Palmitic Acid

AKT serine/threonine kinase 1 ; Homo sapiens







47 Article(s)
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1 34619135 Chronic Exposure to Palmitic Acid Down-Regulates AKT in Beta-Cells through Activation of mTOR. 2022 Jan 4
2 34953312 Melatonin alleviates insulin resistance through the PI3K/AKT signaling pathway in ovary granulosa cells of polycystic ovary syndrome. 2022 Mar 2
3 35405148 Meroterpenoids containing benzopyran or benzofuran motif from Ganoderma cochlear. 2022 Jul 3
4 35585811 Docosahexaenoic acid ester of phloridzin reduces inflammation and insulin resistance via AMPK. 2022 May 18 1
5 33562475 The Increased Expression of Regulator of G-Protein Signaling 2 (RGS2) Inhibits Insulin-Induced Akt Phosphorylation and Is Associated with Uncontrolled Glycemia in Patients with Type 2 Diabetes. 2021 Feb 5 2
6 33686181 Palmitic acid promotes resistin-induced insulin resistance and inflammation in SH-SY5Y human neuroblastoma. 2021 Mar 8 1
7 34097902 Effect of trivalent chromium on erythropoietin production and the prevention of insulin resistance in HepG2 cells. 2021 Sep 15 2
8 34308859 [Exendin-4 promotes autophagy to relieve lipid deposition in a NAFLD cell model by activating AKT/mTOR signaling pathway]. 2021 Jul 20 2
9 34332276 Activation of κ-opioid receptor inhibits inflammatory response induced by sodium palmitate in human umbilical vein endothelial cells. 2021 Oct 2
10 34503515 TRIB3 regulates FSHR expression in human granulosa cells under high levels of free fatty acids. 2021 Sep 9 1
11 34653428 Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway. 2021 Dec 1 3
12 31518729 Mechanism of palmitic acid-induced deterioration of in vitro development of porcine oocytes and granulosa cells. 2020 Jan 1 2
13 33330513 C-Peptide Inhibits Decidualization in Human Endometrial Stromal Cells via GSK3β-PP1. 2020 1
14 30678035 Ganoderma lucidum Polysaccharides Prevent Palmitic Acid-Evoked Apoptosis and Autophagy in Intestinal Porcine Epithelial Cell Line via Restoration of Mitochondrial Function and Regulation of MAPK and AMPK/Akt/mTOR Signaling Pathway. 2019 Jan 23 2
15 30764838 κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway. 2019 Feb 14 2
16 30799086 Nucleophosmin/B23 contributes to hepatic insulin resistance through the modulation of NF-κB pathway. 2019 Apr 2 1
17 30913535 Palmitic acid causes insulin resistance in granulosa cells via activation of JNK. 2019 May 3
18 31223033 Pterostilbene reverses palmitic acid mediated insulin resistance in HepG2 cells by reducing oxidative stress and triglyceride accumulation. 2019 Jul 1
19 31332162 Upregulation of SLAMF3 on human T cells is induced by palmitic acid through the STAT5-PI3K/Akt pathway and features the chronic inflammatory profiles of type 2 diabetes. 2019 Jul 22 3
20 31828133 Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway. 2019 3
21 31839747 PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell. 2019 2
22 29307883 Phlorizin Exerts Direct Protective Effects on Palmitic Acid (PA)-Induced Endothelial Dysfunction by Activating the PI3K/AKT/eNOS Signaling Pathway and Increasing the Levels of Nitric Oxide (NO). 2018 Jan 8 2
23 29607540 Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein. 2018 Sep 1
24 29720254 Concurrent interactome and metabolome analysis reveals role of AKT1 in central carbon metabolism. 2018 May 2 1
25 29768267 Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ. 2018 1
26 28011403 Cyanidin-3-O-glucoside ameliorates palmitate-induced insulin resistance by modulating IRS-1 phosphorylation and release of endothelial derived vasoactive factors. 2017 Mar 1
27 28656239 Erythropoietin ameliorates PA-induced insulin resistance through the IRS/AKT/FOXO1 and GSK-3β signaling pathway, and inhibits the inflammatory response in HepG2 cells. 2017 Aug 1
28 28659580 Palmitic Acid-BSA enhances Amyloid-β production through GPR40-mediated dual pathways in neuronal cells: Involvement of the Akt/mTOR/HIF-1α and Akt/NF-κB pathways. 2017 Jun 28 4
29 28827061 Disruption of the mitochondria-associated ER membrane (MAM) plays a central role in palmitic acid-induced insulin resistance. 2017 Oct 1 4
30 28919254 Palmitic acid stimulates energy metabolism and inhibits insulin/PI3K/AKT signaling in differentiated human neuroblastoma cells: The role of mTOR activation and mitochondrial ROS production. 2017 Nov 3
31 26475209 Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression. 2016 Jan 1
32 26748475 PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation. 2016 Feb 1
33 26899878 Comparative Proteomic Study of Fatty Acid-treated Myoblasts Reveals Role of Cox-2 in Palmitate-induced Insulin Resistance. 2016 Feb 22 1
34 27665476 Ghrelin protects against palmitic acid or lipopolysaccharide-induced hepatocyte apoptosis through inhibition of MAPKs/iNOS and restoration of Akt/eNOS pathways. 2016 Dec 1
35 25737480 Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis. 2015 Jul 3
36 25891779 Metformin attenuates palmitic acid-induced insulin resistance in L6 cells through the AMP-activated protein kinase/sterol regulatory element-binding protein-1c pathway. 2015 Jun 2
37 25938832 [Role of PI3K/Akt pathway in endoplasmic reticulum stress and apoptosis induced by saturated fatty acid in human steatotic hepatocytes]. 2015 Mar 2
38 26064210 SHIP2 on pI3K/Akt pathway in palmitic acid stimulated islet β cell. 2015 1
39 26643367 Erythropoietin alleviates hepatic insulin resistance via PPARγ-dependent AKT activation. 2015 Dec 8 2
40 24857031 Synergistic effect of natural compounds on the fatty acid-induced autophagy of activated hepatic stellate cells. 2014 Sep 1
41 24918290 Eicosapentaenoic acid protects against palmitic acid-induced endothelial dysfunction via activation of the AMPK/eNOS pathway. 2014 Jun 10 1
42 25079440 TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS. 2014 Jul 30 3
43 21620957 ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation. 2011 Jul 15 5
44 20079751 High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1. 2010 Mar 1
45 19336660 Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action. 2009 Jun 1
46 19494713 Disruption of glucose homeostasis and induction of insulin resistance by elevated free fatty acids in human L02 hepatocytes. 2009 May 1
47 19721393 Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. 2009 Sep 2