| 1 |
33676037 | Folylpoly-ɣ-glutamate synthetase association to the cytoskeleton: Implications to folate metabolon compartmentalization. | 2021 May 15 |
10 |
| 2 |
34289180 | Maternal genotypes of folate/one-carbon metabolism gene variants and nonsyndromic cleft lip with or without cleft palate risk in Chile. | 2021 Oct |
1 |
| 3 |
31754833 | High gamma-glutamyl hydrolase and low folylpolyglutamate synthetase expression as prognostic biomarkers in patients with locally advanced gastric cancer who were administrated postoperative adjuvant chemotherapy with S-1. | 2020 Jan |
2 |
| 4 |
32256983 | Enzymes involved in folate metabolism and its implication for cancer treatment. | 2020 Apr |
7 |
| 5 |
33164984 | Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo. | 2020 Dec 1 |
1 |
| 6 |
31008996 | Development and Validation of a Sensitive UHPLC-MS/MS-Based Method for the Analysis of Folylpolyglutamate Synthetase Enzymatic Activity in Peripheral Blood Mononuclear Cells: Application in Rheumatoid Arthritis and Leukemia Patients. | 2019 Oct |
4 |
| 7 |
31585510 | Elimination of human folypolyglutamate synthetase alters programming and plasticity of somatic cells. | 2019 Dec |
2 |
| 8 |
26895662 | Effects of folylpolyglutamate synthase modulation on global and gene-specific DNA methylation and gene expression in human colon and breast cancer cells. | 2016 Mar |
4 |
| 9 |
27620954 | Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer. | 2016 Sep |
8 |
| 10 |
26107232 | Mutation Screening and Association Study of the Folylpolyglutamate Synthetase (FPGS) Gene with Susceptibility to Childhood Acute Lymphoblastic Leukemia. | 2015 |
4 |
| 11 |
24447348 | Folic acid pathway single nucleotide polymorphisms associated with methotrexate significant adverse events in United States veterans with rheumatoid arthritis. | 2014 May-Jun |
2 |
| 12 |
25164808 | Mammalian mitochondrial and cytosolic folylpolyglutamate synthetase maintain the subcellular compartmentalization of folates. | 2014 Oct 17 |
1 |
| 13 |
24168269 | FPGS rs1544105 polymorphism is associated with treatment outcome in pediatric B-cell precursor acute lymphoblastic leukemia. | 2013 Oct 29 |
2 |
| 14 |
22018726 | Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study. | 2012 Jan |
4 |
| 15 |
21093159 | FPGS gene is a novel causative gene for cleft lip in China. | 2011 Mar |
7 |
| 16 |
21380490 | In vivo evidence for a significant role of folylpolyglutamate synthase in combined chemotherapy with oral fluoropyrimidine, UFT or S-1, and leucovorin. | 2011 May |
4 |
| 17 |
19636555 | Molecular determinants of folate levels after leucovorin administration in colorectal cancer. | 2010 Mar |
1 |
| 18 |
20020129 | Cellular and molecular mechanisms for the synergistic cytotoxicity elicited by oxaliplatin and pemetrexed in colon cancer cell lines. | 2010 Aug |
1 |
| 19 |
20350571 | Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition. | 2010 Jul |
2 |
| 20 |
19131550 | Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia. | 2009 Apr 30 |
2 |
| 21 |
20025500 | A monoclonal antibody for detection of folylpolyglutamate synthetase in paraffin embedded tissues. | 2009 Dec |
5 |
| 22 |
18035049 | Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity. | 2008 Jan 25 |
2 |
| 23 |
18418463 | p16INK4a gene promoter hypermethylation in mucosa as a prognostic factor for patients with colorectal cancer. | 2008 Jul-Aug |
2 |
| 24 |
18672898 | Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. | 2008 Aug 26 |
2 |
| 25 |
18804701 | Mechanism-based inhibitors of folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase: control of folylpoly-gamma-glutamate homeostasis as a drug target. | 2008 |
1 |
| 26 |
18842806 | Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. | 2008 Oct |
1 |
| 27 |
16884772 | Molecular basis for decreased folylpoly-gamma-glutamate synthetase expression in a methotrexate resistant CCRF-CEM mutant cell line. | 2007 Mar |
1 |
| 28 |
17333344 | Molecular basis of antifolate resistance. | 2007 Mar |
2 |
| 29 |
17600497 | Derivation and characterization of monoclonal antibodies against human folypolyglutamate synthetase. | 2007 Jun |
2 |
| 30 |
17896913 | Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I. | 2007 Sep |
1 |
| 31 |
18025275 | Effects of folate and folylpolyglutamyl synthase modulation on chemosensitivity of breast cancer cells. | 2007 Nov |
10 |
| 32 |
16686541 | Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. | 2006 May 18 |
1 |
| 33 |
15705579 | Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy. | 2005 May 13 |
2 |
| 34 |
15542523 | Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate. | 2004 Dec |
5 |
| 35 |
12527324 | Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate. | 2003 Feb 1 |
2 |
| 36 |
14676127 | Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. | 2003 Dec 1 |
4 |
| 37 |
12678736 | Recent advances in the chemistry and biology of folypoly-gamma-glutamate synthetase substrates and inhibitors. | 2002 May |
1 |
| 38 |
11223131 | A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. | 2001 Feb |
2 |
| 39 |
11509884 | Murine cytomegalovirus infection induces cellular folylpolyglutamate synthetase activity in quiescent cells. | 2001 |
3 |
| 40 |
10648167 | Purification and characteristics of recombinant human folylpoly-gamma-glutamate synthetase expressed at high levels in insect cells. | 2000 Feb |
1 |
| 41 |
10964921 | Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues. | 2000 Nov 17 |
2 |
| 42 |
9952321 | Folic acid-enhanced synergy for the combination of trimetrexate plus the glycinamide ribonucleotide formyltransferase inhibitor 4-[2-(2-amino-4-oxo-4,6,7,8-tetrahydro-3H-pyrimidino[5,4,6][1,4]thiazin -6-yl)-(S)-ethyl]-2,5-thienoylamino-L-glutamic acid (AG2034): comparison across sensitive and resistant human tumor cell lines. | 1999 Mar 1 |
3 |
| 43 |
10470377 | Folylpoly-gamma-glutamate synthetase: generation of isozymes and the role in one carbon metabolism and antifolate cytotoxicity. | 1999 |
2 |
| 44 |
10507318 | Variable expression of the folylpolyglutamate synthetase gene at the level of mRNA transcription in human leukemia cell lines sensitive, or made resistant, to various antifolate drugs. | 1999 Aug |
1 |
| 45 |
10598551 | Roles of folylpoly-gamma-glutamate synthetase in therapeutics with tetrahydrofolate antimetabolites: an overview. | 1999 Apr |
7 |
| 46 |
10626793 | Tissue-specific expression of functional isoforms of mouse folypoly-gamma-glutamae synthetase: a basis for targeting folate antimetabolites. | 1999 Dec 15 |
4 |
| 47 |
9647673 | Mechanism-based inhibition of human folylpolyglutamate synthetase: design, synthesis, and biochemical characterization of a phosphapeptide mimic of the tetrahedral intermediate. | 1998 Jul 1 |
2 |
| 48 |
9679969 | Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation. | 1998 Jul 15 |
1 |
| 49 |
9714324 | Effects of antisense-based folypoly-gamma-glutamate synthetase down-regulation on reduced folates and cellular proliferation in CCRF-CEM cells. | 1998 Jun 15 |
4 |
| 50 |
9147608 | Folate-based thymidylate synthase inhibitors in cancer chemotherapy. | 1997 Jan |
6 |