Nicotine

AKT serine/threonine kinase 1 ; Homo sapiens







63 Article(s)
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1 35085258 Nicotine treatment regulates PD-L1 and PD-L2 expression via inhibition of Akt pathway in HER2-type breast cancer cells. 2022 3
2 33276105 Choline and nicotine increase glioblastoma cell proliferation by binding and activating α7- and α9- containing nicotinic receptors. 2021 Jan 1
3 33786606 Molecular insights into the benefits of nicotine on memory and cognition (Review). 2021 Jun 2
4 33997178 VPS33B suppresses lung adenocarcinoma metastasis and chemoresistance to cisplatin. 2021 May 1
5 34009037 Understanding potential mechanisms of harm: the drivers of electronic cigarette-induced changes in alveolar macrophages, neutrophils, and lung epithelial cells. 2021 Aug 1 1
6 34171359 Nicotine stimulates CYP1A1 expression in human hepatocellular carcinoma cells via AP-1, NF-κB, and AhR. 2021 Oct 1 1
7 34230140 Effects of Epstein-Barr Virus Infection on the Response of Human Breast Cancer Cells to Nicotine. 2021 Jul 1
8 32106059 Human secreted protein SLURP-1 abolishes nicotine-induced proliferation, PTEN down-regulation and α7-nAChR expression up-regulation in lung cancer cells. 2020 Feb 24 1
9 32361056 An okadaic acid fragment analogue prevents nicotine-induced resistance to cisplatin by recovering PP2A activity in non-small cell lung cancer cells. 2020 Jul 3
10 32767216 Nicotine Alleviates Cortical Neuronal Injury by Suppressing Neuroinflammation and Upregulating Neuronal PI3K-AKT Signaling in an Eclampsia-Like Seizure Model. 2020 Oct 3
11 32976884 Inflection of Akt/mTOR/STAT-3 cascade in TNF-α induced protein 8 mediated human lung carcinogenesis. 2020 Dec 1 1
12 33927788 Machine Learning Neuroprotective Strategy Reveals a Unique Set of Parkinson Therapeutic Nicotine Analogs. 2020 3
13 30345917 Astrocytic α7 Nicotinic Receptor Activation Inhibits Amyloid-β Aggregation by Upregulating Endogenous αB-crystallin through the PI3K/Akt Signaling Pathway. 2019 1
14 30836163 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. 2019 May 1 2
15 30944308 VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma. 2019 Apr 3 1
16 31123168 Nicotine promotes the development of non-small cell lung cancer through activating LINC00460 and PI3K/Akt signaling. 2019 Jun 28 1
17 28963785 Nicotine increases apoptosis in HUVECs cultured in high glucose/high fat via Akt ubiquitination and degradation. 2018 Feb 5
18 29215705 Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells. 2018 Jun 1
19 29396723 Duration-dependent effects of nicotine exposure on growth and AKT activation in human kidney epithelial cells. 2018 Nov 3
20 28252009 Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module. 2017 Mar 2 1
21 28385482 Nicotine promotes cervical carcinoma cell line HeLa migration and invasion by activating PI3k/Akt/NF-κB pathway in vitro. 2017 Jul 5 3
22 28474065 [Ginsenoside Rg1 regulates the proliferation and migration of human periodontal ligament cells via Akt/eNOS signaling under nicotine stress]. 2017 Feb 2
23 28957813 Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR. 2017 1
24 26530054 Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway. 2016 Jan 1
25 26548452 Anti-inflammatory and anti-osteoclastogenic effects of zinc finger protein A20 overexpression in human periodontal ligament cells. 2016 Aug 1
26 26870265 Nicotine enhances hepatocyte growth factor-mediated lung cancer cell migration by activating the α7 nicotine acetylcholine receptor and phosphoinositide kinase-3-dependent pathway. 2016 Jan 3
27 26909550 Nicotine Inhibits Cisplatin-Induced Apoptosis via Regulating α5-nAChR/AKT Signaling in Human Gastric Cancer Cells. 2016 2
28 27224911 Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation. 2016 Jun 21 1
29 27424921 Nicotine enhances the malignant potential of human pancreatic cancer cells via activation of atypical protein kinase C. 2016 Nov 1
30 25565665 HIF-2 Inhibition Supresses Inflammatory Responses and Osteoclastic Differentiation in Human Periodontal Ligament Cells. 2015 Jul 1
31 25670150 Nicotine induces resistance to erlotinib via cross-talk between α 1 nAChR and EGFR in the non-small cell lung cancer xenograft model. 2015 Apr 2
32 26184482 Nicotine Induces Tumor Growth and Chemoresistance through Activation of the PI3K/Akt/mTOR Pathway in Bladder Cancer. 2015 Sep 3
33 26351626 Ex vivo nicotine stimulation augments the efficacy of human peripheral blood mononuclear cell-derived dendritic cell vaccination via activating Akt-S6 pathway. 2015 4
34 26397133 Early and delayed intervention with rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice. 2015 Dec 1
35 24548862 Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability. 2014 Apr 2 1
36 22614999 Nicotine enhances proliferation, migration, and radioresistance of human malignant glioma cells through EGFR activation. 2013 Apr 2
37 23543412 Nicotine-induced structural plasticity in mesencephalic dopaminergic neurons is mediated by dopamine D3 receptors and Akt-mTORC1 signaling. 2013 Jun 1
38 24095863 Nicotine increases survival in human colon cancer cells treated with chemotherapeutic drugs. 2013 Dec 3
39 22188668 Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7. 2012 Feb 1
40 22248034 Neuroprotection by nicotine against colchicine-induced apoptosis is mediated by PI3-kinase--Akt pathways. 2012 Jun 3
41 22349311 Mitochondrial reactive oxygen species mediates nicotine-induced hypoxia-inducible factor-1α expression in human non-small cell lung cancer cells. 2012 Jun 1
42 22520577 Nicotine stimulates proliferation and inhibits apoptosis in colon cancer cell lines through activation of survival pathways. 2012 Nov 2
43 22085699 Sensitization of epithelial growth factor receptors by nicotine exposure to promote breast cancer cell growth. 2011 1
44 20338106 Nicotine induces resistance to chemotherapy in nasal epithelial cancer. 2010 Mar-Apr 3
45 20685820 Nicotine worsens the severity of nephropathy in diabetic mice: implications for the progression of kidney disease in smokers. 2010 Oct 1
46 20727180 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. 2010 Aug 20 1
47 20851953 Curcumin inhibits carcinogen and nicotine-induced Mammalian target of rapamycin pathway activation in head and neck squamous cell carcinoma. 2010 Dec 2
48 18331557 Expression of phosphorylated Akt in oral carcinogenesis and its induction by nicotine and alkaline stimulation. 2009 Feb 7
49 19499400 Nicotine-reduced endothelial progenitor cell senescence through augmentation of telomerase activity via the PI3K/Akt pathway. 2009 3
50 17015027 Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells. 2007 3