coumarin

acetylcholinesterase (Cartwright blood group) ; Homo sapiens







34 Article(s)
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1 34558680 Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation. 2022 Mar 1
2 35195417 Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies. 2022 Mar 10 1
3 35300078 Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures. 2022 Mar 10 1
4 35408542 Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors. 2022 Mar 26 1
5 32364046 To be ionized or not to be ionized: the vital role of physicochemical properties of galbanic acid derivatives in AChE assay. 2021 Jun 1
6 34361702 Curcumin-Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders. 2021 Jul 28 1
7 34740688 Deciphering the AChE-binding mechanism with multifunctional tricyclic coumarin anti-Alzheimer's agents using biophysical and bioinformatics approaches and evaluation of their modulating effect on Amyloidogenic peptide assembly. 2021 Dec 15 1
8 31838287 New phosphazine and phosphazide derivatives as multifunctional ligands targeting acetylcholinesterase and β-Amyloid aggregation for treatment of Alzheimer's disease. 2020 Jan 2
9 32643792 Synthesis, characterization, molecular docking, and biological activities of coumarin-1,2,3-triazole-acetamide hybrid derivatives. 2020 Oct 3
10 32781220 New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation. 2020 Oct 15 1
11 29663860 Novel coumarin derivatives as potent acetylcholinesterase inhibitors: insight into efficacy, mode and site of inhibition. 2019 Apr 5
12 31125474 Synthesis of 2-(2-oxo-2H-chromen-4-yl)acetamides as potent acetylcholinesterase inhibitors and molecular insights into binding interactions. 2019 Jul 2
13 31479975 Neurobehavioral investigation and acetylcholinesterase inhibitory activity study for some new coumarin derivatives. 2019 Nov 15 1
14 29390885 Multi-targeted directed ligands for Alzheimer's disease: design of novel lead coumarin conjugates. 2018 Mar 2
15 29934672 Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors. 2018 Nov 3
16 30008113 Characterization of the interactions between coumarin-derivatives and acetylcholinesterase: Examination by NMR and docking simulations. 2018 Jul 14 1
17 30515636 Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer's disease. 2018 Dec 4 1
18 28570763 Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties. 2017 Aug 22 2
19 27214510 Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety. 2016 Oct 4 1
20 27230386 Targeting copper(II)-induced oxidative stress and the acetylcholinesterase system in Alzheimer's disease using multifunctional tacrine-coumarin hybrid molecules. 2016 Aug 1
21 27347731 Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. 2016 Jul 28 1
22 26440714 Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. 2015 Dec 3
23 24321276 Immobilized cholinesterases capillary reactors on-flow screening of selective inhibitors. 2014 Oct 1 2
24 25088549 Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, Aβ aggregation, and β-secretase. 2014 Sep 1 2
25 23988412 Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase. 2013 Oct 1
26 24591157 Design, synthesis, biological evaluation, and molecular modeling of coumarin-piperazine derivatives as acetylcholinesterase inhibitors. 2013 Nov 2
27 22257528 A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease. 2012 Feb 1 2
28 23140986 Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors. 2012 Dec 15 3
29 21217689 Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. 2011 Feb 1
30 20677317 Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors. 2010 Sep 3 3
31 17998161 Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. 2008 Jan 1 1
32 18778776 Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. 2008 Sep-Oct 7
33 16182411 Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors. 2005 Dec 1
34 6704184 Binding sites on acetylcholinesterase for reversible ligands and phosphorylating agents. A theoretical model tested on haloxon and phosphostigmine. 1984 Feb 15 1