| 1 |
35023196 | Pro: Oximes should be used routinely in organophosphate poisoning. | 2022 Jan 12 |
2 |
| 2 |
32267631 | A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma. | 2020 Jul |
4 |
| 3 |
32380126 | In vitro evaluation of two different types of obidoxime-loaded nanoparticles for cytotoxicity and blood-brain barrier transport. | 2020 May 5 |
1 |
| 4 |
31074292 | Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach. | 2019 Dec |
1 |
| 5 |
29735900 | Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. | 2018 May 7 |
1 |
| 6 |
30205495 | Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study. | 2018 Sep 7 |
2 |
| 7 |
27358236 | Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6. | 2017 Mar |
1 |
| 8 |
28165084 | Unbinding of fluorinated oxime drug from the AChE gorge in polarizable water: a well-tempered metadynamics study. | 2017 Feb 15 |
1 |
| 9 |
26200596 | Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report. | 2016 Feb 26 |
2 |
| 10 |
26210933 | Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. | 2016 Feb 26 |
1 |
| 11 |
26427931 | Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase. | 2016 |
1 |
| 12 |
26686921 | Highly sensitive electrochemiluminescenc assay of acetylcholinesterase activity based on dual biomarkers using Pd-Au nanowires as immobilization platform. | 2016 May 15 |
2 |
| 13 |
27153754 | Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics. | 2016 Mar 28 |
3 |
| 14 |
24721830 | Synthesis and in vitro evaluation of bis-quaternary 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide derivatives as reactivators against sarin and VX inhibited human acetylcholinesterase (hAChE). | 2014 May 1 |
1 |
| 15 |
24964273 | Can hydroxylamine be a more potent nucleophile for the reactivation of tabun-inhibited AChE than prototype oxime drugs? An answer derived from quantum chemical and steered molecular dynamics studies. | 2014 Jul 29 |
1 |
| 16 |
25240274 | Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes--Possible therapeutic implications. | 2014 Nov 18 |
2 |
| 17 |
22982773 | A common mechanism for resistance to oxime reactivation of acetylcholinesterase inhibited by organophosphorus compounds. | 2013 Mar 25 |
2 |
| 18 |
23111374 | Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents. | 2013 Mar 25 |
1 |
| 19 |
23917882 | Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. | 2013 Aug 2 |
1 |
| 20 |
23962483 | Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates. | 2013 Dec 5 |
2 |
| 21 |
24157926 | Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length. | 2013 Dec 5 |
1 |
| 22 |
22360473 | Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents. | 2012 May 15 |
1 |
| 23 |
23030612 | Structure-activity relationship and efficacy of pyridinium oximes in the treatment of poisoning with organophosphorus compounds: a review of recent data. | 2012 |
1 |
| 24 |
20027669 | Design, evaluation and structure-activity relationship studies of the AChE reactivators against organophosphorus pesticides. | 2011 Jul |
1 |
| 25 |
21673941 | In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. | 2011 |
5 |
| 26 |
21983245 | Potential of two new oximes in reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by organophosphate compounds: an in vitro study. | 2011 Dec |
1 |
| 27 |
19917271 | Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations. | 2010 Sep 6 |
2 |
| 28 |
20105433 | Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship? | 2010 Sep 6 |
1 |
| 29 |
20510679 | Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds. | 2010 Sep 15 |
1 |
| 30 |
21152278 | Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro. | 2010 Aug 3 |
1 |
| 31 |
19429253 | Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study. | 2009 Jun 1 |
1 |
| 32 |
19519385 | Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. | 2009 |
1 |
| 33 |
19651196 | Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. | 2009 Oct 28 |
1 |
| 34 |
19778163 | Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness. | 2009 Sep |
2 |
| 35 |
19778190 | Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships. | 2009 Sep |
1 |
| 36 |
20032868 | Novel bisquaternary oximes--reactivation of acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon. | 2009 Dec 1 |
1 |
| 37 |
17977518 | Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity. | 2008 Feb 1 |
1 |
| 38 |
18588863 | Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity. | 2008 Sep 25 |
2 |
| 39 |
18617161 | Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro. | 2008 Sep 25 |
2 |
| 40 |
18804659 | Improvement of acetylcholinesterase-based assay for organophosphates in way of identification by reactivators. | 2008 Oct 19 |
2 |
| 41 |
16904807 | Simulation of cholinesterase status at different scenarios of nerve agent exposure. | 2007 Apr 20 |
2 |
| 42 |
17112559 | Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis. | 2007 Mar |
1 |
| 43 |
17370251 | Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro. | 2007 Nov-Dec |
2 |
| 44 |
17382909 | Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates. | 2007 Jun 1 |
3 |
| 45 |
17714697 | Preparation and characterization of dialkylphosphoryl-obidoxime conjugates, potent anticholinesterase derivatives that are quickly hydrolyzed by human paraoxonase (PON1192Q). | 2007 Nov 1 |
1 |
| 46 |
18254274 | Evaluation of potency of known oximes (pralidoxime, trimedoxime, HI-6, methoxime, obidoxime) to in vitro reactivate acetylcholinesterase inhibited by pesticides (chlorpyrifos and methylchlorpyrifos) and nerve agent (Russian VX). | 2007 |
3 |
| 47 |
16971069 | Hydrolysis of an acetylthiocholine by pralidoxime iodide (2-PAM). | 2006 Oct 25 |
1 |
| 48 |
17194021 | Synthesis, characterization and inhibitory potency of two oxono and thiono analogues of phosphoramidate compounds on acetylcholinesterase. | 2006 Oct |
1 |
| 49 |
18072133 | Reactivation of sarin-inhibited pig brain acetylcholinesterase using oxime antidotes. | 2006 Dec |
1 |
| 50 |
15904945 | Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model. | 2005 Dec 15 |
2 |