates of mammalian folylpolyglutamate synthetase. 1985 Jul 1
79 6577780 Characterization of the function of mammalian folylpolyglutamate synthetase (FPGS). 1983 2