bufalin

AKT serine/threonine kinase 1 ; Homo sapiens







35 Article(s)
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1 35126601 Therapeutic Targets of Bufalin on Renal Carcinoma and Mechanisms: Experimental Validation of Network Pharmacology Analysis. 2022 1
2 33530915 Effect of PI3K/AKT/mTOR Signaling Pathway on Regulating and Controlling the Anti-Invasion and Metastasis of Hepatoma Cells by Bufalin. 2021 2
3 34512368 Targeting Autophagy with Natural Compounds in Cancer: A Renewed Perspective from Molecular Mechanisms to Targeted Therapy. 2021 1
4 34935692 Bufalin suppresses ovarian cancer cell proliferation via EGFR pathway. 2021 Dec 22 2
5 32231716 Anti-tumor Activity of Bufalin by Inhibiting c-MET Mediated MEK/ERK and PI3K/AKT Signaling Pathways in Gallbladder Cancer. 2020 1
6 33148004 Bufalin: A Systematic Review of Research Hotspots and Antitumor Mechanisms by Text Mining and Bioinformatics. 2020 1
7 30468278 Bufalin induces protective autophagy by Cbl-b regulating mTOR and ERK signaling pathways in gastric cancer cells. 2019 Jan 1
8 29568394 Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway. 2018 Mar 2 1
9 29622868 Bufalin Enhances the Cytotoxity of Human Multiple Myeloma Cells H929 to AKT Inhibitor MK2206: The Role of Protein AKT Phosphorylation. 2018 Apr 2
10 30128000 Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway. 2018 Sep 3
11 28492559 MK2206 enhances the cytocidal effects of bufalin in multiple myeloma by inhibiting the AKT/mTOR pathway. 2017 May 11 4
12 26662961 The effects of bufadienolides on HER2 overexpressing breast cancer cells. 2016 Jun 1
13 26758421 Bufalin enhances antitumor effect of paclitaxel on cervical tumorigenesis via inhibiting the integrin α2/β5/FAK signaling pathway. 2016 Feb 23 1
14 26782953 Bufalin enhances anti-angiogenic effect of sorafenib via AKT/VEGF signaling. 2016 Mar 2
15 26958938 Bufalin suppresses hepatocellular carcinoma invasion and metastasis by targeting HIF-1α via the PI3K/AKT/mTOR pathway. 2016 Apr 12 2
16 27357249 Bufalin reverses intrinsic and acquired drug resistance to cisplatin through the AKT signaling pathway in gastric cancer cells. 2016 Aug 4
17 27425252 Inhibition of SRC-3 enhances sensitivity of human cancer cells to histone deacetylase inhibitors. 2016 Sep 9 1
18 27507851 Knockdown of Apolipoprotein E Enhanced Sensitivity of Hep3B Cells to Cardiac Steroids via Regulating Na+/K+-ATPase Signalosome. 2016 Dec 1
19 23949904 Bufalin inhibits migration and invasion in human hepatocellular carcinoma SK-Hep1 cells through the inhibitions of NF-kB and matrix metalloproteinase-2/-9-signaling pathways. 2015 Jan 2
20 26381511 Bufalin Reverses Resistance to Sorafenib by Inhibiting Akt Activation in Hepatocellular Carcinoma: The Role of Endoplasmic Reticulum Stress. 2015 4
21 26463323 [Bufalin reverses hepatocyte growth factor-induced resistance to afatinib in H1975 lung cancer cells]. 2015 Jul 2
22 26770191 Bufalin Inhibits HCT116 Colon Cancer Cells and Its Orthotopic Xenograft Tumor in Mice Model through Genes Related to Apoptotic and PTEN/AKT Pathways. 2015 1
23 24581171 Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice. 2014 Feb 28 2
24 23533466 Bufalin Reverses HGF-Induced Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer Cells via Blockage of Met/PI3k/Akt Pathway and Induction of Apoptosis. 2013 2
25 23799775 Discovery of bufadienolides as a novel class of ClC-3 chloride channel activators with antitumor activities. 2013 Jul 25 1
26 23870199 Bufalin, a component in Chansu, inhibits proliferation and invasion of hepatocellular carcinoma cells. 2013 Jul 19 2
27 24325059 [Effect of bufalin combined gefitinib on lung cancer H1975 cells and its mechanisms research]. 2013 Aug 1
28 21617941 Bufalin enhances the anti-proliferative effect of sorafenib on human hepatocellular carcinoma cells through downregulation of ERK. 2012 Feb 2
29 22285700 Bufalin induces G0/G1 phase arrest through inhibiting the levels of cyclin D, cyclin E, CDK2 and CDK4, and triggers apoptosis via mitochondrial signaling pathway in T24 human bladder cancer cells. 2012 Apr 1 1
30 22408435 Bufalin induces lung cancer cell apoptosis via the inhibition of PI3K/Akt pathway. 2012 5
31 22858649 Bufalin increases sensitivity to AKT/mTOR-induced autophagic cell death in SK-HEP-1 human hepatocellular carcinoma cells. 2012 Oct 1
32 22922805 AKT serine/threonine protein kinase modulates bufalin-triggered intrinsic pathway of apoptosis in CAL 27 human oral cancer cells. 2012 Nov 5
33 21181095 Na+/K+-ATPase α3 mediates sensitivity of hepatocellular carcinoma cells to bufalin. 2011 Mar 1
34 20963488 Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action. 2010 Dec 2
35 19343001 PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells. 2009 Jan 3