Organophosphorus Compounds

acetylcholinesterase (Cartwright blood group) ; Homo sapiens







48 Article(s)
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1 33592259 Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substituted phenoxyalkyl pyridinium oximes and traditional oximes. 2021 Mar 30 4
2 34185362 Molecular Recognition of Nerve Agents and Their Organophosphorus Surrogates: Toward Supramolecular Scavengers and Catalysts. 2021 Sep 20 4
3 32333945 Efficient detoxification of nerve agents by oxime-assisted reactivation of acetylcholinesterase mutants. 2020 Jul 1
4 30027640 Reversible cholinesterase inhibitors as pretreatment for exposure to organophosphates. A review. 2019 Jan 4
5 30458057 Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase. 2019 Mar 15 4
6 30938485 Polydopamine-Capped Bimetallic AuPt Hydrogels Enable Robust Biosensor for Organophosphorus Pesticide Detection. 2019 Apr 2
7 30950246 Prediction of Ligands Binding Acetylcholinesterase with Potential Antidotal Activity: A Virtual Screening Approach. 2019 Jun 4
8 31138650 Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. 2019 Jul 5 2
9 29024789 In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers. 2018 Sep 1 1
10 29180286 The estimation of oxime efficiency is affected by the experimental design of phosphylated acetylcholinesterase reactivation. 2018 Sep 1 2
11 29248576 Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning. 2018 Sep 1 2
12 29772260 Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations. 2018 Aug 1 2
13 30312685 Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro. 2018 Dec 15 2
14 25743373 Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. 2016 Mar 4
15 26210933 Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase. 2016 Feb 26 2
16 26851641 Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds. 2016 Mar 30 2
17 25522658 Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase. 2015 Feb 3 2
18 25828536 Small-scale purification of butyrylcholinesterase from human plasma and implementation of a μLC-UV/ESI MS/MS method to detect its organophosphorus adducts. 2015 Oct 1
19 24057572 In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP). 2014 Feb 1
20 24413757 Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox. 2014 Jan 9 2
21 25050413 Lab-on-a-drop: biocompatible fluorescent nanoprobes of gold nanoclusters for label-free evaluation of phosphorylation-induced inhibition of acetylcholinesterase activity towards the ultrasensitive detection of pesticide residues. 2014 Sep 21 4
22 23047024 The cholinergic and non-cholinergic effects of organophosphates and oximes in cultured human myoblasts. 2013 Mar 25 2
23 21998030 Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning. 2012 Mar-Apr 2
24 22561105 Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase. 2012 Jul 7 2
25 20669006 Effect of different buffers on kinetic properties of human acetylcholinesterase and the interaction with organophosphates and oximes. 2011 Mar 2
26 20807085 Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach. 2011 Jun 1
27 21144749 Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128. 2011 Jan 1 3
28 21451868 First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase. 2011 May 14 2
29 21470076 Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species. 2011 Sep 2
30 21930118 Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis. 2011 Nov 15 1
31 19883634 Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning. 2010 Sep 6 2
32 20156534 Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon. 2010 May 4 1
33 20542100 Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds. 2010 Sep 1 4
34 20882513 Chromatographic analysis of toxic phosphylated oximes (POX): a brief overview. 2010 Oct 2
35 19526299 Efficacy of eight experimental bispyridinium oximes against paraoxon-induced mortality: comparison with the conventional oximes pralidoxime and obidoxime. 2009 Jul 4
36 17456837 Unequal efficacy of pyridinium oximes in acute organophosphate poisoning. 2007 Mar 2
37 17913691 Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds. 2007 Sep 3
38 16780806 Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds. 2006 Jul 28 1
39 15762562 Acetylcholinesterase-based organophosphate nerve agent sensing photonic crystal. 2005 Mar 15 2
40 16119193 A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents. 2005 Jun 2
41 16266695 Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach. 2005 Dec 15 1
42 16293236 Bioscavengers for the protection of humans against organophosphate toxicity. 2005 Dec 15 3
43 12706567 Optical biosensor for simultaneous detection of captan and organophosphorus compounds. 2003 May 2
44 11679273 Optical organophosphorus biosensor consisting of acetylcholinesterase/viologen hetero Langmuir-Blodgett film. 2001 Dec 1
45 9587020 Reactivating potency of obidoxime, pralidoxime, HI 6 and HLö 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. 1998 Mar 1
46 9268605 Acetylcholinesterase and neuropathy target esterase inhibitions in neuroblastoma cells to distinguish organophosphorus compounds causing acute and delayed neurotoxicity. 1997 Jul 3
47 3699334 Kinetic studies and structure-activity relationships of bispyridinium oximes as reactivators of acetylcholinesterase inhibited by organophosphorus compounds. 1986 Apr 1
48 5315349 Relationships between the structure of organophosphorus compounds and their activity as acetylcholinesterase inhibitors. 1971 1