Celecoxib

AKT serine/threonine kinase 1 ; Homo sapiens







76 Article(s)
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51 18226852 Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells. 2008 Apr 18 1
52 18296338 The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets. 2008 1
53 18343721 Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction. 2008 Apr 5
54 18413793 Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. 2008 Apr 1
55 17257745 Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway. 2007 Jun 28 2
56 17505004 Enhancement of docetaxel-induced cytotoxicity by blocking epidermal growth factor receptor and cyclooxygenase-2 pathways in squamous cell carcinoma of the head and neck. 2007 May 15 1
57 16455452 A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth. 2006 Feb 1
58 16731749 Motexafin gadolinium modulates levels of phosphorylated Akt and synergizes with inhibitors of Akt phosphorylation. 2006 May 1
59 17018636 Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells. 2006 Oct 1 3
60 15546138 Sulindac and its metabolites inhibit invasion of glioblastoma cells via down-regulation of Akt/PKB and MMP-2. 2005 Feb 15 1
61 15987447 Mechanisms underlying the growth inhibitory effects of the cyclo-oxygenase-2 inhibitor celecoxib in human breast cancer cells. 2005 1
62 16168126 Celecoxib analogues disrupt Akt signaling, which is commonly activated in primary breast tumours. 2005 5
63 16419156 Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis. 2005 Oct 28 1
64 14654083 Increased cyclooxygenase-2 (COX-2): a potential role in the pathogenesis of lymphoma. 2004 Feb 1
65 14961568 Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemoprevention. 2004 Apr 10 3
66 14973075 3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells. 2004 Feb 15 6
67 15026550 The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells. 2004 Mar 3
68 15205346 From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. 2004 Jun 15 2
69 15265936 Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. 2004 Aug 1 3
70 15634661 Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms. 2004 Dec 1
71 12939602 Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. 2003 Sep 2
72 11911965 Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib. 2002 Jun 6 1
73 12000750 Celecoxib induces apoptosis by inhibiting 3-phosphoinositide-dependent protein kinase-1 activity in the human colon cancer HT-29 cell line. 2002 Aug 2 3
74 12464646 Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. 2002 Dec 4 1
75 12499282 Insulin-like growth factor-I antagonizes the antiproliferative effects of cyclooxygenase-2 inhibitors on BxPC-3 pancreatic cancer cells. 2002 Dec 15 1
76 10753955 The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. 2000 Apr 14 5