NVP-BKM120

AKT serine/threonine kinase 1 ; Homo sapiens







26 Article(s)
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Pub. Year
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1 35457111 The Inhibitory Response to PI3K/AKT Pathway Inhibitors MK-2206 and Buparlisib Is Related to Genetic Differences in Pancreatic Ductal Adenocarcinoma Cell Lines. 2022 Apr 13 1
2 33637776 BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression. 2021 Feb 26 2
3 33753551 AP-2α Regulates S-Phase and Is a Marker for Sensitivity to PI3K Inhibitor Buparlisib in Colon Cancer. 2021 Jul 1
4 34649154 Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation. 2021 Dec 1
5 32898555 Buparlisib modulates PD-L1 expression in head and neck squamous cell carcinoma cell lines. 2020 Nov 1 1
6 33371187 Proteomic Resistance Biomarkers for PI3K Inhibitor in Triple Negative Breast Cancer Patient-Derived Xenograft Models. 2020 Dec 21 1
7 30982255 [NVP-BKM120 in combination with letrozole inhibit human breast cancer stem cells via PI3K/mTOR pathway]. 2019 Apr 9 2
8 29430197 Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date. 2018 1
9 27507562 Combination of phosphotidylinositol-3-kinase targeting with cetuximab and irradiation: A preclinical study on an orthotopic xenograft model of head and neck cancer. 2017 Jan 1
10 28662162 BKM120 induces apoptosis and inhibits tumor growth in medulloblastoma. 2017 1
11 29024814 Anti-tumor effects of NVP-BKM120 alone or in combination with MEK162 in biliary tract cancer. 2017 Dec 28 1
12 29151909 BKM120 sensitizes C6 glioma cells to temozolomide via suppression of the PI3K/Akt/NF-κB/MGMT signaling pathway. 2017 Dec 2
13 27121230 Combined use of PI3K and MEK inhibitors synergistically inhibits lung cancer with EGFR and KRAS mutations. 2016 Jul 1
14 27307593 PI3K Pathway Inhibition Achieves Potent Antitumor Activity in Melanoma Brain Metastases In Vitro and In Vivo. 2016 Dec 1 2
15 27572309 Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells. 2016 Oct 11 1
16 25937299 Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cells. 2015 Aug 1 2
17 26044191 NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5. 2015 Aug 2
18 26256696 Comparative effect of two pan-class I PI3K inhibitors used as anticancer drugs on human T cell function. 2015 Sep 1
19 26402468 Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas. 2015 1
20 26673665 Effects of PI3K inhibitor NVP-BKM120 on overcoming drug resistance and eliminating cancer stem cells in human breast cancer cells. 2015 Dec 17 2
21 24310736 Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia. 2014 Jun 1
22 24741074 Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells. 2014 Jul 2
23 23238639 The phosphatidylinositol-3 kinase I inhibitor BKM120 induces cell death in B-chronic lymphocytic leukemia cells in vitro. 2013 Jul 1
24 23850807 The phosphatidylinositol-3-kinase inhibitor NVP-BKM120 overcomes resistance signals derived from microenvironment by regulating the Akt/FoxO3a/Bim axis in chronic lymphocytic leukemia cells. 2013 Nov 4
25 24337846 Effects of PI3K inhibitor NVP-BKM120 on acquired resistance to gefitinib of human lung adenocarcinoma H1975 cells. 2013 Dec 2
26 22159814 NVP-BKM120, a novel PI3K inhibitor, shows synergism with a STAT3 inhibitor in human gastric cancer cells harboring KRAS mutations. 2012 Apr 1