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34029971 | Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment. | 2021 Jul |
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31735356 | Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation. | 2020 Jan |
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31887472 | Design, synthesis, and biological evaluation of ferulic acid based 1,3,4-oxadiazole hybrids as multifunctional therapeutics for the treatment of Alzheimer's disease. | 2020 Jan |
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31271946 | Development of pyrazole and spiropyrazoline analogs as multifunctional agents for treatment of Alzheimer's disease. | 2019 Sep |
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31491074 | Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer's Disease. | 2019 Oct 16 |
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31561043 | Design and development of molecular hybrids of 2-pyridylpiperazine and 5-phenyl-1,3,4-oxadiazoles as potential multifunctional agents to treat Alzheimer's disease. | 2019 Dec 1 |
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27990564 | Planarian cholinesterase: in vitro characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity and reactivation. | 2017 Aug |
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24389509 | 1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies. | 2014 Feb 12 |
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24738476 | New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease. | 2014 May 8 |
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22391555 | Acetylcholinesterase capillary enzyme reactor for screening and characterization of selective inhibitors. | 2013 Jan 25 |
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22814970 | Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase. | 2013 Jan |
2 |
| 12 |
23515568 | Research on the regulation of the spatial structure of acetylcholinesterase tetramer with high efficiency by AFM. | 2013 |
2 |
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22431227 | β-amyloid decreases detectable endothelial nitric oxide synthase in human erythrocytes: a role for membrane acetylcholinesterase. | 2012 Aug |
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19308922 | Tacrine-melatonin hybrids as multifunctional agents for Alzheimer's disease, with cholinergic, antioxidant, and neuroprotective properties. | 2009 May |
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| 15 |
19856923 | Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. | 2009 Nov 26 |
2 |
| 16 |
18468882 | Development of a bifunctional sensor using haptenized acetylcholinesterase and application for the detection of cocaine and organophosphates. | 2008 Sep 15 |
1 |
| 17 |
17005406 | New multipotent tetracyclic tacrines with neuroprotective activity. | 2006 Dec 15 |
2 |
| 18 |
15633997 | Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation. | 2005 Jan 13 |
2 |
| 19 |
15674800 | Synthesis and biological evaluation of tacrine-thiadiazolidinone hybrids as dual acetylcholinesterase inhibitors. | 2005 Jan |
1 |
| 20 |
16230018 | Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE. | 2005 Dec 15 |
1 |
| 21 |
16274232 | Discovery of acetylcholinesterase peripheral anionic site ligands through computational refinement of a directed library. | 2005 Nov 15 |
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| 22 |
16279781 | Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease. | 2005 Nov 17 |
2 |
| 23 |
10648652 | Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease. | 2000 Feb |
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| 24 |
11275256 | Cholinesterase-like catalytic antibodies: reaction with substrates and inhibitors. | 2000 Aug-Sep |
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| 25 |
9890890 | Substrate binding to the peripheral site of acetylcholinesterase initiates enzymatic catalysis. Substrate inhibition arises as a secondary effect. | 1999 Jan 5 |
1 |
| 26 |
10085081 | Organophosphorylation of acetylcholinesterase in the presence of peripheral site ligands. Distinct effects of propidium and fasciculin. | 1999 Mar 26 |
1 |
| 27 |
10329459 | The adhesion function on acetylcholinesterase is located at the peripheral anionic site. | 1999 May 19 |
1 |
| 28 |
10421442 | A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate. | 1999 May 14 |
1 |
| 29 |
10619655 | Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. | 1999 Nov 26 |
1 |
| 30 |
9425034 | Allosteric control of acetylcholinesterase activity by monoclonal antibodies. | 1998 Jan 6 |
2 |
| 31 |
9521743 | Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands. | 1998 Mar 24 |
2 |
| 32 |
9547363 | Acceleration of oxime-induced reactivation of organophosphate-inhibited fetal bovine serum acetylcholinesterase by monoquaternary and bisquaternary ligands. | 1998 Apr |
1 |
| 33 |
9224560 | Reverse-micelle model: pH, electromagnetic field and inhibitor enzyme interaction. | 1997 Jun |
1 |
| 34 |
7492545 | Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite. | 1995 Nov 28 |
1 |
| 35 |
7599168 | Different effects of two peripheral anionic site-binding ligands on acetylcholinesterase active-site gorge topography revealed by electron paramagnetic resonance. | 1995 Jun 12 |
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| 36 |
1538717 | Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase. | 1992 Feb |
1 |
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1986786 | p-Butyroxybenzenediazonium fluoroborate, substrate of acetylcholinesterase and butyrylcholinesterase, discriminates between the two enzymes by a specific affinity labelling. | 1991 Jan 8 |
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1125207 | Interaction of fluorescence probes with acetylcholinesterase. The site and specificity of propidium binding. | 1975 May 6 |
2 |