Citric Acid

ATP citrate lyase ; Homo sapiens







54 Article(s)
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1 35264789 A non-canonical tricarboxylic acid cycle underlies cellular identity. 2022 Mar 1
2 35402505 A Nutrient-Based Cellular Model to Characterize Acetylation-Dependent Protein-Protein Interactions. 2022 2
3 35404187 Selective autophagic degradation of ACLY (ATP citrate lyase) maintains citrate homeostasis and promotes oocyte maturation. 2022 Apr 25 5
4 32448086 Discovery of a new ATP-citrate lyase (ACLY) inhibitor identified by a pharmacophore-based virtual screening study. 2021 Jul 2
5 34122722 Phenolic Compounds of Red Wine Aglianico del Vulture Modulate the Functional Activity of Macrophages via Inhibition of NF-κB and the Citrate Pathway. 2021 5
6 34323067 Regulation on Citrate Influx and Metabolism through Inhibiting SLC13A5 and ACLY: A Novel Mechanism Mediating the Therapeutic Effects of Curcumin on NAFLD. 2021 Aug 11 4
7 34831186 ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation. 2021 Oct 30 2
8 31499095 ATP-citrate lyase (ACLY) in lipid metabolism and atherosclerosis: An updated review. 2020 Jan 1
9 31873304 Molecular basis for acetyl-CoA production by ATP-citrate lyase. 2020 Jan 1
10 31947614 The Drosophila Citrate Lyase Is Required for Cell Division during Spermatogenesis. 2020 Jan 14 2
11 32164290 Comparative Metabolites and Citrate-Degrading Enzymes Activities in Citrus Fruits Reveal the Role of Balance between ACL and Cyt-ACO in Metabolite Conversions. 2020 Mar 10 4
12 32692565 Cell Metabolomics Reveals Berberine-Inhibited Pancreatic Cancer Cell Viability and Metastasis by Regulating Citrate Metabolism. 2020 Sep 4 1
13 32849657 Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. 2020 1
14 33096779 Liposome-Mediated Inhibition of Inflammation by Hydroxycitrate. 2020 Oct 21 2
15 33282912 Extracellular Citrate Is a Trojan Horse for Cancer Cells. 2020 1
16 29745322 Metabolic Routes in Inflammation: The Citrate Pathway and its Potential as Therapeutic Target. 2019 5
17 30586346 Bempedoic acid: effects on lipoprotein metabolism and atherosclerosis. 2019 Feb 1
18 30944472 An allosteric mechanism for potent inhibition of human ATP-citrate lyase. 2019 Apr 1
19 30944476 Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. 2019 Apr 1
20 31019471 Depletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells. 2019 2
21 31150280 ATP-citrate lyase is an epigenetic regulator to promote obesity-related kidney injury. 2019 Aug 1
22 31411782 Identification of the active site residues in ATP-citrate lyase's carboxy-terminal portion. 2019 Oct 1
23 29929979 Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. 2018 Aug 3 1
24 30050389 New Insights into Behçet's Syndrome Metabolic Reprogramming: Citrate Pathway Dysregulation. 2018 5
25 30195238 ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism. 2018 Sep 5 2
26 28059952 ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia. 2017 Apr 1
27 28167750 ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection. 2017 Feb 21 1
28 27912843 The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target. 2016 Nov 1
29 25367309 ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway. 2015 Jan 1
30 25511512 Targeting mitochondrial citrate transport in breast cancer cell lines. 2015 1
31 25537655 ATP citrate lyase (ACLY): a promising target for cancer prevention and treatment. 2015 1
32 25619261 Citrate modulates lipopolysaccharide-induced monocyte inflammatory responses. 2015 Jun 2
33 25701462 Decreased Warburg effect induced by ATP citrate lyase suppression inhibits tumor growth in pancreatic cancer. 2015 Mar 1
34 26039450 ATP citrate lyase improves mitochondrial function in skeletal muscle. 2015 Jun 2 1
35 25277207 Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity. 2014 Sep 15 1
36 21688263 Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. 2012 Apr 1
37 22510345 Changes in gene transcription underlying the aberrant citrate and choline metabolism in human prostate cancer samples. 2012 Jun 15 2
38 22575446 ATP-citrate lyase: a mini-review. 2012 May 25 1
39 22657152 On the catalytic mechanism of human ATP citrate lyase. 2012 Jun 26 1
40 22787121 ATP-citrate lyase: a key player in cancer metabolism. 2012 Aug 1 1
41 19795461 Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas. 2010 May 15 2
42 20558738 Identification of the citrate-binding site of human ATP-citrate lyase using X-ray crystallography. 2010 Aug 27 2
43 21170889 Low urinary citrate: an overview. 2010 Nov-Dec 1
44 19286649 A novel direct homogeneous assay for ATP citrate lyase. 2009 Oct 2
45 15733107 Effects of potassium-magnesium citrate supplementation on cytosolic ATP citrate lyase and mitochondrial aconitase activity in leukocytes: a window on renal citrate metabolism. 2005 Feb 4
46 16007201 ATP citrate lyase is an important component of cell growth and transformation. 2005 Sep 15 2
47 16226706 ATP citrate lyase inhibition can suppress tumor cell growth. 2005 Oct 1
48 12079877 A novel Mammalian homologue of a bacterial citrate-metabolizing enzyme. 2002 Jun 1
49 12367768 Urinary citrate excretion in patients with renal stone: roles of leucocyte ATP citrate lyase activity and potassium salts therapy. 2002 Nov 1
50 1479587 ATP-citrate lyase as a target for hypolipidemic intervention. Sulfoximine and 3-hydroxy-beta-lactam containing analogues of citric acid as potential tight-binding inhibitors. 1992 Dec 25 1