| 1 |
33563155 | Synthesis, Molecular Docking, BSA, and In Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase. | 2022 |
1 |
| 2 |
34558680 | Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation†. | 2022 Mar |
3 |
| 3 |
35164361 | Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice. | 2022 Feb 7 |
1 |
| 4 |
35489467 | Theoretical assessment of the performances of commercial oximes on the reactivation of acetylcholinesterase inhibited by the nerve agent A-242 (novichok). | 2022 Jul |
1 |
| 5 |
35526478 | Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents. | 2022 Aug 5 |
5 |
| 6 |
35527825 | Use of connectivity index and simple topological parameters for estimating the inhibition potency of acetylcholinesterase. | 2022 Apr |
1 |
| 7 |
32334495 | Review about Structure and Evaluation of Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds. | 2021 |
1 |
| 8 |
33588047 | Development of a simple QSAR model for reliable evaluation of acetylcholinesterase inhibitor potency. | 2021 May 1 |
2 |
| 9 |
33592259 | Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substituted phenoxyalkyl pyridinium oximes and traditional oximes. | 2021 Mar 30 |
1 |
| 10 |
33990679 | Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase. | 2021 May 14 |
1 |
| 11 |
34019427 | Effect of Oxime Encapsulation on Acetylcholinesterase Reactivation: Pharmacokinetic Study of the Asoxime-Cucurbit[7]uril Complex in Mice Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry. | 2021 Jun 7 |
2 |
| 12 |
34324828 | Covalent inhibition of hAChE by organophosphates causes homodimer dissociation through long-range allosteric effects. | 2021 Sep |
2 |
| 13 |
34330964 | Development of a CNS-permeable reactivator for nerve agent exposure: an iterative, multi-disciplinary approach. | 2021 Jul 30 |
2 |
| 14 |
34541552 | Room temperature crystallography of human acetylcholinesterase bound to a substrate analogue 4K-TMA: Towards a neutron structure. | 2021 |
2 |
| 15 |
34671741 | Dual acting oximes designed for therapeutic decontamination of reactive organophosphates via catalytic inactivation and acetylcholinesterase reactivation. | 2021 Sep 23 |
2 |
| 16 |
31022458 | Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures. | 2020 Jan |
2 |
| 17 |
31830555 | Assessment of false transmitters as treatments for nerve agent poisoning. | 2020 Mar 15 |
1 |
| 18 |
32019865 | Rational design, synthesis, and evaluation of uncharged, "smart" bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. | 2020 Mar 27 |
2 |
| 19 |
32086265 | Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react. | 2020 Apr |
1 |
| 20 |
32105443 | Pharmacokinetic Evaluation of Brain Penetrating Morpholine-3-hydroxy-2-pyridine Oxime as an Antidote for Nerve Agent Poisoning. | 2020 Apr 1 |
1 |
| 21 |
32175496 | Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates. | 2020 Mar 10 |
6 |
| 22 |
32178264 | Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016-2019). | 2020 Mar 12 |
1 |
| 23 |
32267631 | A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma. | 2020 Jul |
2 |
| 24 |
32333945 | Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants. | 2020 Jul |
2 |
| 25 |
32380126 | In vitro evaluation of two different types of obidoxime-loaded nanoparticles for cytotoxicity and blood-brain barrier transport. | 2020 May 5 |
1 |
| 26 |
32388435 | Design, synthesis and evaluation of novel nonquaternary and 3 non-oxime reactivators for acetylcholinesterase inhibited by organophosphates. | 2020 Jul |
3 |
| 27 |
32454005 | Synthesis and in vitro evaluation of novel non-oximes for the reactivation of nerve agent inhibited human acetylcholinesterase. | 2020 Aug 1 |
2 |
| 28 |
32544483 | Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes. | 2020 Sep 15 |
2 |
| 29 |
32835730 | Effect of P-glycoprotein on the availability of oxime reactivators in the brain. | 2020 Oct |
1 |
| 30 |
32899591 | Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects. | 2020 Sep 5 |
1 |
| 31 |
30444932 | Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase. | 2019 Apr 11 |
2 |
| 32 |
30458057 | Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. | 2019 Mar 15 |
4 |
| 33 |
30682493 | Oxidative stress induced by oxime reactivators of acetylcholinesterase in vitro. | 2019 Apr |
1 |
| 34 |
30858091 | The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM). | 2019 Jun 15 |
1 |
| 35 |
30950246 | Prediction of Ligands Binding Acetylcholinesterase with Potential Antidotal Activity: A Virtual Screening Approach. | 2019 Jun |
1 |
| 36 |
30978400 | Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase. | 2019 Jun 1 |
3 |
| 37 |
31074292 | Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach. | 2019 Dec |
1 |
| 38 |
31112674 | Current approaches to enhancing oxime reactivator delivery into the brain. | 2019 Jul 1 |
3 |
| 39 |
31138650 | Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. | 2019 Jul 5 |
3 |
| 40 |
31176713 | A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies. | 2019 Aug 25 |
2 |
| 41 |
31276662 | Reactivation potency of two novel oximes (K456 and K733) against paraoxon-inhibited acetyl and butyrylcholinesterase: In silico and in vitro models. | 2019 Sep 1 |
2 |
| 42 |
28446076 | Behavior of uncharged oximes compared to HI6 and 2-PAM in the human AChE-tabun conjugate: a molecular modeling approach. | 2018 May |
2 |
| 43 |
28722512 | In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication. | 2018 Jan |
3 |
| 44 |
28993240 | The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study. | 2018 Sep 1 |
3 |
| 45 |
29180286 | The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation. | 2018 Sep 1 |
2 |
| 46 |
29553731 | Dynamic Mechanism of a Fluorinated Oxime Reactivator Unbinding from AChE Gorge in Polarizable Water. | 2018 Apr 12 |
1 |
| 47 |
29577198 | Study of the Oxime-induced Reactivation of Acetyl- and Butyrylcholinesterase of Human with Inhibition of Organophosphorus Insecticide In Vitro. | 2018 Mar |
1 |
| 48 |
29614332 | New therapeutic approaches and novel alternatives for organophosphate toxicity. | 2018 Jul |
1 |
| 49 |
29735900 | Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. | 2018 May 7 |
2 |
| 50 |
29772260 | Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations. | 2018 Aug 1 |
3 |