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33984771 | Structural insight into transmissive mutant huntingtin species by correlative light and electron microscopy and cryo-electron tomography. | 2021 Jun 30 |
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32574646 | Validation of behavioral phenotypes in the BACHD rat model. | 2020 Sep 1 |
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32675242 | Site-specific ubiquitination of pathogenic huntingtin attenuates its deleterious effects. | 2020 Aug 4 |
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32975927 | Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease. | 2020 Oct 20 |
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30916978 | Application of an in Vitro Blood-Brain Barrier Model in the Selection of Experimental Drug Candidates for the Treatment of Huntington's Disease. | 2019 May 6 |
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30171891 | Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease. | 2018 Dec |
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27717053 | Coupling of D2R Short but not D2R Long receptor isoform to the Rho/ROCK signaling pathway renders striatal neurons vulnerable to mutant huntingtin. | 2017 Jan |
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27984179 | Immunohistochemical analysis of huntingtin-associated protein 1 in adult rat spinal cord and its regional relationship with androgen receptor. | 2017 Jan 6 |
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28499347 | The dynamics of early-state transcriptional changes and aggregate formation in a Huntington's disease cell model. | 2017 May 12 |
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27271685 | Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. | 2016 |
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27751235 | Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract. | 2016 Oct 18 |
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25744490 | HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic β cells. | 2015 Jul |
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24352657 | scyllo-Inositol promotes robust mutant Huntingtin protein degradation. | 2014 Feb 7 |
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| 14 |
23392662 | MAP kinase phosphatase 1 (MKP-1/DUSP1) is neuroprotective in Huntington's disease via additive effects of JNK and p38 inhibition. | 2013 Feb 6 |
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| 15 |
23720495 | A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin. | 2013 Oct 1 |
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23799534 | Dose-dependent neuroprotection of VEGF₁₆₅ in Huntington's disease striatum. | 2013 Oct |
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22410294 | Expression of mutant N-terminal huntingtin fragment (htt552-100Q) in astrocytes suppresses the secretion of BDNF. | 2012 Apr 17 |
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21452052 | Modeling pathogenesis of Huntington's disease with inducible neuroprogenitor cells. | 2011 Jul |
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21079601 | Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. | 2010 Dec |
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19022249 | Implication of the JNK pathway in a rat model of Huntington's disease. | 2009 Jan |
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| 21 |
19247483 | Normal aging modulates the neurotoxicity of mutant huntingtin. | 2009 |
2 |
| 22 |
19352548 | High efficiency adenovirus-mediated expression of truncated N-terminal huntingtin fragment (htt552) in primary rat astrocytes. | 2009 Apr |
2 |
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19559011 | ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line. | 2009 Aug 25 |
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17905594 | Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo. | 2008 Jan |
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18255062 | Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins. | 2008 Mar 10 |
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18753376 | Suppression of mutant Huntingtin aggregate formation by Cdk5/p35 through the effect on microtubule stability. | 2008 Aug 27 |
2 |
| 27 |
19015277 | Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. | 2008 Dec 1 |
3 |
| 28 |
16330479 | Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. | 2006 Jan 15 |
4 |
| 29 |
16452687 | Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421. | 2006 Feb 1 |
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16641246 | CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity. | 2006 Apr 26 |
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15689617 | cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues. | 2005 Apr 8 |
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15908226 | Compounds blocking mutant huntingtin toxicity identified using a Huntington's disease neuronal cell model. | 2005 Nov |
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16033418 | Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation. | 2005 Aug |
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16087879 | Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. | 2005 Aug 16 |
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15262266 | A cell-based screen for drugs to treat Huntington's disease. | 2004 Aug |
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15325591 | Microtubule disruption inhibits autophagosome-lysosome fusion: implications for studying the roles of aggresomes in polyglutamine diseases. | 2004 Dec |
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12559971 | In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. | 2003 Feb 1 |
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| 38 |
12657886 | Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation. | 2003 Mar 24 |
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| 39 |
12799135 | Mutant huntingtin increases nuclear corepressor function and enhances ligand-dependent nuclear hormone receptor activation. | 2003 May |
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| 40 |
12952868 | Early and reversible neuropathology induced by tetracycline-regulated lentiviral overexpression of mutant huntingtin in rat striatum. | 2003 Nov 1 |
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| 41 |
12957494 | Huntingtin is degraded to small fragments by calpain after ischemic injury. | 2003 Sep |
2 |
| 42 |
11733534 | Expression of full-length polyglutamine-expanded Huntingtin disrupts growth factor receptor signaling in rat pheochromocytoma (PC12) cells. | 2002 Feb 22 |
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11978824 | Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels, and protein length. | 2002 May 1 |
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12217956 | Modulation of polyglutamine-induced cell death by genes identified by expression profiling. | 2002 Sep 15 |
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12226089 | Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion. | 2002 Nov 15 |
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10964480 | Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid. | 2000 Sep |
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9880591 | Generation of neuronal intranuclear inclusions by polyglutamine-GFP: analysis of inclusion clearance and toxicity as a function of polyglutamine length. | 1999 Jan 15 |
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10377328 | Cellular defects and altered gene expression in PC12 cells stably expressing mutant huntingtin. | 1999 Jul 1 |
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9454836 | Interaction of huntingtin-associated protein with dynactin P150Glued. | 1998 Feb 15 |
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9786889 | Expression of polyglutamine-expanded Huntingtin activates the SEK1-JNK pathway and induces apoptosis in a hippocampal neuronal cell line. | 1998 Oct 30 |
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