| 1 |
35630613 | Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors. | 2022 May 13 |
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| 2 |
33930191 | Promising tacrine/huperzine A-based dimeric acetylcholinesterase inhibitors for neurodegenerative disorders: From relieving symptoms to modifying diseases through multitarget. | 2021 Sep |
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| 3 |
34156230 | Dimeric Tacrine(10)-hupyridone as a Multitarget-Directed Ligand To Treat Alzheimer's Disease. | 2021 Jul 7 |
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| 4 |
34363318 | Structural Fractal Analysis of the Active Site of Acetylcholinesterase in Complexes with Huperzine A, Galantamine, and Donepezil. | 2021 Nov |
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| 5 |
34445873 | Pd-Catalyzed Direct Diversification of Natural Anti-Alzheimer's Disease Drug: Synthesis and Biological Evaluation of N-Aryl Huperzine A Analogues. | 2021 Aug 27 |
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| 6 |
34966281 | Integration of System Biology Tools to Investigate Huperzine A as an Anti-Alzheimer Agent. | 2021 |
2 |
| 7 |
32712274 | Slow-binding inhibitors of acetylcholinesterase of medical interest. | 2020 Oct 15 |
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| 8 |
33327436 | The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix. | 2020 Dec 14 |
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| 9 |
30101703 | Phytoconstituents and their Possible Mechanistic Profile for Alzheimer's Disease - A Literature Review. | 2019 |
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| 10 |
31575200 | Frequency domain modeling of quasielastic neutron scattering from hydrated protein powders: Application to free and inhibited human acetylcholinesterase. | 2019 Sep 28 |
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| 11 |
31847089 | Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex. | 2019 Dec 13 |
2 |
| 12 |
29670172 | Acetylcholine and necroptosis are players in follicular development in primates. | 2018 Apr 18 |
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| 13 |
27900576 | Time Course, Behavioral Safety, and Protective Efficacy of Centrally Active Reversible Acetylcholinesterase Inhibitors in Cynomolgus Macaques. | 2017 Jul |
4 |
| 14 |
28110700 | Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer's disease. | 2017 Feb |
4 |
| 15 |
28788095 | Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy. | 2017 Jul 28 |
2 |
| 16 |
29058298 | Pharmacokinetics and tolerability of oral dosage forms of huperzine a in healthy Chinese male volunteers: a randomized, single dose, three-period, six-sequence crossover study. | 2017 Oct |
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| 17 |
26902639 | Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease. | 2016 Apr 5 |
2 |
| 18 |
27605862 | Huperzine A for treatment of cognitive impairment in major depressive disorder: a systematic review of randomized controlled trials. | 2016 Apr 25 |
2 |
| 19 |
25766324 | Readthrough acetylcholinesterase (AChE-R) and regulated necrosis: pharmacological targets for the regulation of ovarian functions? | 2015 Mar 12 |
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| 20 |
25875590 | Development of ESI-MS-based continuous enzymatic assay for real-time monitoring of enzymatic reactions of acetylcholinesterase. | 2015 May 15 |
2 |
| 21 |
26364275 | Safety and Preliminary Efficacy of the Acetylcholinesterase Inhibitor Huperzine A as a Treatment for Cocaine Use Disorder. | 2015 Sep 12 |
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| 22 |
24059299 | Molecular interaction of human brain acetylcholinesterase with a natural inhibitor huperzine-B: an enzoinformatics approach. | 2014 Apr |
5 |
| 23 |
24611490 | A new role for the nonpathogenic nonsynonymous single-nucleotide polymorphisms of acetylcholinesterase in the treatment of Alzheimer's disease: a computational study. | 2014 Aug |
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| 24 |
24872501 | Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds. | 2014 Aug 6 |
2 |
| 25 |
24890706 | Design, synthesis, and evaluation of 7H-thiazolo-[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors. | 2014 Aug |
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| 26 |
23085120 | Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade. | 2013 Mar 25 |
2 |
| 27 |
23229229 | In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile. | 2013 Mar |
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| 28 |
23273608 | Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. | 2013 Feb 1 |
4 |
| 29 |
23399701 | Huperzine A, but not tacrine, stimulates S100B secretion in astrocyte cultures. | 2013 Apr 9 |
2 |
| 30 |
23440190 | Free energy landscape for the binding process of Huperzine A to acetylcholinesterase. | 2013 Mar 12 |
3 |
| 31 |
22932810 | On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis. | 2012 Nov |
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| 32 |
22941287 | New insights into huperzine A for the treatment of Alzheimer's disease. | 2012 Sep |
2 |
| 33 |
23186408 | Energy landscapes of human acetylcholinesterase and its Huperzine A-inhibited counterpart. | 2012 Dec 27 |
2 |
| 34 |
20851778 | Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method. | 2011 Feb |
2 |
| 35 |
21185313 | The effects of huperzine A and IDRA 21 on visual recognition memory in young macaques. | 2011 Jun |
2 |
| 36 |
20452337 | Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. | 2010 Sep 6 |
2 |
| 37 |
20737911 | Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius. | 2010 Jul-Aug |
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| 38 |
21052939 | Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors. | 2010 Oct |
1 |
| 39 |
19110209 | Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets. | 2009 Jan |
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| 40 |
19221692 | Efficacy and safety of natural acetylcholinesterase inhibitor huperzine A in the treatment of Alzheimer's disease: an updated meta-analysis. | 2009 Apr |
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| 41 |
19622237 | Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin. | 2009 Aug |
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| 42 |
19726199 | Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives. | 2009 Oct 1 |
3 |
| 43 |
17657601 | Non-cholinergic effects of huperzine A: beyond inhibition of acetylcholinesterase. | 2008 Feb |
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| 44 |
18555980 | Comparison of methods used for the determination of cholinesterase activity in whole blood. | 2008 Sep 25 |
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| 45 |
18572153 | Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase. | 2008 Sep 25 |
6 |
| 46 |
18789720 | Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization Fourier transform mass spectrometry. | 2008 Dec |
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| 47 |
23480140 | Huprines for Alzheimer's disease drug development. | 2008 Jan |
2 |
| 48 |
17080497 | Simple determination of huperzine A in human plasma by liquid chromatographic-tandem mass spectrometric method. | 2007 Jan |
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| 49 |
17097792 | Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge. | 2007 Apr 20 |
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| 50 |
17945434 | Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. | 2007 Dec 5 |
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