| 51 |
29773682 | Water structure changes in oxime-mediated reactivation process of phosphorylated human acetylcholinesterase. | 2018 Jun 29 |
3 |
| 52 |
29980922 | Influence of gauche effect on uncharged oxime reactivators for the reactivation of tabun-inhibited AChE: quantum chemical and steered molecular dynamics studies. | 2018 Jul |
2 |
| 53 |
30096649 | Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase. | 2018 Sep 5 |
4 |
| 54 |
30110162 | Resurrection Biology: Aged Acetylcholinesterase Brought Back to Life. | 2018 Aug 23 |
1 |
| 55 |
30125110 | Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. | 2018 Sep 13 |
1 |
| 56 |
30265992 | Design, synthesis and evaluation of new classes of nonquaternary reactivators for acetylcholinesterase inhibited by organophosphates. | 2018 Dec |
2 |
| 57 |
30312685 | Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro. | 2018 Dec 15 |
3 |
| 58 |
30362667 | Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor. | 2018 Dec 20 |
2 |
| 59 |
30424582 | Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. | 2018 Nov 12 |
1 |
| 60 |
27358236 | Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6. | 2017 Mar |
1 |
| 61 |
28165084 | Unbinding of fluorinated oxime drug from the AChE gorge in polarizable water: a well-tempered metadynamics study. | 2017 Feb 15 |
1 |
| 62 |
28542985 | Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning. | 2017 Aug |
1 |
| 63 |
28646405 | Revealing the importance of linkers in K-series oxime reactivators for tabun-inhibited AChE using quantum chemical, docking and SMD studies. | 2017 Aug |
1 |
| 64 |
29201079 | Docking Studies, Synthesis, and In-vitro Evaluation of Novel Oximes Based on Nitrones as Reactivators of Inhibited Acetylcholinesterase. | 2017 Summer |
1 |
| 65 |
31294152 | Computational enzymology for degradation of chemical warfare agents: promising technologies for remediation processes. | 2017 |
2 |
| 66 |
31723659 | Methidathion Poisoning. | 2017 Nov |
2 |
| 67 |
25743373 | Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. | 2016 Mar |
2 |
| 68 |
26210933 | Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. | 2016 Feb 26 |
4 |
| 69 |
26612005 | Docking and molecular dynamics studies of peripheral site ligand-oximes as reactivators of sarin-inhibited human acetylcholinesterase. | 2016 Dec |
3 |
| 70 |
26747974 | Evaluation of possible inhibition of human liver drug metabolizing cytochromes P450 by two new acetylcholinesterase oxime-type reactivators. | 2016 Feb |
1 |
| 71 |
26809136 | Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase. | 2016 Mar 30 |
1 |
| 72 |
26851641 | Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds. | 2016 Mar 30 |
2 |
| 73 |
26879641 | The reactivation of tabun-inhibited mutant AChE with Ortho-7: steered molecular dynamics and quantum chemical studies. | 2016 Apr |
1 |
| 74 |
27000635 | Is it possible to reverse aged acetylcholinesterase inhibited by organophosphorus compounds? Insight from the theoretical study. | 2016 Apr 14 |
3 |
| 75 |
27062893 | Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. | 2016 Nov 25 |
2 |
| 76 |
27101948 | Oxime-mediated in vitro reactivation kinetic analysis of organophosphates-inhibited human and electric eel acetylcholinesterase. | 2016 Jun |
3 |
| 77 |
27125761 | Oximes in organophosphate poisoning: 60 years of hope and despair. | 2016 Nov 25 |
2 |
| 78 |
27153754 | Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. | 2016 Mar 28 |
3 |
| 79 |
27191504 | Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interface. | 2016 Sep |
2 |
| 80 |
27238725 | Design and synthesis of N-substituted-2-hydroxyiminoacetamides and interactions with cholinesterases. | 2016 Nov 25 |
2 |
| 81 |
27327269 | Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase. | 2016 Jun |
2 |
| 82 |
27371941 | Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. | 2016 Aug |
7 |
| 83 |
27450532 | Synthesis and in vitro reactivation study of isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as reactivators of Sarin and VX inhibited human acetylcholinesterase (hAChE). | 2016 Sep 15 |
1 |
| 84 |
27494215 | Biological Testing of Organophosphorus-Inactivated Acetylcholinesterase Oxime Reactivators Identified via Virtual Screening. | 2016 Sep 19 |
2 |
| 85 |
27582056 | SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. | 2016 Dec |
1 |
| 86 |
27693733 | Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds. | 2016 Nov 16 |
1 |
| 87 |
24805972 | Oxime-dipeptides as anticholinesterase, reactivator of phosphonylated-serine of AChE catalytic triad: probing the mechanistic insight by MM-GBSA, dynamics simulations and DFT analysis. | 2015 |
1 |
| 88 |
25373357 | Relationships between the antidotal efficacy and structure, PK/PD parameters and bio-relevant molecular descriptors of AChE reactivating oximes: inclusion and integration to biopharmaceutical classification systems. | 2015 Jan |
5 |
| 89 |
25407587 | Molecular modeling and in vitro reactivation study between the oxime BI-6 and acetylcholinesterase inhibited by different nerve agents. | 2015 Sep |
1 |
| 90 |
25451328 | Probing the role of amino acids in oxime-mediated reactivation of nerve agent-inhibited human acetylcholinesterase. | 2015 Mar |
1 |
| 91 |
25522658 | Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. | 2015 Feb 3 |
8 |
| 92 |
25835984 | Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes. | 2015 May 18 |
1 |
| 93 |
25845909 | Universality of Oxime K203 for Reactivation of Nerve Agent-Inhibited AChE. | 2015 |
1 |
| 94 |
26070418 | Synthesis and in vitro kinetic study of novel mono-pyridinium oximes as reactivators of organophosphorus (OP) inhibited human acetylcholinesterase (hAChE). | 2015 Jul 25 |
1 |
| 95 |
26368669 | Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes. | 2015 Dec 25 |
10 |
| 96 |
26468911 | Protein-Drug Interactions with Effective Polarization in Polarizable Water: Oxime Unbinding from AChE Gorge. | 2015 Nov 12 |
2 |
| 97 |
24057572 | In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP). | 2014 Feb |
1 |
| 98 |
24258240 | Oxime-type acetylcholinesterase reactivators in pregnancy: an overview. | 2014 Mar |
1 |
| 99 |
24344993 | Computational evidence for the reactivation process of human acetylcholinesterase inhibited by carbamates. | 2014 |
1 |
| 100 |
24345352 | Interactions between xylene-linked carbamoyl bis-pyridinium mono-oximes and organophosphates inhibited-AChE: a kinetic study. | 2014 Feb 28 |
4 |