Phosphatidylcholines

ATP binding cassette subfamily B member 4 ; Homo sapiens







70 Article(s)
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Pub. Year
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1 35203270 MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression. 2022 Feb 10 1
2 33672718 Molecular Regulation of Canalicular ABC Transporters. 2021 Feb 20 1
3 34022183 Monomeric bile acids modulate the ATPase activity of detergent-solubilized ABCB4/MDR3. 2021 6
4 34107287 Evidence for a credit-card-swipe mechanism in the human PC floppase ABCB4. 2021 Oct 7 2
5 34209301 RAB10 Interacts with ABCB4 and Regulates Its Intracellular Traffic. 2021 Jun 30 4
6 34385322 Structures of ABCB4 provide insight into phosphatidylcholine translocation. 2021 Aug 17 4
7 31873305 Structure of the human lipid exporter ABCB4 in a lipid environment. 2020 Jan 1
8 32917728 Stimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid. 2020 Dec 6
9 33256620 Case report: progressive familial intrahepatic cholestasis type 3 with compound heterozygous ABCB4 variants diagnosed 15 years after liver transplantation. 2020 Nov 30 2
10 33383947 Gene Therapy for Progressive Familial Intrahepatic Cholestasis: Current Progress and Future Prospects. 2020 Dec 29 1
11 30222019 Paucity of Interlobular Bile Ducts in Multidrug-Resistant P-Glycoprotein 3 (MDR3) Deficiency. 2019 May 1
12 30730833 ABCB4/MDR3 in health and disease - at the crossroads of biochemistry and medicine. 2019 Sep 25 3
13 31040306 Structural analogues of roscovitine rescue the intracellular traffic and the function of ER-retained ABCB4 variants in cell models. 2019 Apr 30 1
14 31176036 Enhancing effect of taurohyodeoxycholate on ABCB4-mediated phospholipid efflux. 2019 Oct 4
15 31538486 Familial low phospholipid-associated cholelithiasis resulting from an autosomal dominant ABCB4 mutation. 2019 Oct 1
16 31886153 Expression Analysis of ATP-Binding Cassette Transporters ABCB11 and ABCB4 in Primary Sclerosing Cholangitis and Variety of Pediatric and Adult Cholestatic and Noncholestatic Liver Diseases. 2019 1
17 29635711 Genetics of gallstone disease. 2018 Jul 1
18 30357767 ABCB4 Gene Aberrations in Human Liver Disease: An Evolving Spectrum. 2018 Nov 2
19 28012258 Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770). 2017 Feb 4
20 28127842 Hepatocarcinogenesis in multidrug-resistant P-glycoprotein 3 deficiency. 2017 May 1
21 28220208 ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population. 2017 Jul 1
22 26153658 Heterozygous ABCB4 mutations in children with cholestatic liver disease. 2016 Feb 3
23 26789121 A PDZ-Like Motif in the Biliary Transporter ABCB4 Interacts with the Scaffold Protein EBP50 and Regulates ABCB4 Cell Surface Expression. 2016 2
24 26900700 Functional Rescue of Trafficking-Impaired ABCB4 Mutants by Chemical Chaperones. 2016 3
25 27112167 Role of Multidrug Resistance Protein 3 in Antifungal-Induced Cholestasis. 2016 Jul 1
26 27256251 Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3. 2016 Jun 3 4
27 24594635 Functional analysis of ABCB4 mutations relates clinical outcomes of progressive familial intrahepatic cholestasis type 3 to the degree of MDR3 floppase activity. 2015 Jan 3
28 24620780 Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism. 2015 Mar 2
29 25173835 Expression of indocyanine green-related transporters in hepatocellular carcinoma. 2015 Feb 1
30 25533467 A mutation within the extended X loop abolished substrate-induced ATPase activity of the human liver ATP-binding cassette (ABC) transporter MDR3. 2015 Feb 20 1
31 25601960 ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner. 2015 Mar 4
32 26256905 Reversal of advanced fibrosis after long-term ursodeoxycholic acid therapy in a patient with residual expression of MDR3. 2015 Sep-Oct 3
33 24045840 Two ABCB4 point mutations of strategic NBD-motifs do not prevent protein targeting to the plasma membrane but promote MDR3 dysfunction. 2014 May 2
34 24122873 Peroxisome proliferator-activated receptor α activates human multidrug resistance transporter 3/ATP-binding cassette protein subfamily B4 transcription and increases rat biliary phosphatidylcholine secretion. 2014 Mar 4
35 24723470 Phosphorylation of ABCB4 impacts its function: insights from disease-causing mutations. 2014 Aug 4
36 24806754 Molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4. 2014 May 1
37 24953525 ABCB4: Insights from pathobiology into therapy. 2014 Oct 4
38 25133187 Molecular mechanisms for biliary phospholipid and drug efflux mediated by ABCB4 and bile salts. 2014 1
39 25544413 LPAC syndrome associated with deletion of the full exon 4 in a ABCB4 genetic mutation in a patient with hepatitis C. 2014 Dec 2
40 23305784 ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1. 2013 Apr 2
41 23468132 Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes. 2013 May 4
42 23593265 Detergent screening and purification of the human liver ABC transporters BSEP (ABCB11) and MDR3 (ABCB4) expressed in the yeast Pichia pastoris. 2013 3
43 22859919 Hepatobiliary transport in health and disease. 2012 Apr 1
44 23141892 Low phospholipid-associated cholestasis and cholelithiasis. 2012 Sep 3
45 21638239 Cholestatic liver diseases from child to adult: the diversity of MDR3 disease. 2011 Jun 2
46 21801087 Targeting the ABCB4 gene to control cholesterol homeostasis. 2011 Oct 4
47 20153493 Canine ABCB4: Tissue expression and cDNA structure. 2010 Aug 1
48 20422497 Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy. 2010 May 3
49 19018976 ABCB4 sequence variations in young adults with cholesterol gallstone disease. 2009 May 1
50 19185004 A missense mutation in ABCB4 gene involved in progressive familial intrahepatic cholestasis type 3 leads to a folding defect that can be rescued by low temperature. 2009 Apr 3