| 1 |
34111424 | C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation. | 2021 Aug |
1 |
| 2 |
34461224 | Simvastatin modulates estrogen signaling in uterine leiomyoma via regulating receptor palmitoylation, trafficking and degradation. | 2021 Oct |
1 |
| 3 |
34799978 | Simvastatin treatment promotes proliferation of human dental pulp stem cells via modulating PI3K/AKT/miR-9/KLF5 signalling pathway. | 2021 Dec |
9 |
| 4 |
34843676 | Simvastatin potentiates the cell-killing activity of imatinib in imatinib-resistant chronic myeloid leukemia cells mainly through PI3K/AKT pathway attenuation and Myc downregulation. | 2021 Dec 15 |
2 |
| 5 |
32172201 | Inverse screening of Simvastatin kinase targets from glioblastoma druggable kinome. | 2020 Jun |
1 |
| 6 |
33042440 | Simvastatin ameliorates oxygen glucose deprivation/reoxygenation-induced pulmonary endothelial barrier dysfunction by restoring cell-cell junctions and actin cytoskeleton dynamics via the PI3K/Akt signaling pathway. | 2020 |
1 |
| 7 |
33295884 | Simvastatin profoundly impairs energy metabolism in primary human muscle cells. | 2020 Nov |
1 |
| 8 |
31092879 | Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells. | 2019 May 15 |
2 |
| 9 |
31452046 | Anti-leukemic effects of simvastatin on NRASG12D mutant acute myeloid leukemia cells. | 2019 Dec |
1 |
| 10 |
31576676 | Simvastatin preparations promote PDGF-BB secretion to repair LPS-induced endothelial injury through the PDGFRβ/PI3K/Akt/IQGAP1 signalling pathway. | 2019 Dec |
4 |
| 11 |
31839714 | Statins induce cell apoptosis through a modulation of AKT/FOXO1 pathway in prostate cancer cells. | 2019 |
2 |
| 12 |
29208461 | Simvastatin inhibits the development of radioresistant esophageal cancer cells by increasing the radiosensitivity and reversing EMT process via the PTEN-PI3K/AKT pathway. | 2018 Jan 15 |
4 |
| 13 |
29257256 | Simvastatin ameliorates cognitive impairments via inhibition of oxidative stress‑induced apoptosis of hippocampal cells through the ERK/AKT signaling pathway in a rat model of senile dementia. | 2018 Jan |
1 |
| 14 |
29435052 | Simvastatin in combination with meclofenamic acid inhibits the proliferation and migration of human prostate cancer PC-3 cells via an AKR1C3 mechanism. | 2018 Mar |
3 |
| 15 |
29865262 | Differential Effects of Statins on Inflammatory Interleukin-8 and Antimicrobial Peptide Human Β-Defensin 2 Responses in Salmonella-Infected Intestinal Epithelial Cells. | 2018 Jun 2 |
1 |
| 16 |
28554582 | Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1. | 2017 Aug |
2 |
| 17 |
26470769 | Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells. | 2016 Mar |
1 |
| 18 |
26565813 | Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway. | 2016 Jan 19 |
5 |
| 19 |
27323826 | Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. | 2016 Jul 19 |
3 |
| 20 |
27347133 | Statin induces apoptosis of human colon cancer cells and downregulation of insulin-like growth factor 1 receptor via proapoptotic ERK activation. | 2016 Jul |
2 |
| 21 |
27470565 | Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signaling in C2C12 myotubes. | 2016 Oct |
4 |
| 22 |
27743890 | Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation. | 2016 Nov 11 |
2 |
| 23 |
27779188 | Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway. | 2016 Oct 25 |
1 |
| 24 |
25520153 | Synergistic Effect of Sulindac and Simvastatin on Apoptosis in Lung Cancer A549 Cells through AKT-Dependent Downregulation of Survivin. | 2015 Jan |
3 |
| 25 |
