| 1 |
33538594 | Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6. | 2021 Mar 15 |
3 |
| 2 |
33831382 | Effects of memantine and its metabolite Mrz 2/373 on soman-induced inhibition of acetylcholinesterase in vitro. | 2021 Jun 1 |
1 |
| 3 |
32175496 | Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates. | 2020 Mar 10 |
2 |
| 4 |
32267631 | A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma. | 2020 Jul |
2 |
| 5 |
30763608 | Human small bowel as model for poisoning with organophosphorus compounds. | 2019 Jun |
1 |
| 6 |
30858091 | The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). | 2019 Jun 15 |
1 |
| 7 |
28446076 | Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach. | 2018 May |
3 |
| 8 |
28993240 | The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study. | 2018 Sep 1 |
1 |
| 9 |
29019446 | The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study. | 2018 Oct |
1 |
| 10 |
29735900 | Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. | 2018 May 7 |
1 |
| 11 |
29773682 | Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase. | 2018 Jun 29 |
2 |
| 12 |
30312685 | Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro. | 2018 Dec 15 |
1 |
| 13 |
30462502 | Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI-6. | 2018 Dec 17 |
2 |
| 14 |
27358236 | Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6. | 2017 Mar |
1 |
| 15 |
27153754 | Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. | 2016 Mar 28 |
3 |
| 16 |
27179675 | A liquid chromatography tandem mass spectrometric method on in vitro nerve agents poisoning characterization and reactivator efficacy evaluation by determination of specific peptide adducts in acetylcholinesterase. | 2016 Jun 10 |
1 |
| 17 |
27191504 | Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. | 2016 Sep |
1 |
| 18 |
26468911 | Protein-Drug Interactions with Effective Polarization in Polarizable Water: Oxime Unbinding from AChE Gorge. | 2015 Nov 12 |
1 |
| 19 |
25240274 | Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. | 2014 Nov 18 |
2 |
| 20 |
22982773 | A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. | 2013 Mar 25 |
2 |
| 21 |
23111374 | Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents. | 2013 Mar 25 |
1 |
| 22 |
23376121 | Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity. | 2013 May 1 |
6 |
| 23 |
23917882 | Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. | 2013 Aug 2 |
1 |
| 24 |
23936743 | Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. | 2013 Aug |
1 |
| 25 |
22360473 | Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. | 2012 May 15 |
1 |
| 26 |
22447833 | Cytotoxicity and genotoxicity evaluation of antidote oxime HI-6 tested on eight cell lines of human and rodent origin. | 2012 Mar |
1 |
| 27 |
23030612 | Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data. | 2012 |
1 |
| 28 |
20027669 | Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides. | 2011 Jul |
2 |
| 29 |
21451868 | First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase. | 2011 May 14 |
1 |
| 30 |
21673941 | In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. | 2011 |
2 |
| 31 |
21730071 | Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. | 2011 Aug 26 |
1 |
| 32 |
21803135 | Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6. | 2011 Sep 25 |
1 |
| 33 |
20417629 | Interactions of pyridinium oximes with acetylcholinesterase. | 2010 Sep 6 |
2 |
| 34 |
20655881 | Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes. | 2010 Nov 1 |
1 |
| 35 |
20888357 | Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach. | 2010 Dec 15 |
1 |
| 36 |
19356117 | Study of efficacy of reactivator HI 6 in reactivation of immobilized acetylcholinesterase, inhibited by organophosphorus chemical warfare agents of the "G" series. | 2009 Jan |
1 |
| 37 |
19429253 | Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study. | 2009 Jun 1 |
1 |
| 38 |
19519385 | Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. | 2009 |
1 |
| 39 |
19651196 | Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. | 2009 Oct 28 |
1 |
| 40 |
19663821 | Irinotecan side effects relieved by the use of HI-6 oxime: in vivo experimental approach. | 2009 Dec |
2 |
| 41 |
19761810 | Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis. | 2009 Nov 30 |
1 |
| 42 |
18804659 | Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. | 2008 Oct 19 |
1 |
| 43 |
20020898 | In Vitro Comparison of Two Most Promising H-Oximes (HI-6 and HLö-7) and Currently Commercially Available Reactivators Pralidoxime and Obidoxime in Reactivation of Cyclosarin-Inhibited Human Cholinesterases. | 2008 |
1 |
| 44 |
17370251 | Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. | 2007 Nov-Dec |
2 |
| 45 |
17713603 | Evaluation of HI-6 oxime: potential use in protection of human acetylcholinesterase inhibited by antineoplastic drug irinotecan and its cyto/genotoxicity in vitro. | 2007 |
1 |
| 46 |
17900152 | An in vitro comparative study on the reactivation of nerve agent-inhibited guinea pig and human acetylcholinesterases by oximes. | 2007 Oct 23 |
1 |
| 47 |
17913691 | Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds. | 2007 Sep |
1 |
| 48 |
18254274 | Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). | 2007 |
3 |
| 49 |
16740352 | Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning. | 2006 Jul 5 |
1 |
| 50 |
17252938 | Potency of new structurally different oximes to reactivate cyclosarin-inhibited human brain acetylcholinesterases. | 2006 Dec |
1 |