2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone

NAD(P)H quinone dehydrogenase 1 ; Homo sapiens







11 Article(s)
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1 26424559 Implications of NQO1 in cancer therapy. 2015 Nov 1
2 21250978 The anti-tumour compound, RH1, causes mitochondria-mediated apoptosis by activating c-Jun N-terminal kinase. 2011 Jun 6
3 18794327 Dissecting the role of multiple reductases in bioactivation and cytotoxicity of the antitumor agent 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). 2008 Dec 2
4 17015278 The reductive activation of the antitumor drug RH1 to its semiquinone free radical by NADPH cytochrome P450 reductase and by HCT116 human colon cancer cells. 2006 Sep 4
5 15746574 Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction. 2005 Apr 2
6 15131056 Development of a new isogenic cell-xenograft system for evaluation of NAD(P)H:quinone oxidoreductase-directed antitumor quinones: evaluation of the activity of RH1. 2004 May 1 2
7 15554240 Quinone reductases multitasking in the metabolic world. 2004 Oct 2
8 14666706 Activity profile of the novel aziridinylbenzoquinones MeDZQ and RH1 in human tumour xenografts. 2003 Sep-Oct 1
9 11248489 Stability-indicating HPLC assay and solution stability of a new diaziridinyl benzoquinone. 2001 Mar 1
10 10718341 Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice. 2000 Apr 1 2
11 9865924 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. 1998 Dec 4