26304753 | Role of phosphatase activity of soluble epoxide hydrolase in regulating simvastatin-activated endothelial nitric oxide synthase. | 2015 Aug 25 |
3 |
| 26 |
26334381 | Simvastatin protects the heart against ischemia reperfusion injury via inhibiting HMGB1 expression through PI3K/Akt signal pathways. | 2015 Dec 15 |
1 |
| 27 |
23901824 | Mitophagy is required for acute cardioprotection by simvastatin. | 2014 Nov 10 |
1 |
| 28 |
24631288 | Effect of simvastatin on the resistance to EGFR tyrosine kinase inhibitors in a non-small cell lung cancer with the T790M mutation of EGFR. | 2014 May 1 |
3 |
| 29 |
24880141 | Simvastatin, an HMG-CoA reductase inhibitor, exhibits anti-metastatic and anti-tumorigenic effects in endometrial cancer. | 2014 Aug |
3 |
| 30 |
24887036 | High density lipoprotein from patients with valvular heart disease uncouples endothelial nitric oxide synthase. | 2014 Sep |
1 |
| 31 |
25023790 | HMG-CoA reductase inhibition prior reperfusion improves reparative fibrosis post-myocardial infarction in a preclinical experimental model. | 2014 Aug 20 |
1 |
| 32 |
25122066 | Synergistic simvastatin and metformin combination chemotherapy for osseous metastatic castration-resistant prostate cancer. | 2014 Oct |
1 |
| 33 |
23603515 | Rituximab activates Syk and AKT in CD20-positive B cell lymphoma cells dependent on cell membrane cholesterol levels. | 2013 Aug |
1 |
| 34 |
23690956 | Simvastatin inhibits renal cancer cell growth and metastasis via AKT/mTOR, ERK and JAK2/STAT3 pathway. | 2013 |
3 |
| 35 |
23947572 | Statins in lymphangioleiomyomatosis. Simvastatin and atorvastatin induce differential effects on tuberous sclerosis complex 2-null cell growth and signaling. | 2013 Nov |
1 |
| 36 |
23973711 | Statin induces inhibition of triple negative breast cancer (TNBC) cells via PI3K pathway. | 2013 Sep 20 |
3 |
| 37 |
20946258 | Simvastatin inhibits glucose-stimulated vascular smooth muscle cell migration involving increased expression of RhoB and a block of Ras/Akt signal. | 2012 Apr |
2 |
| 38 |
21871960 | Inhibition of AMPK-dependent autophagy enhances in vitro antiglioma effect of simvastatin. | 2012 Jan |
2 |
| 39 |
22541079 | [Effects of simvastatin on PI3K/AKT signaling pathway in human acute monocytic leukemia cell line SHI-1]. | 2012 Apr |
1 |
| 40 |
22796581 | Simvastatin reduces myocardial injury undergoing noncoronary artery cardiac surgery: a randomized controlled trial. | 2012 Sep |
1 |
| 41 |
22918643 | Effects of simvastatin on the expression of heme oxygenase-1 in human RPE cells. | 2012 Sep 21 |
2 |
| 42 |
22974127 | Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis. | 2012 Sep 14 |
1 |
| 43 |
23026078 | Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons. | 2012 Nov 27 |
2 |
| 44 |
20464445 | Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. | 2011 Oct |
3 |
| 45 |
21059805 | Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and reduced prostate-specific antigen expression. | 2011 Feb |
6 |
| 46 |
21395587 | Simvastatin alters fibroblastic cell responses involved in tissue repair. | 2011 Aug |
1 |
| 47 |
21839782 | Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt. | 2011 Dec |
1 |
| 48 |
20060890 | Simvastatin induces derepression of PTEN expression via NFkappaB to inhibit breast cancer cell growth. | 2010 May |
1 |
| 49 |
20562903 | Simvastatin combined with nifedipine enhances endothelial cell protection by inhibiting ROS generation and activating Akt phosphorylation. | 2010 Jul |
1 |
| 50 |
20594940 | Simvastatin-dependent up-regulation of heme oxygenase-1 via mRNA stabilization in human endothelial cells. | 2010 Sep 11 |
1 |