lysophosphatidic acid

AKT serine/threonine kinase 1 ; Homo sapiens







67 Article(s)
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1 33367557 Lysophosphatidic acid mediated PI3K/Akt activation contributed to esophageal squamous cell cancer progression. 2021 Apr 30 2
2 33815123 High Expression of Lysophosphatidic Acid Induces Nerve Injury in LSS Patients via AKT Mediated NF-κB p65 Pathway. 2021 2
3 34065317 Discoidin Domain Receptor 2 Mediates Lysophosphatidic Acid-Induced Ovarian Cancer Aggressiveness. 2021 May 20 1
4 34639115 Lysophosphatidic Acid Mediates Imiquimod-Induced Psoriasis-like Symptoms by Promoting Keratinocyte Proliferation through LPAR1/ROCK2/PI3K/AKT Signaling Pathway. 2021 Oct 5 2
5 34886812 Amelioration of human peritoneal mesothelial cell co-culture-evoked malignant potential of ovarian cancer cells by acacetin involves LPA release-activated RAGE-PI3K/AKT signaling. 2021 Dec 9 1
6 32297350 Experimental Biology 2020 Meeting Abstracts. 2020 Apr 1
7 32774171 Potential interaction between lysophosphatidic acid and tumor-associated macrophages in ovarian carcinoma. 2020 2
8 32920014 Lysophosphatidic acid receptor 5 transactivation of TGFBR1 stimulates the mRNA expression of proteoglycan synthesizing genes XYLT1 and CHST3. 2020 Dec 1
9 31636669 Diverse Effects of Lysophosphatidic Acid Receptors on Ovarian Cancer Signaling Pathways. 2019 1
10 29466791 Lysophosphatidic Acid Induces Ligamentum Flavum Hypertrophy Through the LPAR1/Akt Pathway. 2018 3
11 27994056 Inducible Inhibition of Gβγ Reveals Localization-dependent Functions at the Plasma Membrane and Golgi. 2017 Feb 3 1
12 28232483 Ectodomain shedding of the cell adhesion molecule Nectin-4 in ovarian cancer is mediated by ADAM10 and ADAM17. 2017 Apr 14 1
13 28359316 Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device. 2017 Mar 31 1
14 29046393 Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ. 2017 Nov 16 1
15 26386720 Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells. 2016 Feb 1
16 26800320 Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism. 2016 Mar 1
17 26861299 G-Protein-Coupled Lysophosphatidic Acid Receptors and Their Regulation of AKT Signaling. 2016 Feb 5 1
18 25633408 Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis. 2015 Mar 1
19 25783839 Attenuation of LPS-induced cyclooxygenase-2 and inducible NO synthase expression by lysophosphatidic acid in macrophages. 2015 Aug 2
20 25975684 [Lysophosphatidic acid (LPA) stimulates invasion and metastatic colonization of ovarian cancer cells through Rac activation]. 2015 Feb 9
21 26171059 Type II cyclic guanosine monophosphate-dependent protein kinase inhibits Rac1 activation in gastric cancer cells. 2015 Jul 4
22 26366416 Lysophosphatidic Acid Inhibits Apoptosis Induced by Cisplatin in Cervical Cancer Cells. 2015 3
23 25424429 Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. 2014 1
24 23618389 The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells. 2013 Apr 24 1
25 23808384 Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice. 2013 Dec 1
26 23919615 ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells. 2013 Aug 6 1
27 21925926 Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. 2012 Jan 1
28 22049212 Integrin α6β4 cooperates with LPA signaling to stimulate Rac through AKAP-Lbc-mediated RhoA activation. 2012 Feb 1 3
29 22159277 LPA stimulates intestinal DRA gene transcription via LPA2 receptor, PI3K/AKT, and c-Fos-dependent pathway. 2012 Mar 15 1
30 22627809 Synergistic induction of cancer cell migration regulated by Gβγ and phosphatidylinositol 3-kinase. 2012 Aug 31 1
31 23137199 Enhanced Akt phosphorylation and myogenic differentiation in PI3K p110β-deficient myoblasts is mediated by PI3K p110α and mTORC2. 2012 Dec 1
32 21915944 Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3. 2011 Nov 1
33 19906815 Lysophosphatidic acid up-regulates expression of growth-regulated oncogene-alpha, interleukin-8, and monocyte chemoattractant protein-1 in human first-trimester trophoblasts: possible roles in angiogenesis and immune regulation. 2010 Jan 1
34 19910524 Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl-/OH- exchange. 2010 Feb 1
35 20533299 LPA rescues ER stress-associated apoptosis in hypoxia and serum deprivation-stimulated mesenchymal stem cells. 2010 Nov 1 4
36 20576526 Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes. 2010 Oct 1 1
37 20861350 Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells. 2010 Oct 15 1
38 20934509 Reactive oxygen species mediate lysophosphatidic acid induced signaling in ovarian cancer cells. 2010 Dec 15 1
39 19461126 Lysophosphatidic acid inhibits the cytotoxic activity of NK cells: involvement of Gs protein-mediated signaling. 2009 Jun 1
40 19864456 Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. 2009 Dec 1
41 18779657 Lysophosphatidic acid induces cell migration through the selective activation of Akt1. 2008 Aug 31 4
42 17236191 Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy. 2007 Apr 1 1
43 17251460 Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor. 2007 Feb 1
44 15920762 Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs. 2006 Jan 2
45 16301320 Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. 2006 Jan 27 2
46 16760261 Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line. 2006 Nov 3
47 16882668 Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells. 2006 Sep 29 1
48 17085645 Activation of hypoxia-inducible factor-1alpha is necessary for lysophosphatidic acid-induced vascular endothelial growth factor expression. 2006 Nov 1 1
49 15471896 Up-regulation of interleukin-6 in human ovarian cancer cell via a Gi/PI3K-Akt/NF-kappaB pathway by lysophosphatidic acid, an ovarian cancer-activating factor. 2005 Jan 4
50 15618220 Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB. 2005 Mar 11 3