Lovastatin

AKT serine/threonine kinase 1 ; Homo sapiens







25 Article(s)
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Title
Pub. Year
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1 33742146 Kinome-wide analysis of the effect of statins in colorectal cancer. 2021 Jun 1
2 31662972 Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells. 2019 1
3 28968593 GSK3α/β: A Novel Therapeutic Target for Neuroendocrine Tumors. 2018 1
4 29207042 Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages. 2018 Feb 1
5 26931464 Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity. 2016 May 15 7
6 25569448 Blockade of the Ras/Raf/ERK and Ras/PI3K/Akt Pathways by Monacolin K Reduces the Expression of GLO1 and Induces Apoptosis in U937 Cells. 2015 Feb 4 3
7 26208883 Differentiation and apoptosis induction by lovastatin and γ-tocotrienol in HL-60 cells via Ras/ERK/NF-κB and Ras/Akt/NF-κB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase. 2015 Nov 2
8 26636335 Additive Anti-Tumor Effects of Lovastatin and Everolimus In Vitro through Simultaneous Inhibition of Signaling Pathways. 2015 2
9 23764197 The role of RhoC in ovarian epithelial carcinoma: a marker for carcinogenesis, progression, prognosis, and target therapy. 2013 Sep 1
10 21258249 Lovastatin sensitizes lung cancer cells to ionizing radiation: modulation of molecular pathways of radioresistance and tumor suppression. 2011 Mar 2
11 21624609 Lovastatin causes diminished PSA secretion by inhibiting AR expression and function in LNCaP prostate cancer cells. 2011 Jun 1
12 21660955 Lipid raft localization of EGFR alters the response of cancer cells to the EGFR tyrosine kinase inhibitor gefitinib. 2011 Sep 1
13 19760159 Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations. 2010 Dec 2
14 20562912 Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins. 2010 Aug 19 3
15 20838437 Lovastatin inhibits VEGFR and AKT activation: synergistic cytotoxicity in combination with VEGFR inhibitors. 2010 Sep 3 4
16 19417733 Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL. 2009 May 2
17 19787257 Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. 2009 Nov 1
18 18376053 Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways. 2008 Mar 2
19 17050804 Human chorionic gonadotropin modulates prostate cancer cell survival after irradiation or HMG CoA reductase inhibitor treatment. 2007 Jan 1
20 17158337 Critical role for FoxO3a-dependent regulation of p21CIP1/WAF1 in response to statin signaling in cardiac myocytes. 2007 Jan 5 1
21 17179158 Statin-induced Ras activation integrates the phosphatidylinositol 3-kinase signal to Akt and MAPK for bone morphogenetic protein-2 expression in osteoblast differentiation. 2007 Feb 16 1
22 17472962 Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer. 2007 Jul 6 1
23 16968805 Direct demonstration of an antiinflammatory effect of simvastatin in subjects with the metabolic syndrome. 2006 Nov 1
24 15788691 Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor. 2005 Mar 15 1
25 15953363 Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. 2005 Jul 4