acadesine

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ; Homo sapiens







50 Article(s)
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1 33228044 Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies. 2020 Nov 19 1
2 31431503 The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion. 2019 Oct 18 1
3 29773845 AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages. 2018 May 17 1
4 30107094 Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer. 2018 Nov 1
5 27847321 AICAR activates ER stress-dependent apoptosis in gallbladder cancer cells. 2017 Jan 8 2
6 28407446 Doping control study of AICAR in post-race urine and plasma samples from horses. 2017 Sep 2
7 28719670 Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells. 2017 1
8 29032594 Implementation of AICAR analysis by GC-C-IRMS for anti-doping purposes. 2017 Nov 1
9 29247196 AICAR suppresses TNF-α-induced complement factor B in RPE cells. 2017 Dec 15 1
10 26446934 New synthetic AICAR derivatives with enhanced AMPK and ACC activation. 2016 Oct 1
11 27103440 AICAR induces AMPK-independent programmed necrosis in prostate cancer cells. 2016 May 27 2
12 27170207 AICAR Attenuates TNFα-Induced Inappropriate Secretion of Monocyte Chemoattractant Protein-1 and Adiponectin in 3T3-L1 Adipocytes. 2016 Dec 1 1
13 27521792 Adenosine monophosphate-activated protein kinase attenuates cardiomyocyte hypertrophy through regulation of FOXO3a/MAFbx signaling pathway. 2016 Sep 1
14 27562249 AMPK-independent inhibition of human macrophage ER stress response by AICAR. 2016 Aug 26 1
15 26109067 Wnt/β-Catenin Mediates AICAR Effect to Increase GATA3 Expression and Inhibit Adipogenesis. 2015 Aug 7 1
16 26286955 Exercise-mimetic AICAR transiently benefits brain function. 2015 Jul 30 1
17 24760559 Determination of ¹³C/¹² C ratios of endogenous urinary 5-amino-imidazole-4-carboxamide 1β-D-ribofuranoside (AICAR). 2014 Jun 15 2
18 24778186 Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters. 2014 Jun 13 2
19 24915467 Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D. 2014 Jul 1
20 23018889 Involvement of Akt2/protein kinase B β (PKBβ) in the 8-Cl-cAMP-induced cancer cell growth inhibition. 2013 Apr 1
21 23076989 Functional analysis of missense mutations of OAT, causing gyrate atrophy of choroid and retina. 2013 Jan 1
22 23531513 AICAR inhibits PPARγ during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids. 2013 Jun 1 1
23 21956774 Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells. 2012 Jan 1
24 22231556 AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. 2012 Jan 8 1
25 22554803 Augmentation of reduced folate carrier-mediated folate/antifolate transport through an antiport mechanism with 5-aminoimidazole-4-carboxamide riboside monophosphate. 2012 Aug 1
26 21479175 An invertebrate hyperglycemic model for the identification of anti-diabetic drugs. 2011 Mar 30 1
27 21795305 The influence of the BRAF V600E mutation in thyroid cancer cell lines on the anticancer effects of 5-aminoimidazole-4-carboxamide-ribonucleoside. 2011 Oct 1
28 21918180 Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology. 2011 Dec 1
29 21945951 The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases. 2011 Nov-Dec 1
30 20615388 AICAR induces cyclooxygenase-2 expression through AMP-activated protein kinase-transforming growth factor-beta-activated kinase 1-p38 mitogen-activated protein kinase signaling pathway. 2010 Oct 15 1
31 20664053 AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. 2010 Oct 21 1
32 18473182 Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). 2009 Jun 2
33 19144636 AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D. 2009 Mar 6 1
34 19190259 Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status. 2009 May 1
35 17945190 AICAR positively regulate glycogen synthase activity and LDL receptor expression through Raf-1/MEK/p42/44MAPK/p90RSK/GSK-3 signaling cascade. 2008 Jan 15 1
36 18063805 AMP-activated protein kinase phosphorylates transcription factors of the CREB family. 2008 Feb 2
37 18199594 Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. 2008 Mar 1
38 18326758 Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells. 2008 Mar 1
39 18801732 AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3beta and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. 2008 Dec 5 1
40 18031613 AICAR inhibits proliferation and induced S-phase arrest, and promotes apoptosis in CaSki cells. 2007 Dec 1
41 15860681 AICAR and hyperosmotic stress increase insulin-stimulated glucose transport. 2005 Sep 1
42 15910743 AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells. 2005 Jul 1 1
43 15033479 AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. 2004 Apr 9 1
44 15328001 Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. 2004 Aug 27 1
45 15358229 AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. 2004 Aug 13 1
46 12791703 Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. 2003 Aug 22 1
47 11509501 Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. 2001 Sep 1
48 11554766 Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. 2001 Sep 21 1
49 11016448 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. 2000 Oct 2
50 2006182 Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. 1991 Mar 15 1