| 1 |
33047663 | Molecular recognition of acetylcholinesterase and its subnanomolar reversible inhibitor: a molecular simulations study. | 2022 Mar |
2 |
| 2 |
34165688 | New benzamide derivatives and their nicotinamide/cinnamamide analogs as cholinesterase inhibitors. | 2022 Apr |
1 |
| 3 |
34801945 | Design, Synthesis, biological investigations and molecular interactions of triazole linked tacrine glycoconjugates as Acetylcholinesterase inhibitors with reduced hepatotoxicity. | 2022 Jan |
4 |
| 4 |
35098414 | Alzheimer's disease therapy based on acetylcholinesterase inhibitor/blocker effects on voltage-gated potassium channels. | 2022 Mar |
2 |
| 5 |
35225413 | Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α-glycosidase. | 2022 Apr |
2 |
| 6 |
35526766 | Crystal structure of human acetylcholinesterase in complex with tacrine: Implications for drug discovery. | 2022 Jun 15 |
6 |
| 7 |
33076048 | A thiamine-triggered fluormetric assay for acetylcholinesterase activity and inhibitor screening based on oxidase-like activity of MnO2 nanosheets. | 2021 Jan 1 |
2 |
| 8 |
33189440 | ROS-responsive and multifunctional anti-Alzheimer prodrugs: Tacrine-ibuprofen hybrids via a phenyl boronate linker. | 2021 Feb 15 |
2 |
| 9 |
33338868 | Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer's disease. | 2021 Feb 5 |
2 |
| 10 |
33421953 | Tacrine - Benzothiazoles: Novel class of potential multitarget anti-Alzheimeŕs drugs dealing with cholinergic, amyloid and mitochondrial systems. | 2021 Feb |
2 |
| 11 |
33540879 | Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer's Disease. | 2021 Feb 2 |
1 |
| 12 |
33583371 | Multi-Target Drug Design of Anti-Alzheimer's Disease based on Tacrine. | 2021 |
5 |
| 13 |
33645607 | Tacrine-sugar mimetic conjugates as enhanced cholinesterase inhibitors. | 2021 Mar 18 |
1 |
| 14 |
33839958 | Colorimetric detection of acetylcholinesterase and its inhibitor based on thiol-regulated oxidase-like activity of 2D palladium square nanoplates on reduced graphene oxide. | 2021 Apr 10 |
3 |
| 15 |
33844597 | Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition. | 2021 Apr |
1 |
| 16 |
33930191 | Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget. | 2021 Sep |
1 |
| 17 |
33979725 | Binding studies of known molecules with acetylcholinesterase and bovine serum albumin: A comparative view. | 2021 Oct 5 |
2 |
| 18 |
34024109 | Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease. | 2021 Jun 10 |
1 |
| 19 |
34156230 | Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease. | 2021 Jul 7 |
3 |
| 20 |
34294013 | Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase. | 2021 Dec |
2 |
| 21 |
34385868 | Novel Mannich bases with strong carbonic anhydrases and acetylcholinesterase inhibition effects: 3-(aminomethyl)-6-{3-[4-(trifluoromethyl)phenyl]acryloyl}-2(3H)-benzoxazolones. | 2021 |
2 |
| 22 |
34443482 | Synthesis, Biological Evaluation, and In Silico Studies of New Acetylcholinesterase Inhibitors Based on Quinoxaline Scaffold. | 2021 Aug 12 |
1 |
| 23 |
34531295 | Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. | 2021 Nov |
6 |
| 24 |
34880083 | Correction to "Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells". | 2021 Dec |
1 |
| 25 |
31357051 | Colorimetric assay of acetylcholinesterase inhibitor tacrine based on MoO2 nanoparticles as peroxidase mimetics. | 2020 Jan 5 |
3 |
| 26 |
31978679 | Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease. | 2020 Mar |
1 |
| 27 |
31996889 | Switching enzyme activity by a temperature responsive inhibitor modified polymer. | 2020 Feb 25 |
1 |
| 28 |
32032848 | Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors. | 2020 Mar |
4 |
| 29 |
32825138 | Merged Tacrine-Based, Multitarget-Directed Acetylcholinesterase Inhibitors 2015-Present: Synthesis and Biological Activity. | 2020 Aug 19 |
4 |
| 30 |
32986667 | Novel Hybrid Acetylcholinesterase Inhibitors Induce Differentiation and Neuritogenesis in Neuronal Cells in vitro Through Activation of the AKT Pathway. | 2020 |
1 |
| 31 |
33383645 | Model Amphipathic Peptide Coupled with Tacrine to Improve Its Antiproliferative Activity. | 2020 Dec 29 |
1 |
| 32 |
33488178 | Combined ligand and structure-based virtual screening approaches for identification of novel AChE inhibitors. | 2020 |
1 |
| 33 |
30798053 | Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. | 2019 Apr 15 |
1 |
| 34 |
30849722 | A ratiometric fluorescence probe based on carbon dots for discriminative and highly sensitive detection of acetylcholinesterase and butyrylcholinesterase in human whole blood. | 2019 Apr 15 |
1 |
| 35 |
30851693 | Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. | 2019 Apr 15 |
1 |
| 36 |
31059278 | Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics. | 2019 Jun 3 |
1 |
| 37 |
31125474 | Synthesis of 2-(2-oxo-2H-chromen-4-yl)acetamides as potent acetylcholinesterase inhibitors and molecular insights into binding interactions. | 2019 Jul |
1 |
| 38 |
31158577 | Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives. | 2019 Aug |
2 |
| 39 |
31170562 | Alignment-independent 3D-QSAR and molecular docking studies of tacrine-4-oxo-4H-Chromene hybrids as anti-Alzheimer's agents. | 2019 Jun |
2 |
| 40 |
31228470 | The in vitro protective effects of the three novel nanomolar reversible inhibitors of human cholinesterases against irreversible inhibition by organophosphorous chemical warfare agents. | 2019 Aug 25 |
1 |
| 41 |
31281020 | Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids. | 2019 Aug 15 |
2 |
| 42 |
31556693 | Tacroximes: novel unique compounds for the recovery of organophosphorus-inhibited acetylcholinesterase. | 2019 Oct |
1 |
| 43 |
28792233 | Synthesis of chalcone-imide derivatives and investigation of their anticancer and antimicrobial activities, carbonic anhydrase and acetylcholinesterase enzymes inhibition profiles. | 2018 Feb |
1 |
| 44 |
29149534 | Novel N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts: Synthesis, characterization, and determination of their metal chelating effects and inhibition profiles against acetylcholinesterase and carbonic anhydrase enzymes. | 2018 Jan |
1 |
| 45 |
29390887 | Prediction of therapeutic potency of tacrine derivatives as BuChE inhibitors from quantitative structure-activity relationship modelling. | 2018 Mar |
1 |
| 46 |
29533874 | The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease. | 2018 Apr 25 |
3 |
| 47 |
29567174 | Protein-mimicking nanowire-inspired electro-catalytic biosensor for probing acetylcholinesterase activity and its inhibitors. | 2018 Jun 1 |
1 |
| 48 |
29635172 | Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening. | 2018 Jun 5 |
1 |
| 49 |
29870588 | New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease. | 2018 Jul |
2 |
| 50 |
29992880 | Tacrine-coumarin and Tacrine-7-chloroquinoline Hybrids with Thiourea Linkers: Cholinesterase Inhibition Properties, Kinetic Study, Molecular Docking and Permeability Assay for Blood-brain Barrier. | 2018 |
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