| 1 |
35526478 | Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. | 2022 Aug 5 |
1 |
| 2 |
32305437 | Structural and kinetic evidence of aging after organophosphate inhibition of human Cathepsin A. | 2020 Jul |
1 |
| 3 |
32454005 | Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase. | 2020 Aug 1 |
1 |
| 4 |
32583098 | Targeting organophosphorus compounds poisoning by novel quinuclidine-3 oximes: development of butyrylcholinesterase-based bioscavengers. | 2020 Sep |
1 |
| 5 |
30858091 | The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). | 2019 Jun 15 |
1 |
| 6 |
30096649 | Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase. | 2018 Sep 5 |
2 |
| 7 |
30312685 | Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro. | 2018 Dec 15 |
1 |
| 8 |
30383374 | Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents. | 2018 Dec 13 |
1 |
| 9 |
26210933 | Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. | 2016 Feb 26 |
1 |
| 10 |
27238725 | Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases. | 2016 Nov 25 |
1 |
| 11 |
25522658 | Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. | 2015 Feb 3 |
1 |
| 12 |
24443939 | Exploring the physicochemical properties of oxime-reactivation therapeutics for cyclosarin, sarin, tabun, and VX inactivated acetylcholinesterase. | 2014 Jan 21 |
2 |
| 13 |
24630558 | Design, synthesis, and characterization of novel, nonquaternary reactivators of GF-inhibited human acetylcholinesterase. | 2014 Apr 1 |
2 |
| 14 |
22975155 | Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates. | 2013 Mar 25 |
1 |
| 15 |
22982773 | A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. | 2013 Mar 25 |
2 |
| 16 |
23376121 | Catalytic-site conformational equilibrium in nerve-agent adducts of acetylcholinesterase: possible implications for the HI-6 antidote substrate specificity. | 2013 May 1 |
2 |
| 17 |
23789829 | In silico pharmacophore modeling on known pyridinium oxime reactivators of cyclosarin (GF) inhibited AChE to Aid discovery of potential, more efficacious novel non-oxime reactivators. | 2013 Sep |
2 |
| 18 |
22343626 | Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. | 2012 Apr 6 |
1 |
| 19 |
22520752 | Evolved stereoselective hydrolases for broad-spectrum G-type nerve agent detoxification. | 2012 Apr 20 |
1 |
| 20 |
22561105 | Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase. | 2012 Jul 7 |
1 |
| 21 |
21217689 | Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. | 2011 Feb |
1 |
| 22 |
21930118 | Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. | 2011 Nov 15 |
1 |
| 23 |
22238531 | Highly efficient cyclosarin degradation mediated by a β-cyclodextrin derivative containing an oxime-derived substituent. | 2011 |
1 |
| 24 |
20192902 | Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase. | 2010 Aug |
1 |
| 25 |
20510679 | Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds. | 2010 Sep 15 |
3 |
| 26 |
20888357 | Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach. | 2010 Dec 15 |
1 |
| 27 |
18565503 | Reactivation of DFP- and paraoxon-inhibited acetylcholinesterases by pyridinium oximes. | 2008 Sep 25 |
2 |
| 28 |
18588863 | Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity. | 2008 Sep 25 |
1 |
| 29 |
20020898 | In Vitro Comparison of Two Most Promising H-Oximes (HI-6 and HLö-7) and Currently Commercially Available Reactivators Pralidoxime and Obidoxime in Reactivation of Cyclosarin-Inhibited Human Cholinesterases. | 2008 |
1 |
| 30 |
17112559 | Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis. | 2007 Mar |
1 |
| 31 |
17370251 | Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. | 2007 Nov-Dec |
1 |
| 32 |
17503257 | Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin. | 2007 Jun-Aug |
2 |
| 33 |
17960099 | Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator. | 2007 Aug 20 |
2 |
| 34 |
18045198 | Structural factors influencing potency of currently used acetylcholinesterase reactivators for treatment of cyclosarin intoxications. | 2007 |
3 |
| 35 |
17194020 | New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin. | 2006 Oct |
5 |
| 36 |
17438836 | Reactivation potency of new group of acetylcholinesterase reactivators and their comparison with currently available oximes. | 2006 |
3 |
| 37 |
15911280 | Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents. | 2005 Jun 2 |
1 |
| 38 |
16429489 | Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivo. | 2005 Dec 15 |
1 |
| 39 |
14985944 | Effect of organophosphorus hydrolysing enzymes on obidoxime-induced reactivation of organophosphate-inhibited human acetylcholinesterase. | 2004 Jun |
1 |
| 40 |
15544060 | A comparison of the efficacy of a bispyridinium oxime--1,4-bis-(2-hydroxyiminomethylpyridinium) butane dibromide and currently used oximes to reactivate sarin, tabun or cyclosarin-inhibited acetylcholinesterase by in vitro methods. | 2004 Oct |
1 |
| 41 |
15568733 | 1,3-Bis(2-hydroxyiminomethylpyridinium) propane as the potential reactivator of the acetylcholinesterase inhibited by nerve agents. | 2004 |
2 |
| 42 |
12373455 | Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate. | 2002 Oct |
1 |
| 43 |
9587020 | Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. | 1998 Mar |
2 |
| 44 |
9806430 | Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterases. | 1998 Sep |
1 |