Sunitinib

AKT serine/threonine kinase 1 ; Homo sapiens







38 Article(s)
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1 35216667 Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma. 2022 Apr 7 1
2 35318312 Single-cell RNA-sequencing analysis reveals MYH9 promotes renal cell carcinoma development and sunitinib resistance via AKT signaling pathway. 2022 Mar 22 3
3 33893075 G-Protein-coupled Estrogen Receptor 1 Agonist G-1 Perturbs Sunitinib Resistance-related Phosphoproteomic Signatures in Renal Cell Carcinoma. 2021 May-Jun 1
4 34765076 Tissue based biomarkers in non-clear cell RCC: Correlative analysis from the ASPEN clinical trial. 2021 Oct 1
5 30281919 NT5E inhibition suppresses the growth of sunitinib-resistant cells and EMT course and AKT/GSK-3β signaling pathway in renal cell cancer. 2019 Jan 1
6 30821250 Synergic effects of inhibition of glycolysis and multikinase receptor signalling on proliferation and migration of endothelial cells. 2019 Mar 1
7 29435010 Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis. 2018 Mar 1
8 30369518 Interleukin-6 induces drug resistance in renal cell carcinoma. 2018 Dec 8 1
9 28327411 Gas6-Axl signaling in presence of Sunitinib is enhanced, diversified and sustained in renal tumor cells, resulting in tumor-progressive advantages. 2017 Jun 1 1
10 28898759 Cuprous oxide nanoparticles trigger ER stress-induced apoptosis by regulating copper trafficking and overcoming resistance to sunitinib therapy in renal cancer. 2017 Nov 1
11 28903416 Overriding TKI resistance of renal cell carcinoma by combination therapy with IL-6 receptor blockade. 2017 Aug 15 1
12 27016208 Schedule-dependent cytotoxicity of sunitinib and TRAIL in human non-small cell lung cancer cells with or without EGFR and KRAS mutations. 2016 Aug 1
13 27538132 [Sunitinib induces autophagy via suppressing Akt/mTOR pathway in renal cell carcinoma]. 2016 Feb 18 3
14 29263493 [Sunitinib induces autophagy via suppressing Akt/mTOR pathway in renal cell carcinoma]. 2016 Aug 18 3
15 25637219 AXL as a modulator of sunitinib response in glioblastoma cell lines. 2015 Mar 1 3
16 25917740 Enhanced Sensitivity to Sunitinib by Inhibition of Akt1 Expression in Human Castration-resistant Prostate Cancer PC3 Cells Both In Vitro and In Vivo. 2015 May 5
17 25993161 Biology and clinical management challenges in meningioma. 2015 1
18 26788996 Prevention of Venous Neointimal Hyperplasia by a Multitarget Receptor Tyrosine Kinase Inhibitor. 2015 1
19 24018642 Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer. 2014 Jan 1 1
20 24045439 Distinct pathways regulated by RET and estrogen receptor in luminal breast cancer demonstrate the biological basis for combination therapy. 2014 Apr 1
21 24974736 Platelets promote osteosarcoma cell growth through activation of the platelet-derived growth factor receptor-Akt signaling axis. 2014 Aug 1
22 25109654 Effect and mechanism of Src tyrosine kinase inhibitor sunitinib on the drug-resistance reversal of human A549/DDP cisplatin-resistant lung cancer cell line. 2014 Oct 1
23 25130811 [Effect of SU11248 on leukemia cell line K562 and its molecular mechanisms]. 2014 Aug 2
24 23812726 Survey of activated kinase proteins reveals potential targets for cholangiocarcinoma treatment. 2013 Dec 1
25 23969186 Antiproliferative and proapoptotic activity of sunitinib on endothelial and anaplastic thyroid cancer cells via inhibition of Akt and ERK1/2 phosphorylation and by down-regulation of cyclin-D1. 2013 Sep 3
26 21445973 Long-term exposure of gastrointestinal stromal tumor cells to sunitinib induces epigenetic silencing of the PTEN gene. 2012 Feb 15 1
27 21445974 Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway. 2012 Feb 15 4
28 22338018 New strategies for advanced neuroendocrine tumors in the era of targeted therapy. 2012 Apr 1 1
29 22532600 Modulation of Akt/mTOR signaling overcomes sunitinib resistance in renal and prostate cancer cells. 2012 Jul 1
30 22733151 Platelet-derived growth factor may be a potential diagnostic and prognostic marker for cholangiocarcinoma. 2012 Oct 2
31 23650573 IGF-1 receptor is down-regulated by sunitinib induces MDM2-dependent ubiquitination. 2012 1
32 21187670 Effect of sunitinib combined with ionizing radiation on endothelial cells. 2011 1
33 21344032 Sunitinib malate synergistically potentiates anti-tumor effect of gemcitabine in human bladder cancer cells. 2011 Jan 2
34 21693010 Sunitinib inhibits lymphatic endothelial cell functions and lymph node metastasis in a breast cancer model through inhibition of vascular endothelial growth factor receptor 3. 2011 Jun 21 1
35 20053726 Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways. 2010 Jan 3
36 19467916 FLT3 inhibition and mechanisms of drug resistance in mutant FLT3-positive AML. 2009 Jun 1
37 18514780 SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. 2008 Jul 1 1
38 16916320 Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling. 2006 Sep 3