1-benzylpiperidine

acetylcholinesterase (Cartwright blood group) ; Homo sapiens







20 Article(s)
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Title
Pub. Year
#Total Relationships
1 35462163 Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease. 2022 Jul 5 1
2 34327619 Machine learning models for predicting the activity of AChE and BACE1 dual inhibitors for the treatment of Alzheimer's disease. 2021 Jul 29 2
3 31901380 Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene. 2020 Feb 15 1
4 30784883 Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease. 2019 Apr 1 2
5 31585263 Design, synthesis and biological evaluation of novel copper-chelating acetylcholinesterase inhibitors with pyridine and N-benzylpiperidine fragments. 2019 Dec 1
6 29421570 Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates. 2018 Mar 10 2
7 27914796 Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors. 2017 Jan 15 2
8 28610432 QSAR model for prediction of the therapeutic potency of N-benzylpiperidine derivatives as AChE inhibitors. 2017 Jun 4
9 28841514 A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease. 2017 Oct 20 1
10 27402296 New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition. 2016 Jul 2
11 24211638 Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. 2013 3
12 21074294 Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE). 2011 Jan 2
13 15892689 Human acetylcholinesterase inhibitors: electronic-topological and neural network approaches to the structure-activity relationships study. 2005 May 2
14 10733609 Validation of protein-based alignment in 3D quantitative structure-activity relationships with CoMFA models. 2000 Jan 2
15 11256231 Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. 2000 Oct 1
16 10067428 [Discovery and development of donepezil hydrochloride for the treatment of Alzheimer's disease]. 1999 Feb 1
17 8558505 A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. 1996 Jan 19 1
18 8894101 The rationale for E2020 as a potent acetylcholinesterase inhibitor. 1996 Sep 1
19 1738151 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. 1992 Feb 7 3
20 1738152 Conformational analyses and molecular-shape comparisons of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. 1992 Feb 7 1